Biomedical subjects

H Mimura

Publications and source records attributed to H Mimura.

151 records · Page 9Linked to original sources

PubMedDate not supplied

Evaluation of hepatic functional reserve in rats with obstructive jaundice by asyaloglycoprotein receptor.

BACKGROUND/AIMS: Until now, there has been no adequate means of evaluating the liver functional reserve in cases with obstructive jaundice. 99mTC-GSA (99mTechnetium-DTPA-Galactosyl-human serum albumin) is a new liver-imaging agent which binds specifically to the asyaloglycoprotein-receptor on the membrane of hepatocytes. So, the liver imaging by GSA excludes the influence of the reticuloendothelial system. Therefore, the uptake of 99mTC-GSA is considered to be a useful method for the estimation of liver functional reserve in cases with obstructive jaundice. METHODOLOGY: In this study, we examined the uptake rate and specific binding capacities of 99mTC-GSA to receptors on the membrane of hepatocytes following 1, and 2 weeks of bile-duct ligation and 1 week after reduction of jaundice using the rat model. RESULTS: The hepatic uptake rate decreased as the period of jaundice was prolonged and returned to nearly normal by the reduction of jaundice. The value of specific binding capacities at 2 weeks after bile-duct ligation decreased significantly compared to the value of the control and the reduced group (P < 0.05). The cause of decrease in specific binding capacities was indicated as the decrease of affinity constant especially in the high affinity part. These results coincide with the change of binding capacities of insulin and glucagon receptors with obstructive jaundice, which accurately reflect the severity of hepatocyte injury. CONCLUSIONS: Taking together these results, 99mTC-GSA liver scintigraphy is thought to be a useful method to evaluate the liver functional reserve in cases with jaundice.

Albumins↗

PubMedDate not supplied

Confirmation of dialysate leakage by intraperitoneal administration of radioactive colloid.

A 29-year-old man who had been on continuous ambulatory peritoneal dialysis (CAPD) was admitted to our hospital because of pleural effusion. Radioactive colloid studies with intraperitoneal administration revealed a pleuroperitoneal communication. After pleurodesis by the administration of fibrin glue and antiplasmin into the thoracic cavity, the pleural effusion did not reaccumulate and there was no evidence of pleuroperitoneal communication by radioactive colloid study.

Adult↗

PubMedDate not supplied

Effects of ulinastatin on polymorphonuclear leukocyte elastase and interleukin 6 levels after hepatectomy.

Eight patients undergoing hepatectomy received 15 x 10(4) U of ulinastatin during and after surgery and then twice daily for 4 days, and 11 hepatectomized patients served as untreated controls. Between-group differences in age, duration of surgery, volume of blood loss and transfusion, weight of resected liver, and results of preoperative liver function tests were not significant. On postoperative day 1, mean (+/- SD) polymorphonuclear leukocyte elastase levels were significantly lower in the treated patients than in the controls (310 +/- 69 micrograms/L vs 519 +/- 382 micrograms/L; P < 0.05); interleukin 6 levels also tended to be lower in the treated patients than in controls (42.4 +/- 34.0 pg/mL vs 63.3 +/- 43.1 pg/mL). The results indicate that ulinastatin has beneficial effects on host defenses after surgery.

Alanine Transaminase↗

PubMedDate not supplied

Needle tract implantation of hepatocellular carcinoma after ultrasonically guided needle liver biopsy: a case report.

Cancer spread along the needle tract following fine needle biopsy is reported to be a rare complication. We report a case of subcutaneous implantation of hepatocellular carcinoma (HCC) following ultrasonically (US)-guided fine needle liver biopsy. The patient, a 53-year-old male was found to have a HCC at the medial segment of the liver confirmed by fine needle biopsy. Three year and four months after segmentectomy, the patient felt a subcutaneous growing lump at the previous biopsy site. The tumor was resected and confirmed histologically as HCC. We herein document other reports of such an occurrence following fine needle biopsy of HCC in Japan and consider this problem in liver biopsies.

Biopsy, Needle↗

PubMedDate not supplied

Role of angiography in carcinoma of the pancreas as a preoperative assessment.

BACKGROUND/AIM: One of the most important factors effecting the prognosis of pancreatic cancer is successful resection of the carcinoma. Proper staging is essential to such resections. This study attempts to prove the importance of angiographic diagnosis for surgery of the pancreas due to ductal carcinoma. Such diagnosis influences the determination for resection, which in turn impacts patient prognosis. MATERIAL AND METHODS: Angiograms of 54 patients who underwent extended pancreatectomy for ductal carcinoma were reviewed. Findings of the angiograms and portograms were classified to four types from the viewpoint of the grade of carcinoma invasion. The angiograms were then compared with pathological determination of carcinoma invasion and the results were compared with patient prognosis. RESULTS: When arterial invasion was not detectable or limited to intrapancreatic small branches, curative resectability and longer survival rates were expected. In patients with invasion to major arteries adjacent to the pancreas, some patient survival rates were significantly longer than others. CONCLUSION: We overestimated the degree of carcinoma invasion based on arteriography so often that we were not disappointed when aiming for curative resection even when contraindicated by arteriography. Angiography had an important role as a preoperative assessment in carcinoma of the pancreas in terms of curative resectability and survival expectancy.

Angiography↗

PubMedDate not supplied

Interruption of hepatic arterial blood flow after resection of pancreaticobiliary carcinoma.

BACKGROUND/AIMS: We reviewed 17 cases of patients with interrupted hepatic arterial blood flow to determine the effect of such an interruption. MATERIALS AND METHODS: In 17 patients undergoing radical resection of pancreaticobiliary carcinoma with simultaneous hepatic artery excision (n=15) or intraoperative hepatic artery obstruction (n=2), morbidity and mortality were reviewed. Nine hepatic artery anastomoses were performed in 7 of these patients, and postoperative patency was obtained for 5 anastomoses. The patients were classified into the following groups: group I was 6 patients with complete interruption of hepatic arterial flow to the whole liver or the remnant liver, group II was 6 patients with interruption of hepatic arterial flow to a lobe of the liver, and group III was 5 patients with preservation of hepatic arterial flow. RESULTS: Disruption of the bilioenteric anastomosis occurred in all 6 patients from group I versus none of those in groups II and III (p<0.05). Liver abscess and liver failure developed in 1 patient each from group I, but the mortality rate in this group was not high. CONCLUSIONS: Hepatic artery reconstruction in patients with complete interruption of hepatic arterial blood flow appears to be necessary to avoid ischemic breakdown of the bilioenteric anastomosis.

Anastomosis, Surgical↗

PubMedDate not supplied

Experimental evaluation of hepatic functional reserve using 111In colloid for clinical application.

We have postulated that reduced hepatic blood flow is the primary factor responsible for postoperative hepatic insufficiency, and have shown the usefulness of the hepatic blood flow index (KL) estimated by 198Au colloid. However, 198Au colloid has became unavailable due to its intense exposure activity. Therefore, we prepared 111In colloid as a substitute for 198Au colloid to evaluate hepatic functional reserve. In the present study, a 111In colloid was administered to rats to investigate the possibility of clinical application. First, liver cirrhosis was induced in rats using CCl4 Changes in KL and hepatic tissue blood flow were measured by hydrogen gas clearance (HL) after CCl4 injection, and was shown to correlates well with it. The correlation between KL and HL, together with normal and cirrhotic liver, was significant (r = 0.83, p < 0.01) Second, reticuloendothelial function was modulated with Zymosan A (stimulation) and Silica (suppression). The KL value remained unchanged in spite of the addition of an activator or suppressor to the reticuloendothelial system. Third, 30% and 70% hepatectomy models were studied according to the method of Higgins-Anderson. KL and HL was measured before and 1, 3 and 7 days after hepatectomy. KL and HL after 30% and 70% hepatectomy showed similar changes. These results indicate that the clearance of 111In colloid can be used clinically as an index of the hepatic blood flow.

Animals↗