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Biomedical subjects

H Mishina

Publications and source records attributed to H Mishina.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Combined radiotherapy and chemotherapy for the treatment of esophageal cancer].

Eight patients with esophageal cancer were treated by a new treatment schedule consisting of low dose irradiation, crescendo cisplatin and bleomycin polyacrylate pasta. As monitored endoscopically, therapeutic responses were satisfactory: seven out of 8 patients have survived for a range of 3 to 20 months and still active at work or cancer-free. However, one patient suffered from a second malignancy of adenocarcinoma of the upper esophagus different from the initial squamous cell carcinoma at the lower esophagus which had successfully been treated 3 months before. The present therapeutic design aims at treatment of lymphatic spreads in the adjacent structures as well as the original tumor in the esophagus and submucosal invasions. It is basically a consecutive, multimodal integration of selective concentration of therapeutic effects (extensive radiotherapy, topical application of bleomycin polyacrylate pasta, lymphatic chasing with colloidal bleomycin, and spatial concentration of cisplatin as the result of radiation-induced inflammation), perpetuation of the repairable DNA damage, and biological amplifications (protection against esophageal perforation with polyacrylate coating, and specific cancer cell recruitment). Application of the present therapeutic design is being expanded to the treatment of cancer of other specific sites such as the head and neck tumors and rectal cancer with undeniable prospects.

Adenocarcinoma↗
PubMed1983

[Case of malignant fibrous histiocytoma associated with squamous cell carcinoma of the esophagus].

A 46-year-old male was admitted complaining of swallowing disturbance. Esophagogram demonstrated a polypoid mass 15 cm in length at the mid portion of the esophagus. Esophagofiberscopy revealed a large greenish friable mass. Subtotal esophagectomy, cervical esophago-gastrostomy and lymph node dissection were performed. The resected polypoid mass was elliptical and measured 14 X 4 X 4 cm. The histological diagnosis of the pedunculated mass was Malignant Fibrous Histiocytoma. An area of poorly differentiated squamous cell carcinoma, in the mucosal layer, was present at the stalk of the polypoid tumor. Lymph nodes showed no tumor involvement.

Carcinoma, Squamous Cell↗
PubMed1982

Probable atherogenic role of zinc and copper as studied in chronic hemodialysis patients.

The relationship of lipoperoxidemia and HDL-cholesterolemia to circulating zinc and copper was investigated in patients undergoing chronic hemodialysis. When the serum zinc level was low and the copper level was high, or when the zinc, copper ratio was low, decreased concentrations of HDL-cholesterol were observed. In view of the high incidence of atherosclerosis among patients undergoing chronic hemodialysis, zinc and copper may somehow contribute to atherogenesis by affecting the serum HDL-cholesterol concentrations.

Adult↗
PubMed1982

Amogastrin for the 99mTc-pertechnetate imaging of the gastric mucosa.

Most of the gastric diseases seat in the mucosa, and the present investigation was undertaken in order to see if amogastrin, a synthetic tetrapeptide, was capable of enhancing gastric accretion of intravenous 99mTc pertechnetate in man as well as in the rabbit. Improvement of gastric scintigraphy was achievable with a pretreatment of the agent by increasing the gastric accretion and reducing the background radioactivity in the liver and small intestinum.

Adult↗
PubMed1981

Probable superoxide therapy of experimental cancer with D-penicillamine.

A sublethal dose of D-penicillamine (DP) induced hyperlipoperoxidemia and hypocupremia in old rats. Treatment of cancer cells in vitro and in vivo with DP resulted in appreciable suppression of cell multiplication and a remarkable inhibition of tumor growth. Erythropoiesis did not seem to be affected by DP. The selective effect of DP seems to have resulted from the reduced superoxide dismutase activity and/or defective Mn superoxide dismutase.

Animals↗