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Biomedical subjects

H Meyer

Publications and source records attributed to H Meyer.

At least 451 records · Page 25Linked to original sources

[Intraluminal hypertension as a pathogenetic factor of acute pancreatitis in the rat (author's transl)].

By the use of various experimental procedures with rats, the significance of intraluminal hypertension, caused by ductal obstruction, reflux of bile and duodenal reflux were considered with regard to their capacity for producing pancreatitis. The extent of the histological changes in the pancreas after 48 hours as well as the period of survival in the individual experimental groups served as the parameters for the comparison. The results show that the rise in intraluminal pressure is alone enough to produce acute pancreatitis. It follows from this that rise of pressure in the duct system caused by ductal obstruction may be the triggering factor in the induction of pancreatitis. Reflux of bile, bacterial colonisation of the pancreas by duodenal reflux as well as activation of proteolytic enzymes were not necessary a prior factors but ones which have an aggravating effect in the development of the disease.

Acute Disease↗

Atopic allergy, serum IgE and RAST specific IgE antibodies in patients with cystic fibrosis.

The occurrence of allergic diseases is studied in a group of 56 Swiss children suffering from cystic fibrosis (CF). 27% of CF children showed allergic manifestations, and 61% of CF children had positive family history for atopic diseases. The occurrence of allergies is increased in homozygotes as well as in heterozygotes for CF. Total serum IgE values are clearly increased in atopic CF children, but also slightly elevated in CF patients without allergic manifestations. Occurrence of specific IgE (RAST) for the house dust-mite Dermatophagoides pteronyssinus, timothy grass pollen. Aspergillus fumigatus and Penicillium is summarized.

Adolescent↗

[Endocrine pancreas function in cattle. I. Age-dependent responses in cattle as well as correlations between the mother animal and the fetus or the newborn].

An account of relevant literature is followed by reference to studies undertaken into age dependence of insulin levels in the blood and into the function of the endocrine pancreas in the peripartum period. The mean plasma insulin concentrations recorded from 251 heads of cattle of different age groups varies between 0.90 ng/ml and 1.90 ng/ml, and they did not exhibit any age-dependent alteration. A positively significant correlation coefficient between insulin and glucose levels in the blood was calculated for calves, aged three days and more. No significant correlations were found to exist between those two parameters in younger animals and in adult cattle. Parturition proper was accompanied by rise in insulin in the blood of mother animals. No difference between blood insulin of mother animals and blood insulin of their own newborn calves was observed up to twelve hours from parturition. Diaplacental insulin passage was established for cattle.

Aging↗

[Influence of surgery and hemodilution on the colloid osmotic pressure].

Colloid osmotic pressure was measured pre- and postoperatively in 75 patients. It could be demonstrated that the level of the colloid osmotic pressure inaccurately corresponded to the serum protein concentration. This fact can be neglected in those patients that are infused for short-term periods. However, many patients receive large amounts of colloids during long-term parenteral nutrition and in those cases an abnormal increase of plasma volume has to be expected. This might be harmful to the cardiopulmonary function and can be avoided by infusing colloids according to the level of the colloid osmotic pressure.

Adult↗

[Results of oral application of Salmonella dublin live vaccine to calves].

Orally administered streptomycin-dependent (smd) Salmonella (S.) dublin live vaccine usually is extremely well tolerated by calf under practice conditions, although other stresses may develop with high intensity (coli infection, pneumonia, S. dublin wild strain infection). Effective oral immunisation against salmonellosis of calf has proved possible in practice, but action clearly depended on dosage, as it did in clinical testing. The formula for effective oral immunisation via drinking milk is 5 . 10(10) to 1 . 10(11) smd germs daily over ten consecutive days. Satisfactory effectiveness of the oral vaccine was established by decline in clinical salmonellosis cases as well as in salmonella-caused calf loss and by bacteriological tests for S. dublin of faecal samples, histological specimens, and material received from emergency slaughter. Particular reference must be made to significant reduction in the number of immunised animals which continued to excrete Salmonellae in their faeces.

Administration, Oral↗

[Studies of carbohydrate absorption in clinically healthy and diarrheal calves].

Reported in this paper are results obtained from functional and morphological studies into absorption of carbohydrates by clinically intact and diarrhea calves. In that context, the xylose-stress test was used for functional determination of enteral absorption. Diarrhoea, caused in the calves by several pathogens, such as rotavirus, Escherichia coli, and Salmonella dublin, led to significant impairment of carbohydrate absorption in the gastro-intestinal canal. However, glucose absorption was not even fully stopped by lasting severe diarrhoea over several days. Glucose-containing special diet drinks, therefore, may help, at least partially, stabilising the glucose metabolism of calves treated for diarrhoea. A comparison between functional and morphological tests for enteral absorption seemed to suggest that histological findings should not be overestimated regarding information obtainable from them on impaired functionality of intestinal mucosa.

Animals↗

Lipid biosynthesis in the marine flatworm Convoluta roscoffensis and its algal symbiont Platymonas convoluta.

As a part of an investigations on the lipid metabolism in Platyhelminthes, the acoel Convoluta roscoffensis, which harbors the green alga Platymonas convoluta as a symbiont, was studied. Isotopic tracer experiments established that the acoel lacks the ability to synthesize de novo long-chain saturated and unsaturated fatty acids and depends on its algal symbiont for these compounds. The acoel's fatty acid composition closely resembles that of the alga but differs from those of other animals; the acoel's polyunsaturated fatty acids are of the plant type (omega 3 family) rather than of the animal type (omega 6 family). The acoel also lacks the ability to synthesize sterols de novo. It contains 24-methylenecholesterol synthesized by the algae and, in addition, significant amounts of cholesterol, which is probably a host modification product of the algal sterol. With fatty acids provided by the symbiont, the acoel has the ability to synthesize its own complex lipids. The acoel contains relatively large amounts of triglyceride, phosphatidylcholine, and ethanolamine plasmalogen. These compounds are either not present at all or present only in minute amounts in the symbiotic alga. Since acoels belong to the most primitive forms of the present-day flatworms, the observed metabolic defects in this organism suggest that mechanisms for the biosynthesis of fatty acids and sterols were lost early during the evolution of the Platyhelminthes, and that this phenomenon is widespread within the phylum.

Aging↗