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Biomedical subjects

H Moser

Publications and source records attributed to H Moser.

183 records · Page 11Linked to original sources

[Determination of the origin of drugs by measuring natural isotope contents: D/H and 13C/12C ratios of some diazepam samples (author's transl)].

The precise determination of the natural isotopic abundance ratios of carbon and hydrogen in several production batches of the commercial product 7-chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-on (diazepam) gave results which allowed certain batches to be differentiated. The differences in the ratios appear to be mainly due to differences in the isotopic composition of the (fossile) starting materials of the synthesis. The measurement of the natural isotopic ratios may therefore offer another possibility to determine the origin of a drug.

Carbon Isotopes↗

[Prenatal diagnosis of osteogenesis imperfecta, type II, following AID].

Osteogenesis imperfecta is a severe disorder of skeletal formation with nonuniform mode of inheritance. Insufficient bone formation in severe cases (Type II and III) leads to spontaneous intrauterine fractures with shortening of the extremities and thoracic deformities. Sonographical, radiological, pathological-anatomical and clinical data are presented and discussed in a case which was diagnosed at the 19. week of pregnancy.

Adult↗