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Biomedical subjects

H Nogaki

Publications and source records attributed to H Nogaki.

At least 73 records · Page 4Linked to original sources
PubMed1983

[5-FU concentration in brain tumors after co-administration of FT and uracil].

Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay. Time course of FT in serum rapidly attenuated, but 5-FU was kept almost constant below 0.014 micrograms/ml. T/B ratio (5-FU in tumor/5-FU in blood) in 11 samples of meningioma was 6.86 +/- 3.67, while in 8 samples obtained from glioblastoma was significantly higher (23.79 +/- 11.43, p less than 0.001). In malignant brain tumors there was a correlation between the concentration of 5-FU and Uracil in tumor (gamma = 0.67). This correlation was more enhanced when the value of Uracil in tumor was over 15 micrograms/g (gamma = 0.81). The concentration of 5-FU in cyst was low, but tended to accumulated later. This result may be based on the diffusion of 5-FU from the surrounding solid part of tumor into the cyst. Our present study demonstrated that enhancing effect of 5-FU in brain tumors, particularly solid malignant glioma, was yielded after oral administration of UFT.

Brain Neoplasms↗
PubMed1983

[Nonsurgical technique for removal of catheter fragments in the heart and the great vessels].

With the widespread use of intravenous polyethylene or silicone elastomer catheters for continuous infusion of fluids and drugs and monitoring central venous pressure, loss of catheter fragments into the central circulation has become an increasing problem. These catheter fragments have been removed from all areas of the right side circulatory system by various techniques not requiring thoracotomy. Many kinds of instruments for nonsurgical removal of these fragments have been utilized. The majority of them have been accomplished using a loop snare or a helical basket. As with loop snares and baskets, a free end of fragments is necessary for fragment entrapment. In this report the authors describe four cases with catheter fragments in the heart or the great vessels and a new nonsurgical technique using a "forceps with three or two grasping prongs for endoscope" for their removal. In the first case, we could remove the embolized catheter fragment without accessible free ends in the pulmonary artery by this method. This special forceps with two grasping prongs was applicable even for the infant and could be inserted through a No. 8 French Cordis catheter introducer. This method is extremely promising for removal of catheter fragments in the central circulatory system.

Adult↗
PubMed1982

[Concentration of sulbenicillin in human serum and myocardial tissue].

The concentration of sulbenicillin in the serum and myocardial tissue of 13 patients were determined at cardiac surgery. About 100 mg/kg of sulbenicillin were administered intravenously for 60 minutes. Right auricle resected at the vena caval cannuration was examined for myocardial tissue. The serum concentration was also examined every 30 minutes after injection, 30 minutes, 60 minutes, 90 minutes, 120 minutes and 150 minutes. Mean values of serum concentration were 213.6 micrograms/ml, 432.5 micrograms/ml, 181.6 micrograms/ml, 236.3 micrograms/ml and 101 micrograms/ml, respectively. The values determined in myocardial tissue were 146.5 micrograms/g (60 minutes), 39.2 micrograms/g (90 minutes), 66.0 micrograms/g (120 minutes) and 23.5 micrograms/g (150 minutes). The mean value of concentration ratio of sulbenicillin in myocardial tissue was 0.23 of serum concentration. The high myocardial tissue levels of sulbenicillin suggests that its use at cardiovascular surgery would protect the myocardial tissue from the bacterial infections.

Adolescent↗