We report successful treatment of acute severe Budd-Chiari syndrome with portal venous thrombosis. The prognosis of patients with this condition is poor, because the therapeutic options are limited. A 38-year-old woman with polycythemia vera was admitted in a critical condition, and Budd-Chiari syndrome complicated by portal venous thrombosis was diagnosed. Tissue plasminogen activator and urokinase were infused systemically and were partially effective. Transjugular intrahepatic portosystemic shunting to reduce the high portal venous pressure was performed successfully and, eventually, her general condition improved. Our experience indicates that emergency transjugular intrahepatic portosystemic shunting is an effective therapeutic modality for controlling portal hypertension in patients with severe Budd-Chiari syndrome with portal venous thrombosis.

Adult↗

PubMedDate not supplied

Effects of 2,3-dibenzylbutane-1,4-diol on vascular smooth muscle of rabbit aorta.

We investigated the effects of 2,3-dibenzylbutane-1,4-diol (DBB), a mammalian lignan derived from human urine, on the contractile response and the 45Ca2+ uptake in the vascular smooth muscle of rabbit aorta. In resting state, DBB did not influence the tension and the 45Ca2+ uptake. DBB inhibited the high KCl- and the CaCl2-induced contraction in the partially depolarized muscle strip. DBB inhibited the noradrenaline- and the angiotensin II-induced contraction, but not the transient contraction evoked by noradrenaline in Ca2+-free solution. DBB completely inhibited the 45Ca2+ uptake induced by high KCl or noradrenaline. These results indicate that DBB inhibits the Ca2+ influx but not the Ca2+ release from the Ca2+ stores.

Angiotensin II↗