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H Mielants

Publications and source records attributed to H Mielants.

At least 163 records · Page 9Linked to original sources
PubMed1976

HLA and juvenile chronic polyarthritis.

HLA antigen have been identified in patients with juvenile chronic polyarthritis (J.C.P.) (n = 35). In J.C.P. the incidence of antigen B27 (57%) was found to be higher than in a normal population (n = 1,000). On recent evaluation of the clinical status, serology and x-rays, the patients with juvenile chronic polyarthritis who has been followed up many years, could be subdivided into four groups: Group 1: J.C.P. evolving to ankylosing spondylitis (n = 3); Group 2: J.C.P. with sacroiliitis (n = 17); Group 3: J.C.P. without sacroiliitis (n = 9); Group 4: juvenile rheumatoid arthritis characterised by a positive serology (n = 6). Groups 1 and 2 were characterized by a high incidence of antigen B27 (19/20). Only one subject of groups 3 and 4 had antigen B27. Sex distribution in groups 1 and 2 was found to be similar to that found in ankylosing spondylitis in adults and sex distribution in groups 3 and 4 was found to be similar to that found in rheumatoid arthritis in adults. It is concluded that if B27 positive develop juvenile chronic polyarthritis they have a high risk of developing sacroiliitis and acute uveitis. The authors propose to give the name Still's disease to the total group of children presenting initial symptoms corresponding to the criteria of Ansell & Bywaters (1959). Follow-up of the cases permitted their further classification as juvenile ankylosing spondylitis, as juvenile chronic polyarthritis with or without sacroiliitis or as juvenile rheumatoid arthritis.

Arthritis, Juvenile↗
PubMed1976

Rheumatoid factor and serum IgG, IgM and IgA levels in rheumatoid arthritis with vasculitis.

The authors report a significant increase in the rheumatoid factor titre in rheumatoid arthritis patients with vasculitis. A significant rise in IgG and IgA levels was found in uncomplicated RA, when compared with a normal population. The IgM levels were not found to be elevated in this group of RA patients. In the RA patients with vasculitis, on the contrary, the three Ig classes are increased when compared with the normal population, and the IgM level is increased when compared with the uncomplicated RA group. Significant relation was found between log IgM and log R.F. titre in the RA group with vasculitis. It is shown that the mild reduction of serum (by dithiothreitol 0.004 M) causes a complete negativity of the R. F. in all cases. It is concluded that the haemagglutination and the latex precipitation in vitro are induced by IgM-R. F. and not by IgG and IgA-R. F. molecules. Only free sites of IgM-R.F. play a functional role in the determination of the R. F. -titre. The authors postulated that increase in IgM in RA patients with vasculitis is partially due to the presence of free IgM-R. F. molecules in serum. Finally it is concluded that hidden IgM-R. F. molecules in patients with lower R. F. titre are not quantified by immunodiffusion methods.

Adult↗
PubMed1975

Clinical survey of and pathogenic approach to para-articular ossifications in long-term coma.

1. Thirteen patients with para-articular ossification complicating long-term coma are presented. In a series of 26 patients with long-term coma following cerebral traumatic lesions, seven cases were found with para-articular ossification. 2. The high frequency of elbow involvement is emphasized, and in all these cases posterior ossifications were present. 3. In five patients, ossifications were observed in limbs which were not paralytic and in which integrity of the efferent nerve tracts could be demonstrated. 4. The importance of functional or paralytical immobility and of a completely bedridden condition in the patients is emphasized. 5. The aetiopathogenesis of para-articular ossifications still remains unknown, but a prolonged complete immobilization possibly induces vasomotor, metabolic and trophic disorders, which can give rise to metaplasia.

Adolescent↗
PubMed1975

Avascular necrosis and its relation to lipid and purine metabolism.

Serum uric acid, triglycerides, cholesterol, and lipoprotein levels were determined in 35 patients with primary avascular necrosis of the femoral head. The results were compared with a control group and a group of gouty patients. Frequency distribution of the data in the three groups was found to be of the log normal type, and the statistical calculations were performed after log transformation of the serum values. Compared to the control group, a significant increase in the levels of triglycerides, cholesterol, pre-beta-lipoprotein, and uric acid were found in the patients with avascular necrosis. No significant difference was observed between lipid and lipoprotein levels in gout and avascular necrosis, although the serum uric acid was higher in the gouty patients. In contrast to the findings in gout, the uric acid levels did not correlate with the lipid or lipoprotein fractions in patients with avascular necrosis. There were no statistical differences between lipid, lipoprotein and uric acid levels in patients with avascular necrosis receiving corticosteroids or using alcohol, as compared with those not taking these drugs. It is concluded that avascular necrosis of bone complicating longterm use of steroids or alcohol is not induced directly by the two drugs, but that the initiating event may lie in lipid disturbances.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Is 99mTc human immunoglobulin G scintigraphy (HIG-scan) useful for the detection of spinal inflammation in ankylosing spondylitis?

OBJECTIVE: To determine the effectiveness of technetium-99m labelled polyclonal human immunoglobulin G (HIG-scan) scintigraphy to detect spinal inflammation in patients with ankylosing spondylitis. METHODS: Six ankylosing spondylitis (AS) patients with inflammatory axial pain and 3 spinal osteoarthritis (OA) patients with mechanical axial pain underwent an HMDP scan and an HIG-scan. RESULTS: In both AS and spinal OA patients complaining of axial back pain, mechanical and inflammatory axial pain, bone scintigraphy revealed foci of markedly increased tracer accumulation. An HIG-scan of the region of increased uptake on bone scintigraphy did not reveal increased tracer accumulation in either group of patients. CONCLUSION: The data suggest that the HIG-scan is not useful in detecting inflammatory spinal lesions in ankylosing spondylitis.

Adult↗