Biomedical subjects
Publications and source records attributed to H Nabai.
Nail abnormalities have been described with dermatologic and nondermatologic systemic diseases. A combination of Muehrcke's lines, Terry's nails, and red lunula with hypoalbuminemia, anemia, and chronic heart failure has not been reported to our knowledge. Our case describes the observations of a physician of his own nail changes about the time he underwent heart transplantation.
BACKGROUND: The clinical appearance of amelanotic lentigo maligna melanoma (ALMM) is quite confusing and usually is not diagnosed prior to histopathologic examination. METHODS: We have studied four new patients with ALMM whose correct diagnosis was not obtained from any one clinical finding. We arrived at the final diagnosis in an unexpected way, having had biopsied the lesions for diagnoses other than malignant melanoma. RESULTS: ALMM presents as a nonspecific skin lesion with no single indicative characteristic. A search of the literature confirmed our difficulty in making the diagnosis. CONCLUSIONS: To diagnose ALMM, one has to be cognizant of this condition and has to consider a constellation of findings that are unusual with melanocytic lesions. Questionable lesions must be biopsied for definitive histopathologic diagnosis.
Saving the physicians time is very desirable in rendering first-rate dermatological service at lower cost. The aim is to reduce surgical instrumentation during skin biopsy procedures and follow-up visits. A combined instrument is used to obtain skin biopsies from 100 patients, and gelatin sponge plugs are used in hemostasis and to assist healing of the biopsy wound site. Skin biopsy samples are obtained simply and with ease, and, as the tissue sample is handled minimally, it appears to be more intact and less distorted in comparison to the usual procedure. Skin biopsy samples can be obtained with the combined instrument in a more cost-effective manner with savings of the physician's time and less instrumentation.
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Chemically induced localized skin depigmentation is not a common observation. We report a case with localized skin depigmentation secondary to the rubber tag of a wrist splint.
Regressing atypical histiocytosis (of Flynn) is a recently described disease that, in spite of histological features of malignancy, seems to run an indolent clinical course. A new case of this rare condition is reported herein.
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We are reporting a case of keratosis lichenoides chronica. This is a chronic dermatosis characterized by seborrheic dermatitis-like facial eruption and purplish papulonodular lesions of the extremities. These lesions sometimes show linear configuration. Histologic changes include features of a chronic and lichenified dermatitis and lichen planus.
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Two cases of recurring digital fibrous tumor of childhood are reported. Both patients were infants who had lesions on the toes or fingers. In one case the lesions recurred after surgical excision and in the other the lesions started to resolve without therapy. The histologic sections of tissue showed the intracytoplasmic inclusion bodies typical of this condition.
2 cases are reported with unusual manifestations of porokeratosis of Mibelli. In 1 case multiple atrophic facial lesions resembled plaques of chronic discoid lupus erythematosus. The second case exhibited extensive cutaneous involvement in the form of hyperkeratotic lesions in linear configuration.
Four children with cutis laxa (generalized elastolysis) are reported. The first three cases were siblings from a Canadian Indian family and the fourth case was the only affected child in an American Black family. Loose and sagging skin folded over the face, neck and trunk, gave a premature senile appearance. Post-mortem examination was performed on the first three cases. The most common and serious visceral involvement was development of pulmonary emphysema. This was present in two autopsied cases and was demonstrated by chest X-ray in the fourth case. Other abnormalities included large inguinal and perineal hernia, rectal diverticulum and multiple diverticulae of the urinary bladder.
A child with Winchester syndrome, studied in Iran, is the sixth reported case in the literature. The cutaneous manifestations of this syndrome include leathery thickening of the skin, hyperpigmentation and hypertrichosis. The lips and gingiva are hypertrophic. There are also arthritic changes involving the small joints.
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