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Biomedical subjects

H Ochs

Publications and source records attributed to H Ochs.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Idiopathic thrombosis of the superior vena cava (author's transl)].

In contrast to secondary occlusion idiopathic thrombosis of the superior vena cava occurs rarely. With a good collateral flow through anatomically preformed venous channels the clinical picture may have an insidious course obscuring diagnosis. Collateral circulation via upper oesophageal varices is commonly overlooked. Anticoagulants should be given to prevent progression. Surgically vein transplants, by-pass operations, and thrombectomy have been tried. Follow-up in 4 patients shows that even without surgical intervention the prognosis is good despite the danger of haemorrhage from the varices.

Adult↗
PubMed1975

Absorption of digoxin from the distal parts of the intestine in man.

In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patients with normal colonic mucosa demonstrated extensive absorption in the distal part of the bowel. The results have been contrasted with the findings in 4 patients with ulcerative colitis who excreted only 1.66 +/- 0.6% of the given dose in 24 hours.

Adolescent↗
PubMed1975

[Biological availability of diagoxin in patients with or without gastric resection (Billroth II) (author's transl)].

Biological availability of digoxin tablets was measured during maintenance therapy in ten hospitalized patients who had had a Billroth II gastric resection at least two years previously. Twelve patients on digoxin maintenance for heart failure but without gastro-intestinal disease served as controls. The mean value of daily digoxin urinary excretion over ten days in the resection group was 38.09 +/- 0.70% of the administered dose. The serum-digitalis level 12 and 24 hours after the last dose of glycoside (0.5 mg) was 1.30 +/- 0.04 ng/ml and did not significantly differ from that of the control group, nor did digoxin elimination in urine and the digoxin/creatinin excretion ratio. It is concluded that two-third gastric resection with exclusion of antigrade duodenal passage does not influence biological availability of digoxin given in tablets.

Adult↗
PubMed1975

[Intravenous injection of thermometer mercury (author's transl)].

The possible complications in two women who had injected themselves intravenously with thermometer mercury with suicidal intent are discussed with reference to the few comparable cases. A manifest pulmonary hypertension due to multiple mercury emboli in the lesser circulation in one patient who developed a dyspnoea on exertion could be excluded by cardiac catheterization. Signs of acute and chronic mercury poisoning could not be demonstrated in our patients, in contrast to some cases reported in the literature. So far, specific therapy has therefore been dispensed with.

Adult↗
PubMed1975

[Comparison of digitoxin bioavailability from tablets and elixir during maintenance therapy (author's transl)].

The bioavalability of digoxin tablets and solution has been studied during maintenance therapy in a cross over study. Each preparation was given over a period of at least 7 days to patients with compensated congestive heart failure. Urine concentrations and plasma levels were analysed for digitoxin. There was no significant difference between the two preparations. Determination of steady state serum concentrations and urinary excretion during maintenance therapy as an index of bioavalability are more cumbersome than a single dose study. From a pharmacokinetic point of view however, analyses of steady-state conditions are preferable to a single dose study. In addition, steady state of drug input and output resembles the usual digitalis therapy.

Administration, Oral↗
PubMed1975

[Coronary fistula into the sinus coronarius. Hemodynamics, clinical aspects, therapy].

Coronary artery fistulas are rare, inborn anomalies which will be diagnosed more often as the diagnostic method of coronary arteriography is increasing. This report concerns a preoperatively diagnosed coronary arteriovenous fistula of the right coronary artery to the sinus coronarius; Frequency, pathological physiology, clinical symptoms, differential diagnosis, prognosis and treatment are discussed. The importance of using selective coronary arteriography to outline the anatomy of these malformations is stressed. Surgical treatment is the only effective way of therapy and should be performed after diagnosis, even if in an early stage of the disease the ECG does not show any changes in spite of a large fistula.

Adult↗
PubMed1975

[The Bland-White-Garland syndrome: hemodynamics, clinical picture, therapy].

Two patients with anomalous origin of the left coronary artery from the pulmonary artery are presented. Anatomy, embryology, the problem of the direction of blood flow in the anomalous vessel, and the clinical symptoms of this syndrome are discussed. In spite of large fibrotic areas in the myocardium, the ECG-changes were minimal. Therefore, a nearly normal ECG does not exclude this anomaly. In patients with sudden, unexpected death one should suspect an anomalous origin of a coronary artery. The classification in an "infantile" and "adult" type reflects the extent to which collateral vessels have developed. Ligation of the anomalous coronary artery at the side of its origin with concomitant aorto-coronary bypass appears to be a rational and the only effective way of therapy.

Adult↗