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Biomedical subjects

H Nivet

Publications and source records attributed to H Nivet.

66 records · Page 4Linked to original sources
PubMed1980

[Bartter's syndrome: seven cases in siblings. Hypothesis of mild forms (author's transl)].

Three children with a Bartter's syndrome have been investigated: all of them had growth retardation, hypokalemia (less than 3 mmol/l), raised plasma renin activity and urinary prostaglandins (PGE2 and PGF2 alpha) and a decreased sensibility for angiotensin. In the siblings two children had also growth retardation with mild biological signs of Bartter's syndrome, and two children had normal growth slight hypokalemia raised RPA and urinary PH, and normal sensibility for angiotensin. These data suggest mild forms of this syndrome which could be the Bartter's syndrome diagnosed in adults after laxatives or diuretics absorption. Besides these data stated a negative correlation (p less than 0,01) between plasma K+ and RPA, negative correlation (p less than 0,01) between plasma K+ and urinary PGE2 and a positive correlation (p less than 0,01) between RPA and urinary PGE2. From these observations physiopathology of Bartter's syndrome is discussed.

Adolescent↗
PubMed1979

[Hepatitis A of children. Seroepidemiological study among French urban population (author's transl)].

A prevalence survey of hepatitis A antibody (anti-HAV) was conducted among 145 children living in the area of Tours (France). Thirty-four per cent of children's sera was found anti-HAV positive when tested by both immune adherence hemagglutination assay (IAHA) and specific radio-immunoassay (RIA). The prevalence of anti-HAV among infants less than one year and children between 1 to 5 years, was 35 per cent and 15 per cent respectively. From 6 years old, the prevalence of anti-HAV increased abruptly and reached 47 per cent in the 11 to 15 age group. Anti-HAV titers as measured by IAHA also increased according to age. In this study, the prevalence of anti-HAV was not related to sex, history of past surgery and/or blood transfusions. Only 12 per cent of children with anti-HAV positive test had history of jaundice. These results show that, in France, primary contact with hepatitis A virus (HAV) appear early in childhood, at school age, and that in children more than 80% of HAV infections remain asymptomatic.

Adolescent↗
PubMed1979

Immunologically mediated tubulo-interstitial nephritis in children.

14 children with proven or presumably immunologically mediated tubulo-interstitial nephritis are presented. In 2 patients anti-tubular basement membrane antibodies were detected. In 6 immunofluorescence microscopy showed granular deposits of immunoglobulin and/or complement likely representing interstitial location of immune complexes. The findings by immunofluorescence were not significant in the remaining 6 patients. However, the association of renal disease to extra-renal disorders, namely chronic active hepatitis and ulcerative colitis, or uveitis or the presence of an epithelioid granuloma with multinucleated giant cells suggests that in such patients an immunologic disorder might be responsible for the tubulo-interstitial nephritis.

Animals↗
PubMedDate not supplied

[End-stage renal insufficiency in children less than 4 months old. Survey of the French Pediatric Nephrology Club].

One hundred and eleven cases of children with end-stage renal failure prior to 4 years of age were collected from a survey of the French Pediatric Nephrology Club. Clinical and epidemiological data stress the importance of certain etiologies such as 40 cases of renal hypoplasia. The necessity of planning extracorporeal dialysis from the first year of life in 37% of patients demonstrates the importance of difficulties to be overcome. The treatments used for the 82 treated children show the interest of conservative management. However, peritoneal dialysis remains the first treatment of choice (52 times). Besides the problems of hemodialysis vascular approach, related to the small caliber of vessels, the complications of the clearance techniques did not appear to be more frequent than in older children. Use of transplantation is not negligible as 25% of transplanted patients were under 4 years of age; however none was under one year or weighted less than 8 kg. Transplantation remains ultimate treatment, even more so as the actuarial survival at 5 years is clearly worse for children submitted to hemodialysis (68%) than to transplantation (91%) (p less than 0.05).

Combined Modality Therapy↗