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Biomedical subjects

H Milon

Publications and source records attributed to H Milon.

At least 127 records · Page 7Linked to original sources
PubMed1978

Caffeine concentrations in mice plasma and testicular tissue and the effect of caffeine on the dominant lethal test.

Large groups of male Swiss mice received per os on average 100 mg caffeine per kg body weight per day for 1 or 8 weeks. The dominant lethal test was designed to achieve maximum sensitivity in order to detect any possible mutagenic effect. No mutagenic induction of dominant lethals, pre-implantation egg loss or depression of the fertility of females, caused by caffeine at the dose levels administered were observed. The half life of caffeine, which was between 2.5 and 3 h, was similar in plasma and testicular tissue. It was concluded that caffeine did not accumulate in the testicular tissue of mice. The maximum concentration of caffeine found was below 10 microgram/g testicular tissue, which is about a 100 times lower than concentrations that cause chromosome aberrations in cultured mammalian cells.

Animals↗
PubMed1978

[Prognosis of adult angina pectoris by means of blood pressure and the electrocardiogram].

One hundred and fifty-three men with angina were studied to determine the risk of death over a 5-year period. Multivariate analysis using age, systolic and diastolic pressure, and six electrocardiographic variables (QRS axis, PR interval, the sum of S in V1 and R in V5, T-wave and ST segment anomalies and incomplete left bundle branch block) identified sub-groups having very different prognoses. An analysis using only six variables (omitting diastolic pressure, ST segment anomalies and PR interval) retained a good discriminatory value, and this same discriminant function calculated from half of the sample had good prognostic value in the other half. A prognostic index based on this function (designed to simplify the calculations in clinical use) identified a sub-group (24% of the total group) in which no mortality occurred, while another sub-group (16% of the total group) suffered a mortality of 67%. The logical use of the blood pressure and ECG leads to a more precise prognosis in angina and should help in determining the indications for myocardial revascularisation.

Age Factors↗
PubMed1978

[Reducing the burden of hypertension on the community. From control to prevention (author's transl)].

Hypertension is a powerful and widespread cardiovascular risk factor, that can be effectively treated, but is still considerably undertreated. Better control of hypertension could be achieved by enhancing case finding, stimulating antihypertensive drug prescription, and improving patient compliance through a better doctor-patient relationship. Whatever the effectiveness of the current programmes of control of hypertension in the community, it remains to develop a preventive approach based on reducing salt intake and preventing overweight in young adults.

Adolescent↗
PubMed1977

[The late results of aorto-coronary by-pass surgery. Minimum of 4 years follow-up (author's transl)].

Of 340 patients undergoing aorto-coronary surgery over a period of 6 years, the 136 cases in which there was a minimum follow-up of more than 4 years were analysed from the standpoint of the results. Overall amount annual postoperative mortality was low, less than 2,5%, even though the majority of patients undergoing surgery suffered from rest angina and had double or triple coronary stenoses. Analysis of prognostic parameters reveals the importance of the quality of the left ventricule, whilst age, sex, risk factors, the site of the bypass, the number of stenoses and the type of angina had little or no statistical influence on postoperative mortality. Six years after operation, there remained 66% of excellent results and 60% of the patients were able to work. One hundred and forty eight follow-up coronary arteriograms were carried out (including 33 repeated). During the first year after operation (184 by-passes examined) the percentage of permeability of the grafts was 84,8%. Later (86 bypasses examined) this fell significantly to 74,4% but 86,3% still had at least one permeable by-pass. Repeat late studies after four years showed the stability of the result. Investigation into the causes of postoperative infarctions ans analysis of the results in terms of the number of by-passes carried out in relation to the number of coronary stenoses, indicate that multiple by-passes should be avoided when technical conditions are difficult, with a narrowed coronary network and of little functional value.

Adult↗
PubMed1977

[Cause of death in recent myocardial infarct. Correlation between extent of necrosis and clinical, electrocardiographic and anatomical findings].

A retrospective study of 100 case notes of patients who died from a recent myocardial infarction (less than one month before death) has established the causes of death: cardiac failure (52), rupture of the heart (40), major pulmonary emboli (3), primary irreversible ventricular fibrillation (2), unexplained death (3). Study of the extent of the necrosis by the technique of segmentation of the ventricular mass has allowed us to clarify the correlation between the "index of extent" ("i"), an the clinico-pathological findings. It has been noted in particular that those infarctions complicated by cardiogenic shock and/or by bilateral bundle branch block were those with the highest value of index of extent (i = 8.91, i = 9.40); also that cardiac failure and ventricular tachycardia were found in the extensive infarctions (i = 7,33, i = 9.52); also that rupture of the outer wall and pulmonary thromboses complicated infarctions of very small extent (i = 4,80, i = 5,67). It would not seem possible to reduce the hospital mortality of infarctions significantly, since it is essentially linked with circulatory failure caused by extensive necrosis, and with ruptures of the heart which are unpredictable and untreatable.

Arrhythmias, Cardiac↗
PubMed1976

[Is ventricular fibrillation during cardiac surgery a hasard?].

The late consequences of induced ventricular fibrillation electrically non maintained have been analysed in a series of 547 operations under extracoporeal circulation and moderate hypothermia in the adult; the length of the intraoperative period of fibrillation has been found to have no effect upon the mean postoperative left atrial pressure -- itself a sure indicator of left ventricular function. This is equally true of the variations of the factor both in the operated cases taken together, and between the various groups of operated cases. There is no evidence that ventricular fibrillation has a harmful effect when, in addition, a study is made of the postoperative myocardial complications and of the early deaths. The mean duration of ventricular fibrillation does not differ significantly statistically between the group with complications and deaths, and the group with uncomplicated operations and no mortality.

Adolescent↗