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Biomedical subjects

H Muratani

Publications and source records attributed to H Muratani.

77 records · Page 5Linked to original sources
PubMed1982

Pseudoxanthoma elasticum associated with Hashimoto's thyroiditis.

A case of pseudoxanthoma elasticum (PXE) associated with Hashimoto's thyroiditis is reported. A 49-year-old woman had typical skin lesion of PXE and ocular lesions such as angioid streaks, peau d'orange pattern and subretinal bleedings. She also had a goiter for which histological examination revealed the findings of Hashimoto's thyroiditis. Antithyroidal autoantibodies were positive. Many members of her family for three generations back have had the ocular lesions of PXE, however, they did not have any findings supporting Hashimoto's thyroiditis. The present report was considered to be the first case of PXE associated with an immunological disorders.

Angioid Streaks↗
PubMedDate not supplied

Brain angiotensin and circulatory control.

1. Components of the renin-angiotensin system (RAS) are found in the brain; both outside and inside the blood-brain barrier. 2. Almost all of the classical actions of the brain RAS are attributable to angiotensin (Ang) II and mediated by AT1 receptors. 3. Circumventricular organs (CVO), which lack the blood-brain barrier, are rich in AngII receptors and monitor circulating AngII levels. In vivo binding studies suggest that the CVO are also accessible to cerebrospinal fluid-derived AngII. 4. The median preoptic nucleus, paraventricular hypothalamic nucleus, supraoptic nucleus, nucleus tractus solitarius and ventrolateral medulla are inside the blood-brain barrier and are sites of action of brain AngII. In these nuclei, AngII seems to act as an excitatory neurotransmitter or neuromodulator. 5. Actions of AngII in the brain, both inside and outside the blood-brain barrier, are implicated in the central regulation of blood pressure and sympathetic outflow, release of hypothalamic and pituitary hormones and renal sodium handling. 6. Alterations in the activity of brain AngII may be involved in the mechanisms of some types of hypertension.

Angiotensin II↗
PubMedDate not supplied

Aminoglutethimide effect on circadian rhythms in urinary variables in a patient with idiopathic hyperaldosteronism.

Aminoglutethimide (AG: 750 mg/day) was administered to a patient with idiopathic hyperaldosteronism (IHA) and circadian rhythms in urinary excretion of sodium (UNaV), potassium (UKV), aldosterone (AER) and 17-OHCS were analyzed by the single cosinor method. Urine was collected every 4h for 24h on the day before and on the 1st, 3rd and 7th day of AG administration, and above variables in each sample were determined. Circadian rhythms of 14 patients with primary aldosteronism (PA) who served as controls were also analyzed. In the present case, circadian acrophases in UNaV and AER studied before AG administration occurred at 22(19) and 07(05), respectively. They were similar to those of preoperative PA-patients. Circadian acrophase in UNaV occurred earlier with AG administration and on the 7th day it was at 14(05), a value similar to that of postoperative PA-patients. Circadian mesor in AER decreased remarkably from 4.1 to 0.6 micrograms/4h with AG administration, as did circadian mesor in UKV, whereas circadian mesor and acrophase in 17-OHCS did not change. Thus, the circadian characteristics in urinary variables in the present IHA-case were pathophysiologically similar to those of PA.

17-Hydroxycorticosteroids↗