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Biomedical subjects

H Newman

Publications and source records attributed to H Newman.

80 records · Page 5Linked to original sources

Diphenhydramine in insomniac family practice patients: a double-blind study.

One hundred eleven mildly to moderately insomniac patients participated in a double-blind, placebo-controlled study to establish the efficacy of diphenhydramine as an over-the-counter (OTC) sleep aid. A two-week crossover design was employed in which all patients received both diphenhydramine and placebo for one week each. The daily diphenhydramine dose was 50 mg at bedtime. Results obtained indicate that diphenhydramine improved various sleep parameters, including sleep latency, to a significantly higher degree than did placebo. In addition, patients on diphenhydramine reported feeling more restful the following morning and patients preferred the diphenhydramine drug to placebo despite experiencing more side effects. This study thus supports the use of 50 mg diphenhydramine as an OTC sleep aid in the treatment of temporary mild to moderate insomnia.

Adult↗

IVC thrombosis: successful treatment with low dose streptokinase.

Thrombosis of the inferior vena cava (IVC) is an infrequent cause of thrombosis when large series of patients with deep vein thrombosis are examined. It may provide a diagnostic challenge in that lower extremity edema may be absent. The management has varied in published series with different authors recommending anticoagulant therapy (heparin or fibrinolytic therapy), surgical venous thrombectomy, or IVC interruption. We describe a case of IVC thrombosis presenting with pulmonary emboli, successfully treated with low-dose infusional Streptokinase.

Adult↗