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Biomedical subjects

H Muranaka

Publications and source records attributed to H Muranaka.

At least 55 records · Page 3Linked to original sources
PubMed1982

Biological activity of des-asp1-des-arg2-angiotensin II in man.

The biological activity of des-asp1-des-arg2-angiotensin II (3-8AII) was studied in man. When 3-8AII was infused iv at rates of 22 and 308 pmol (17.5 and 250 ng)/kg . min separately into 5 normal men each for 120 min, blood pressure showed no change, plasma renin activity (PRA) decreased gradually and plasma aldosterone showed a gradual slight increase. The lower dose of 3-8AII partially inhibited captopril-induced PRA increase and plasma aldosterone decrease in the same 5 normal men and the higher dose of the hexapeptide completely abolished them. In one of the 5 normal men blood pressure rose in response to doses of 3-8AII greater than 2220 pmol (1750 ng)/kg . min. When 3-8AII was infused iv at 308 pmol/kg . min into 2 patients with Bartter's syndrome for 60 min, it caused marked decrease in PRA and plasma aldosterone but no change in blood pressure. This decrease in plasma aldosterone is thought to be secondary to the decrease in PRA. From these results it is evident that 3-8AII has a minimal pressor action, a weak aldosterone-stimulating action and a significant renin-suppressing action in man and this PRA-lowering action is thought to be due to direct inhibition of renin release by its whole molecule or a smaller part of the molecule.

Adult↗
PubMed1979

Effect of pH and urine flow on urinary nicotine excretion after smoking cigarettes.

Effects of pH and urine flow on urinary excretion of nicotine were examined in 11 smokers after they had smoked 3 cigarettes during water diuresis. Plasma nicotine showed a slight but nonsignificant rise after smoking. Urinary excretion of nicotine increased significantly from the pre-smoking levels of 258 +/- 76 and 252 +/- 147 (mean +/- SEM) ng/15 min to the peaks of 2,587 +/- 1,224 and 2.561 +/- 584 ng/15 min 30 and 45 min after the start of smoking. Thereafter, urinary nicotine tended to decrease and rise with changes in urinary flow. There was a correlation between urinary nicotine and urinary flow after smoking (r = 0.26, p less than 0.05). Eleven subjects were grouped based on the mean urinary pH throughout the experiment. No significant amount of nicotine was excreted in the group with pH above 7.5 while groups with pH below 7.4 excreted substantial nicotine after smoking. There was a negative correlation between urinary pH and nicotine excretion (r = -0.58, p less than 0.001). Urinary excretion of nicotine cannot be used as an index of smoking unless pH and urine flow are controlled.

Adult↗
PubMed1979

Intramedullary spinal cysticercosis.

Intramedullary cysticercosis of the spinal cord is rare; there have been only 26 previous cases. We describe a patient with low back pain, paraparesis, lumbosacral sensory loss, and signs of meningeal irritation. The clinical diagnosis was spinal cord tumor, but at surgery there was a cysticercus cyst within the lumbosacral cord. Careful search did not reveal the parasite in any other part of the body. This is the first case of spinal cysticercosis reported in Japan.

Adult↗