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Biomedical subjects

H Michel

Publications and source records attributed to H Michel.

At least 379 records · Page 21Linked to original sources
PubMed1975

Granulomatous hepatitis caused by B.C.G. injection during immunotherapy of a malignant melanoma.

The authors report a case of granulomatous hepatitis after treatment by B.C.G. in a patient with malignant melanoma. The patient was treated for one year by an association of chemotherapy and lyophilized B.C.G. (Pasteur Institute). Aside from the rarity of the localization the importance of this observation resides in the discovery of B.C.G. after auramine staining in the liver suggesting that the hepatic lesions were linked to the in situ presence of mycobacteria.

BCG Vaccine↗
PubMed1975

[Osteonecrosis, alcoholism and liver steatosis].

Ethylism represents at the present time one of the most frequent etiological factors of primitive osteonecrosis of the femoral head. In relation to a case of osteonecrosis of the femoral head associated with multiple bone infarcts in a chronic alcoholic, also presenting recurring jaundice, alcohol-sensitive hyperlipidaemia, and moderate anaemia, the authors review the role of fatty embolisms in the formation of primitive osteonecrosis of the femoral head. These fatty embolisms may be the result of alcohol-induced hyperlipidaemia, possibly an associated pancreatic disorders, or in particular of hepatic steatosis. A systematic histological study of 10 recent unselected cases of primitive osteonecrosis of the femoral head confirmed the extreme frequency of such embolisms (8 cases out of 10).

Adult↗
PubMed1974

Study of the role of the splanchnic organs in hepatic atrophy for the purpose of auxiliary transplantation of the liver.

Many problems must be solved before auxiliary liver transplantations can be performed successfully in animals and in humans. The most important is the atrophy of the graft. To investigate the cause of this atrophy we have done experiments with seven series of dogs. We performed organ removals (splenectomy, pancreatectomy) and shunts (splenocaval derivation, mesenterico-caval shunt, spleno-mesentericocaval shunt). Five to eight dogs were used in each series. Hepatic biochemical tests, determination of hepatic blood flow (by 198 Au, (90)Kr, Bengal Rose, Indocyanine Green) and serial liver biopsies before and after surgery (and in the long survivals) were included in the study. Results have shown a flow decrease of 32.3% +/- SD 12.0 and 20.6% +/- SD 5.2 after mesenterico and spleno-cava derivations. Histologically, a swollen cytoplasm was encountered (probably due to this important flow decrease); but we did not find any modifications of the cells (atrophy) nor of their fat and glycogen contents. On the other hand, after pancreatectomy (flow decrease of 14.2% +/- SD 7.6) we found liver cord atrophy, bile retention, important fatty degeneration and disappearance of glycogen. All of these modifications were avoided by giving insulin subcutaneously after pancreatectomy. These results suggest that graft atrophy after auxiliary liver transplantation is due in part to an insufficient supply of insulin.

Animals↗
PubMed1972

Persistent ductus venosus without portal hypertension in a young alcoholic man.

The discovery of a large patent ductus venosus resulted from radiological investigations in a 34-year-old man, a chronic alcoholic of low mental status. Splenoportal and inferior caval venograms were performed because of recent exacerbation of the neurological symptoms and electroencephalographic criteria of portacaval encephalopathy. Portal pressure was 8 mm Hg. A liver scan, a laparoscopy, and a liver biopsy were performed. They showed that the gland was atrophic with a microscopic appearance of alcoholic fibrosis, but without any nodular regeneration. The relationship between the fistula, the mental state, and the atrophic liver is discussed. Such a malformation appears to be very uncommon.

Adult↗