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Biomedical subjects

H Moltz

Publications and source records attributed to H Moltz.

At least 55 records · Page 3Linked to original sources
PubMed1976

Changes in the metabolism of hypothalamic norepinephrine associated with the onset of maternal behavior in the nulliparous rat.

Both norepinephrine (NE) and its major metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), were assayed both in the hypothalamus of nulliparous rats that had behaved maternally toward foster young and in the hypothalamus of those that had failed to behave maternally. It was found that the maternally-behaving animals had both lower concentrations of NE and higher concentrations of MHPG as compared with their nonresponding counterparts. These data parallel those reported for the puerperal female and suggest that the onset of maternal behavior may be mediated by increased transmission across hypothalamic noradrenergic synapses.

3-Methoxy-4-hydroxyphenylethanol↗
PubMed1975

Hypothalamic norepinephrine: concentration and metabolism during pregnancy and lactation in the rat.

Both norepinephrine (NE) and its major metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), were assayed in rat hypothalamus during selected stages of pregnancy and lactation. No changes were observed in the concentration of either NE or MHPG at 5, 15 or 21 days' gestation. However, with 8-15 h after parturition, the concentration of NE decreased sharply while that of MHPG showed a correspondingly sharp increase. The possible significance of such change in hypothalamic catecholamine activity was considered in relation to parturition, postpartum estrus and onset of maternal behavior.

Animals↗
PubMed1973

Maternal behavior in the rat: facilitation through gonadectomy.

Virgin rats were ovariectomized and tested for induction of maternal behavior by being housed with neonatal young. A postoperative interval of 8 weeks yielded an average latency for the onset of maternal behavior significantly lower than that for intact controls or for virgin females ovariectomized 4 weeks before testing. Replacement of estrogen in the group ovariectomized for 8 weeks or injection of the estrogen antagonist ethamoxytriphetol (MER-25) in the group ovariectomized for 4 weeks changed the average latencies accordingly. Parallel results were obtained for males that were castrated 4 or 8 weeks before testing. It is concluded (i) that maternal behavior is under gonadal control and that this control is normally inhibitory; and (ii) that only after long-term removal of the gonads, resulting presumably in the complete clearance of estrogen and testosterone, is the maternal mediating system finally released from steroid suppression.

Animals↗
PubMed1969

Prolactin in the postpartum rat: synthesis and release in the absence of suckling stimulation.

Postpartum female rats deprived of suckling stimulation while being kept continuously with pups nonetheless suspended ovarian cyclicity for an average of 16 days and responded to uterine trauma by forming deciduomata. These results show that the extramammary stimulation afforded by young is alone capable of sustaining prolactin output from the adenohypophysis of the postpartum rat.

Animals↗