Spontaneous and catalyzed isomerizations of the acetamide radical cation.
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Letter↗
Biomedical subjects
H Nedev
Publications and source records attributed to H Nedev.
The
The bimolecular reaction of the CH2CHOH+ enol ion (m/z 44) with acetaldehyde gives a strongly dominant product, m/z 45, formed mainly by proton transfer from the ion to the molecule. The abundance of the product coming from a H* abstraction reaction from the neutral, albeit more exothermic, is negligible. In order to explain this result, the long lived [CH2CHOH*+, CH3CHO] solvated ion was generated by reaction of the CH2CHOH*+ enol ion with (CH3CHO)n in the cell of a Fourier transform ion cyclotron resonance mass spectrometer. The structure of this solvated ion was clearly established. Labeling indicates that [CH2CHOH+, CH3CHO], upon low energy collisions, reacts by H* abstraction more rapidly than by H+ transfer to the neutral moiety. This shows that the entropic factors are determinant when the enol ion reacts directly with acetaldehyde.
Journal Article↗
Opiate-like peptides. Part XI. 2-[2-phenyl-1,3-indandionyl]--amides of enkephalin analogs. Synthesis and analgesic activity.
Four enkephalin analogs containing C-terminal 2-amino-2-phenyl-1,3-indandione residue were prepared: [Met-NHPID5]--enkephalin (E3), [D-Ala2,Met-NHPID5]--enkephalin (E4), [Leu-NHPID5]--enkephalin (E5), [D-Ala2,Leu-NHPID5]--enkephalin (E6). Their analgesic activities were assayed by three in vivo tests: the "hot plate" method, the reaction to electric painful stimulus and the writhing syndrome test. Neurotoxicity effects were determined by the rota-rod test. The most pronounced analgesic effect was induced by compounds with D-Ala in position 2, particularly in the "hot plate" test.
Animals↗