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Biomedical subjects

H Mensing

Publications and source records attributed to H Mensing.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare].

Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p.o. daily. Six patients in each group (60%) responded to this regimen, and three of the responders in each group achieved complete remission of the dermatosis. In eight patients (40%) no improvement at all was observed. All the patients treated had reddening of the skin, but this was reversible after the end of therapy, as were the other side-effects, i.e. diarrhoea and dryness of the skin, which were not experienced by all patients.

Administration, Oral↗
PubMed1988

[Diagnosis of urethritis in general practice. Methods and possibilities].

The diagnosis of sexually transmitted diseases can be exactly defined nowadays, since the specific germs responsible for urethritis have been microbiologically characterized. The term "unspecific urethritis", therefore, should be replaced or completed by the identified specific germ. A short description is given of the various techniques (native procedures, staining, culture, and technical methods like Elisa or immunofluorescence), which can be performed in dermatologic practises. In addition, a survey of the urethritis germs isolated at the Hamburg Department of Dermatology is presented.

Bacteriological Techniques↗
PubMed1988

[Osteosis cutis multiplex, an organoid nevus?].

We report on a 71-year-old woman suffering from histologically proved osteosis cutis multiplex (Arzt's disease). The differential diagnosis includes multiple milia, closed comedones and hidradenomas. We discuss various etiopathologic concepts and a nevogenic origin in particular.

Aged↗
PubMed1988

[Linear circumscribed scleroderma--case report. Classification and differentiation of circumscribed scleroderma].

In linear scleroderma, a rare form of circumscribed scleroderma, the lesions are arranged in a band-shaped linear distribution and both the superficial and the deeper layers of the skin are attached to the underlying structures. This disease must principally be differentiated from eosinophilic fasciitis (Shulman's syndrome). On the basis of the clinical and laboratory data, systemic scleroderma can be excluded in nearly all the cases. Nevertheless, patients with linear scleroderma might develop systemic scleroderma or other systemic diseases of the connective tissue even after years. As a consequence, thorough physical examination as well as laboratory evaluation is necessary over a long follow-up period. We introduce a new classification of circumscribed scleroderma.

Adult↗
PubMed1988

[Etretinate therapy in solitary keratoacanthomas].

In an open clinical trial, 5 patients suffering from solitary centrofacial keratoacanthoma were treated with etretinate. The dosage was 1,5 mg/kg body-weight. All patients showed complete healing after 4-5 weeks of therapy. There were no recurrences within 3 months after therapy.

Administration, Oral↗
PubMed1988

Decline of fibroblast chemotaxis with age of donor and cell passage number.

Human dermal fibroblasts have a limited life span in culture, which is manifested by a progressive decline of their proliferative activity. Here we show by the Boyden Chamber assay that the chemotactic response of human fibroblasts to fibroblast-conditioned medium and fibronectin declines during cellular aging in vitro and in vivo. The chemotactic response of human embryonic fibroblasts (HEF) declined progressively after the 25th passage. Virtually no chemotactic activity could be observed after the 40th passage in culture. Fibroblasts cultures from donors aged between 70-90 years had lost chemotactic activity by the 15th passage. Cells from patients suffering from progeroid syndromes of premature aging showed, even in early passages, a very low chemotactic response (20% of the HEF) and lost their chemotactic activity after a few subcultures. The response to the chemoattractant fibronectin also decreased with aging. Immunofluorescence studies indicated that the decline in chemotactic activity was accompanied by the formation of a thicker fibronectin network in the extracellular matrix of senescent human fibroblasts and progeroid cells than that observed in early passage embryonic cultures. Since fibroblast chemotaxis and synthesis of connective tissue components probably play an important role in tissue repair, our results could contribute to an understanding of age-related differences in the healing of skin wounds.

Aged↗
PubMed1988

Clofazimine in dermatitis ulcerosa (pyoderma gangrenosum). Open clinical trial.

Five patients suffering from dermatitis ulcerosa (a variant of pyoderma gangrenosum) were treated with clofazimine in a daily dosage of 200 mg orally. Complete healing was noted in 2 patients, partial response in 2, no effect in 1. Side effects were mild and transitory in form of a red coloring of the skin (all patients) and mild ichthyosis (2 patients).

Adult↗
PubMed1988

Are nailfold capillary changes indicators of organ involvement in progressive systemic sclerosis?

Nailfold capillary abnormalities in 40 patients suffering from progressive systemic sclerosis (scleroderma; PSS) were studied by widefield nailfold capillary microscopy. Capillary enlargement and loss were graded using the rating scales of Maricq and Minkin. Capillary changes were correlated with organ involvement and immunological abnormalities. A high correlation was found between the grade of nailfold capillary changes and the clinical severity of PSS. Nailfold capillary microscopy seems to be a useful method to get quick information in order to predict organ involvement in PSS.

Adult↗
PubMed1988

[Neck appendages--branchiogenic surplus malformations (choristoma)].

Congenital cartilaginous rests of the neck are branchiogenic surplus malformations that are very rare. They arise from epithelial growth in a false place and frequently contain elastic cartilage. Congenital cartilaginous rests of the neck are only rarely associated with other congenital malformations.

Adult↗
PubMed1987

[Estrogen-induced gynecomastia following use of estrogen-containing local agents].

Loss of libido, decreased hair growth and gynecomastia developed in a 61-year-old man after six months of applying an estrogen-containing hair tincture for diffuse alopecia areata of the head hair. All these signs disappeared within four weeks of stopping the application, and hormone levels were again normal. Locally applied estrogen preparations are in general contraindicated in males because of their potential systemic effects. If they have to be given, hormone levels (testosterone; estradiol) must be checked.

Alopecia↗
PubMed1987

[Nuclear antibodies as serologic markers in progressive systemic scleroderma].

In all, 36 patients with progressive systemic sclerosis (29 women, 7 men) were studied clinically and immunologically; 15 patients had acrosclerosis (type I) and 21, sclerosis extending beyond the wrist (type II). The sera of all patients were evaluated for ANA (HEp-2-cells), Scl-70, centromere and other ENA antibodies. The centromere antigen was characterized by immunoblotting. All patients had high-titer ANA antibodies (100%); 36% of patients had the Scl-70 antibody (a marker antibody for PSS); and in 22% of our patients a centromere antibody was detected. In all cases the anti-centromere sera reacted with a 19.5-kd polypeptide and in 2 cases they reacted with 23- and 25.5-kd proteins in addition. In patients with centromere antibodies there was increased organ involvement (heart, lung, kidney) compared with patients who had anti-Scl-70 or other nuclear antibodies.

Antibodies, Antinuclear↗
PubMed1987

[Leukocytoclastic vasculitis].

Leukocytoclastic vasculitis is one of the more frequent syndromes of the spectrum of vasculitis. It represents a heterogeneous group of diseases, characterized by the cutaneous phenomenons of palpable purpura and persistent urtica, and the histologic patterns of vessel wall necrosis, leukocytoclasia, and hemorrhage. Pathogenetic and clinical aspects, just as therapeutic approaches are discussed in this report.

Humans↗
PubMed1987

[Capillary microscopy in connective tissue diseases].

Based on the results of a capillary microscope study on 43 patients with connective tissue disorders, the characteristic morphological abnormalities observed in the capillaries of the nail fold are presented. A high correlation was found between the pattern of changes in the capillaries and the individual connective tissue diseases. The diagnostic and prognostic usefulness of this easily performed in vivo technique is discussed in particular with regard to patients with Raynaud's phenomenon.

Capillaries↗
PubMed1986

[Jadassohn type anetoderma--case report].

A 19-year-old patient suffering from Jadassohn's anetoderma with progressive dermatrophia showed positive reaction to treatment with chloroquin diphosphate.

Actin Cytoskeleton↗