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Biomedical subjects

H Niederhoff

Publications and source records attributed to H Niederhoff.

61 records · Page 4Linked to original sources
PubMedDate not supplied

[Orbital phlegmon in childhood].

Between 1970 and 1980 there were 43 patients (28 boys, 15 girls) treated for an orbital cellulitis at the Freiburg University Children's Hospital. The most frequent underlying condition is maxillary or ethmoidal sinusitis. The most frequent causative agents are pneumococci and staphylococci. Vigorous antibiotic treatment with ampicillin, oxacillin, and - if necessary - with chloramphenicol is absolutely considered to be the therapy of choice as compared to any surgical procedure; this holds also true of the more advanced stages of orbital involvement, provided the cellulitis is primarily due to infection and not primarily due to a traumatic lesion of the orbital area.

Adolescent↗
PubMedDate not supplied

[Transient erythroblastopenia].

5 patients 10 to 20 months old with severe normochromic, normocytic anemia and reticulocytopenia are reported. All patients recovered within 10 days to 5 weeks. No steroid therapy was given. Failure to recognize the clinical entity leads to unnecessary diagnostic and therapeutic procedures including the transfusion of blood.

Anemia, Aplastic↗
PubMedDate not supplied

Late form of vitamin K deficiency bleeding in Germany.

BACKGROUND: The evaluation of the disease of vitamin K deficiency bleeding (VKDB). METHOD: 108 reported cases between 1980 and 1990 from Germany. RESULTS: VKDB occurs preferentially (90%) in fully breastfed infants, males are affected nearly twice as often as females. The peak age is four weeks; the majority (79%) of the infants are between three and seven weeks old. 58% of the patients suffer from intracranial bleeding, which results in a total mortality rate of 19% and in neurological damage in 21%. Generally the VKDB occurred suddenly as no warning signs were noticed or they were so insignificant as not to be heeded. In at least 37% of the patients cholestasis was detected. The Quick value was pathologically low in every case. Vitamin K dependent factors were low and PIVKA was detectable, whereas vitamin K independent hemostatic parameters were normal or even elevated. The combination of low Quick value and normal fibrinogen as well as platelet level is a good diagnostic indicator which can be confirmed by administration of vitamin K, after which the Quick value will rise within 30 minutes. Vitamin K prophylaxis reduces the incidence of VKDB from 5.13 per 100,000 births to a tenth of that; single dose oral prophylaxis reduces the risk by a factor of 3.3 and a single parenteral dose by 14.3. Parenteral prophylaxis is more effective in patients with hepatobiliary disorders. Patients who suffered VKDB despite having received vitamin K prophylaxis are older at onset (without prophylaxis 32 days, with oral prophylaxis 37 days, and with parenteral prophylaxis 63 days) and have less intracranial bleeding (35%) than patients who received none (62%). CONCLUSION: Late form of VKDB is a rare but serious disease which can be prevented by VK-prophylaxis.

Blood Coagulation Tests↗