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Biomedical subjects

H Noack

Publications and source records attributed to H Noack.

At least 55 records · Page 3Linked to original sources
PubMed1989

The role of mitochondrial glutathione in the defence against Fe2+/ascorbate induced peroxidation of rat liver mitochondria.

The protective role of the glutathione system against oxidative stress was studied in the model of Fe2+/ascorbate induced peroxidation in isolated rat liver mitochondria. There was a successive diminution of the mitochondrial glutathione pool, essentially due to losses of the reduced form (GSH) during the initiation phase of peroxidation, while the redox state of glutathione was not influenced significantly before the onset of massive malondialdehyde formation. Oxidizable substrates such as glutamate/malate and 3-hydroxybutyrate affected peroxidation by extending the period of the induction phase. Obviously that was due to the supply of NADPH to recover GSH via GSSG-reductase as evidenced by the parallel decline of the NADP(H) and the glutathione-system redox states. Although the data strongly support the fact that mitochondrial glutathione plays a central role in the defence against oxidative stress, there are, under special conditions of a high succinate supply, other potent defence systems in isolated mitochondria.

Animals↗
PubMed1987

[The Berne Härz-As (Ace of Hearts) Project: goals, study plan and initial results].

The Berne Härz-As (Ace of Heart) project is a randomized trial in changing cardiovascular risk factors, morbidity and subjective health. It further investigates to what extent psychosocial and somatic factors account for these health indicators in the course of at least 4 years. A pilot study conducted in two companies (N = 620) indicates that the project is feasible and acceptable to both management and employees and that the intervention goals are justified.

Cardiovascular Diseases↗
PubMed1981

[Development and perspectives in general medicine].

Based on analyses of basic or preliminary care in Australia, Europe and North America and on empirical investigations the following conclusions are drawn: medical attention in primary care shows some special features (described in greater detail) and differs from medical attention in specialized treatment areas. The profession and the aims of postgraduate education of general medicine are based on these particulars, but they need further explanation and better delineation. Training and postgraduate training of general practitioners in most countries are only likely to achieve the aims set to a limited extent. It is assumed that the further development of general medicine depends especially on the improvement of the preliminary treatment system and research into preliminary care and on the training of qualified teachers.

Education, Medical, Continuing↗
PubMed1981

[Value of complex methods of evaluating microclimatic conditions].

The authors have checked the correctness and accuracy of the total index of microclimate evaluation, using an analog calculator to process the measurements. Information on the measurements of climate was analysed basing on the total index of climate evaluation qtr, Predicted -- 4 -- Hour -- Sweat -- Rate P4SR, Index of Thermal Stress ITS, Wet Bulb Globe Temperature WBGT, Globe -- Temperature tg, Heat Stress Index HSI, Humid Operative Temperature toH and Effective Temperature ET. In addition, under standard conditions, with differentiated degree of physical effort, the following physiological parameters have been determined in 37 subjects: heart rate, internal body temperature, skin temperature and sweat loss. The obtained data have undergone regression and correlation analysis, stating, among others, that the index of climate evaluation qtr and P4SR -- Index correlate best with all physiological parameters.

Body Temperature↗
PubMed1979

[Experimental findings after application of Kveim antigen. II. Sensibilization of mice and guinea pigs by Mycobacterium avium (serotype I) (author's transl)].

Mice and guinea pigs were sensibilisized by intraperitoneal injection of Mycobacterium avium (serotype I). Three and five weeks later (guinea pigs) and four weeks later (mice) the animals received kveim antigen into the footpads (guinea pigs) and into the perianal fat tissue (mice). Three and five weeks later (guinea pigs) and four weeks later (mice) the exstirpated material was investigated by light microscopy and enzyme histochemistry. Guinea pigs showed three and five weeks after injection of kveim antigen a lot of questionable positive and positive kveim tests and mice a high percentage of granulomatous changes, resembling a positive kveim reaction. With histochemical methods leucinaminopeptidase is a valuable diagnostic aid for detection of granulomatous changes in mice but not so good in guinea pigs.

Acid Phosphatase↗
PubMed1977

[Problems of hospital-delivery with the presence of the husband (author's transl)].

The authors have interviewed 740 women and their husbands after delivery about their attitude towards the presence of the husband at the time of delivery. Besides of traditional prejudices local circumstances in a hospital and shortage of staff make it difficult for the husband to attend to the delivery-room. Every woman would need in this case a room of her own for delivery; the number of midwifes or nurses would require a considerable increase. One problem might arise if the husband gets suspicious about certain events or actions during delivery and suspects malpractice; this might create new cases in court against the doctor. On the other hand it can be expected that prejudices and suspicions are decreased by the simple fact that the delivery room is opened to the husband. Most of the couples who were questioned replied positively; the results are summarized in tables. If the husband is allowed to attend to the delivery, it will become easier and more human. This point appears to be very important, as the hospital-delivery turns into a mere technical and impersonal service. If the husband can be present some "idyllic" aspects of the previous home-delivery are called back. Practical hints are given how the problem can be mastered.

Delivery, Obstetric↗
PubMed1977

[Puerperal mastitis].

The puerperal mastitis is a staphylococcal infection of the lactating mamma cumulating during the third and fourth week after delivery. It is seen three times as often after hospital than after house delivery, and it is also more frequent with primiparae than with multiparae. The infection is caused by bacterial hospitalism. Most commonly mamilla and milkducts are infected via the child's nasopharynx. Mastitis rarely occurs in non-nursing women. Early diagnosis before the appearance of all classical inflammatory symptoms is important, to start the treatment with antibiotics before abscess formation takes place. We mentioned Fucidine, Oleandomycin and Oxacillin as staphylococcal-effective, penicillinase-resistent antibiotics. Additionally low-dose X-ray radiation may be given. In case of abscess formation local antibiotic-instillation combined with oral antibiotic treatment should be tried before incision. It is best to incise an abscess only after is complete breakdown. Complications to be looked for are maternal sepsis and staphylococcal infection of the newborn.

Adult↗
PubMed1977

Programmed texts: success or failure? An analysis of medical students' opinions.

It is shown that German medical textbooks have sold about nine times better than programmed texts, even if they were written by the same author and on the same subject. To explore some of the reasons why programmed texts are being used so little in comparison with conventional textbooks, 4th and 5th year medical students of the University of Berne were asked to work through a short programmed text in clinical neurology and to answer questions related to several aspects of using programmed texts and other materials. The analysis of the 212 questionnaires returned (58%) indicates that almost all students considered such a learning experience as highly useful and stimulating, but only about 25 per cent had no reservations. It is concluded that programmed medical texts may be used so little because they require students to learn in a highly standardized way, and because students need additional learning resources which provide them with conceptual framework of and sufficient information about a given area.

Adult↗
PubMed1976

[Presence of the husband in the delivery room (author's transl)].

For the past 7 years a single delivery room was available for all patients in labour. Our unit delivers approximately 1200 babies yearly. It was therefore possible to encourage the husbands progressively to be present during the delivery of their wives. Almost one half of the husbands have since been present during the delivery of their wives. The majority of the couples responded positively to the offer of the husband's presence in the delivery room. 650 couples were extensively questioned following the experience and over 90% of these couples were happy with the experience. Doubtful husbands were advised to remain. Husbands with pronounced aversion against remaining in the delivery room were not persuaded to stay. The husbands had the possibility to leave the room for short breaks and to leave the room during examinations and procedures. Delivery room clothing was supplied. For the psychic benefit of the husband, the husband was kept busy with mild services. Presence of the husband during the actual delivery of the infant was always voluntary since there was no psychologic benefit to remain during the short anaesthesia used during delivery. In many cases husbands who had not even planned to remain stayed during the actual delivery and were very impressed. Late questioning after discharge from the hospital showed that almost all couples valued the experience as positive and planned to have the husband present for the next delivery. The presence of the husband during the delivery of his infant offers a chance for the additional humanization of obstetrics which appears to be very important because of the increasing danger of depersonalization of the labour and delivery process due to the new technology. Presence of the husband during the delivery in the hospital permits a partial return to the "idyllic" state of domicilary obstetrics.

Female↗