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Biomedical subjects

H Minkoff

Publications and source records attributed to H Minkoff.

100 records · Page 6Linked to original sources
PubMed1985

Fetal heart rate decelerations after oxytocin infusion in an abdominal pregnancy.

Fetal heart rate (FHR) decelerations during a contraction stress test are recognized as signs of possible uteroplacental insufficiency. Although these decelerations have been described commonly in intrauterine pregnancies, they have not been noted in extrauterine pregnancies. Reported herein are FHR decelerations associated with oxytocin infusion in an extrauterine pregnancy and a discussion of the possible pathophysiologic mechanisms.

Adult↗
PubMed1984

Risk factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy.

Prematurity remains a major cause of perinatal mortality in the United States. Some research has indicated that infectious agents play a role in either initiating preterm labor, causing premature rupture of the membranes, or preventing tocolysis. This study attempted to determine if the presence of various vaginal pathogens in early pregnancy was associated with the subsequent development of premature rupture of membranes or preterm labor. We found that among 233 evaluable patients those with Trichomonas vaginalis were significantly more likely to have premature rupture of the membranes (p less than 0.03), and those with Bacteroides sp. were more likely to be delivered of their infants before 37 weeks (p less than 0.03) and to have infants weighing less than 2500 gm (p less than 0.05). Those with Ureaplasma urealyticum more frequently began preterm labor (p less than 0.05). Preterm premature rupture of the membranes was found significantly more often among patients with Bacteroides sp. Stepwise multiple logistic regression analysis indicated that those associations were not related to the number of previous abortions, deliveries, or preterm deliveries or to maternal age. We conclude that microbiologic screening in early pregnancy may aid in the assessment of patient risk for preterm delivery.

Adolescent↗
PubMed1983

The relationship of maternal antibody levels to post-cesarean section endometritis.

One hundred eight pneumococcal polysaccharide antibody levels were determined by radioimmunoassay preoperatively in 18 patients who underwent elective repeat cesarean section. Eight patients developed post-cesarean section endometritis, and 10 did not. The endometritis group did not vary significantly from the noninfected group in preoperative hematocrit, social status, number of previous pregnancies, maternal and newborn weights, length of operation, and Apgar scores. Mean antibody levels in the endometritis group were significantly lower than those in the control group (49 versus 103 ng/ml; p less than 0.05). Mean antibody levels for the six serotypes in the endometritis group were significantly lower than those in the control group (p less than 0.05). This study indicated that a healthy maternal immune system may play an important role in preventing post-cesarean section morbidity. Pneumococcal polysaccharide antibody levels may be used in pregnancy to assess the risk for post-cesarean section infections.

Adult↗
PubMed1983

Hepatitis.

Explore the source record for details and available documents.

Carcinoma, Hepatocellular↗
PubMed1983

Prematurity: infection as an etiologic factor.

Preterm delivery accounts for a substantial percentage of perinatal mortality and morbidity. A large body of evidence suggests that perinatal infections may play an etiologic role in preterm rupture of membranes and preterm labor. The interaction between a patient's vaginal flora and her local defense mechanisms (antibacterial activity of amniotic fluid and cervical mucus) may help determine who delivers prematurely. The evidence implicating infection as a cause of labor is reviewed, and the organisms which may be responsible are identified. Potential avenues of investigation and intervention are outlined which would delineate the role of infections in preterm delivery and lead to a means of preventing some preterm deliveries caused by infection.

Bacterial Infections↗
PubMed1983

The medical significance of the obstetric history.

A carefully obtained obstetric history can provide the family physician with useful clues to his patients' health risks. A previous infant's birth weight and certain congenital malformations may indicate a predisposition to vascular hypertensive or diabetic illness. Additionally, if the family physician knows when his patients are planning pregnancies, he can help reduce exposure to teratogens during early pregnancy by discontinuing medications such as warfarin and phenytoin, by controlling blood glucose levels in diabetics and by counseling against the use of alcohol and tobacco.

Breast Neoplasms↗
PubMed1982

Management of the breech second twin.

The risk of vaginal delivery of breech infants is well documented and reflected in a high cesarean section rate for those infants. We also found that, among sets of twins delivered between 1970 and 1977, breech first twins were significantly more likely to be delivered by cesarean sections than were vertex first twins. Breech second twins, however, did not have a cesarean section rate significantly higher than that of vertex second twins. The data did not justify a less frequent use of cesarean section for breech second twins. There was no significant difference in perinatal mortality rates or Apgar scores between breech first and second twins, and cesarean sections improved the outcome equally for breech first and second twins. Breech infants, whether first or second, fare worse than vertex infants. Therefore, appropriate management of twins in labor should include determination of the presentation of the second twin and use of the same indications for cesarean section for both first and second twins in breech presentation.

Apgar Score↗
PubMedDate not supplied

The relationship of vaginal trichomoniasis and pelvic inflammatory disease among women colonized with Chlamydia trachomatis.

BACKGROUND: Trichomonas vaginalis is a common sexually transmitted pathogen that has been linked to upper genital tract bacterial disease. Its association with upper tract chlamydial disease has not been assessed. GOAL OF THIS STUDY: This study was undertaken to determine whether women colonized with Chlamydia trachomatis who are also infected with Trichomonas vaginalis are at increased risk for having pelvic inflammatory disease. STUDY DESIGN: A nested case control methodology was used to compare Trichomonas vaginalis rates between women colonized with Chlamydia trachomatis who had pelvic inflammatory disease (n = 24) and those who were colonized but did not have pelvic inflammatory disease (n = 47). Factors that might be related to the development of upper tract disease (e.g., douching, other sexually transmitted diseases) and factors linked to colonization with Trichomonas vaginalis (e.g. race, use of oral contraceptives) were assessed. RESULTS: When exact logistic regression models were used and variables associated with pelvic inflammatory disease were considered, it was found that age (odds ratio = 0.73; P = .001) and Trichomonas vaginalis colonization (odds ratio = 4.72; P = .053) were significant. CONCLUSIONS: In this preliminary study of women colonized with Chlamydia trachomatis, an association was found between co-infection with Trichomonas vaginalis and evidence of upper tract disease.

Adult↗