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Biomedical subjects

H Niimi

Publications and source records attributed to H Niimi.

At least 217 records · Page 12Linked to original sources
PubMed1980

Evaluation of L-thyroxine requirement in treatment of congenital hypothyroidism.

The optimal daily requirement of L-T4 in replacement therapy for hypothyroidism was evaluated in evaluated in 24 cases of congenital hypothyroidism and 3 of juvenile myxedema, ranging from 3 to 30 years of age. The optimal dose of L-T4, defined as the minimal dose necessary to suppress the serum concentration of TSH into the normal range, was determined in each patient. The optimal dose of L-T4 between 3 and 5 years of age was 5-7 microgram/kg/day, which was higher than a level of 2-4 microgram/kg/day in adult. All patients appeared clinically euthyroid, and their serum concentration of T4 and T3 remained within the normal range while the optimal dose of L-T4 was being administered. These observations imply that physiologic requirement of L-T4 are lower than previously recommended dosages. Further studies to establish more precise therapeutic guidelines are needed.

Adolescent↗
PubMed1978

The role of hemodynamic factors in arterial wall thickening in the rat.

In a study on the pathogenesis of arterial wall thickening, hemodynamic factors in the common carotid artery of the rat were experimentally altered with an autograft. The relationship between flow pattern and wall-thickening was examined in a half-ring bypass model with an induced stenosis, using both flow-visualization in a corresponding in vitro model circuit and observation of the wall by microscopy. Wall-thickening was found in the neighborhood of bifurcations, junctions and curved segments, which corresponded to regions of low-shear in the flow-field. Marked histologic changes in the wall were observed in the post-stenotic segments where the flow field was very disturbed. Histologic changes in the arterial wall correlated well with flow patterns.

Animals↗