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Biomedical subjects

H Morr

Publications and source records attributed to H Morr.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Primary malignant fibrous histiocytoma of the lung].

A chance finding of a sheet-like, dorsal opacification in the left lower lung field of a 77-year-old nonsmoking woman was at first misdiagnosed as tuberculosis because mycobacteria were demonstrated in bronchial secretion. Before it was shown that they were atypical mycobacteria, only facultatively pathogenic, tuberculostatic treatment was started. But both radiologically and clinically the patient's condition deteriorated, with fever and enlargement of the pulmonary lesion. The left lower lobe was resected on suspicion of a chronic pneumonia with consolidation and ultimately abscess formation. The preliminary histological diagnosis of the resected lobe was of a small-cell bronchial carcinoma, stage pT3N0Mx. Further immunohistochemical tests, however, revealed a malignant fibrous histiocytoma which is extremely rare in the lung.

Aged↗
PubMed1983

Anti-allergic effect of beta-2 agonists and cholinoceptor antagonists in vitro.

Human lung tissue passively sensitized with anti-grass pollen IgE antibodies releases histamine upon exposure to specific grass pollen antigen. Beta-sympathomimetic agents inhibit the antigen-induced release of histamine, thus beta-sympathomimetic drugs might exhibit a combination of prophylactic and direct bronchodilating properties in the treatment of allergic bronchial asthma. The anticholinergic agent ipratropium bromide had no direct effect on the immunologically induced release of histamine. Acetylcholine increased the antigen-induced release of histamine significantly. This enhanced release was almost completely inhibited by ipratropium bromide as a result of competitive inhibition. This mode of action may add to the usefulness of anticholinergic agents in vagus-controlled chronic obstructive ventilatory disorders.

Asthma↗
PubMed1982

[Diagnostic value of carcinoembryonic antigen in pleural fluid (author's transl)].

Of 30 unselected patients with pleural effusion of unknown cause 17 were subsequently found to have malignant disease of the pleura. In 11 of the 17 patients the concentration of carcinoembryonic antigen (CEA) in the pleural effusion was elevated to 4-60 ng/ml. In all 13 patients with pleural effusion of non-malignant cause the CEA concentration was normal (0-2 ng/ml). While the specificity of CEA antigen was 100% in the diagnosis of malignant pleural disease, its sensitivity was only about 65%. Since low CEA values in pleural effusion thus cannot exclude malignant disease with certainty, histological assessment of the pleural disease should be practised in every case where tumour is suspected, if necessary via thoracoscopy or thoracotomy.

Adult↗
PubMed1982

[Current aspects of bronchial asthma (author's transl)].

Immunologically mediated diseases of the lung and the bronchial system, in specially allergic bronchial asthma have reached increasing clinical significance. The importance of the immediate allergic reaction for pathogeneses, diagnosis and therapy is pointed out and discussed under the aspect of recent findings.

Antibody Formation↗
PubMed1979

[Histamine levels in blood of patients with allergic bronchial asthma (author's transl)].

The investigation of 10 patients with allergic asthma showed histamine levels of 79.8 +/- 50.0 ng/ml in blood during symptom-free intervals. They were not significantly different from those in 12 patients with chronic obstructive bronchitis (54.0 +/- 25.9 ng/ml) and in 13 healthy probands (56.9 +/- 21.5 ng/ml). It could be shown that allergen-induced bronchial obstruction in patients with allergic asthma had no demonstrable influence on blood histamine levels. The absence of increased blood histamine levels in allergic bronchial obstruction supports the assumption that allergen-induced liberation of histamine and its biological effects are mainly limited to the bronchial system. Local metabolisation of the liberated mediator can be supposed to a large extent.

Adult↗
PubMed1979

Influence of inhalation anaesthetics on bronchomotor tone--animal experiments on vago-vagal reflex bronchoconstriction.

Animal experiments showed that the inhalation anaesthetic agents enflurane and halothane caused neither a direct increase in bronchial resistance nor an indirectly mediated increase in the susceptibility of the bronchial system to acetylcholine. There are, therefore, no contraindications to the clinical use of enflurane and halothane in cases of obstructive airway diseases, nor does the use of these agents present an increased risk for these patients.

Anesthesia, Inhalation↗