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Biomedical subjects

H Mena

Publications and source records attributed to H Mena.

44 records · Page 3Linked to original sources
PubMed1977

Treatment of ankylosing spondylitis with flurbiprofen and indomethacin.

In a parallel, double-blind and randomized trial of 6-weeks' duration, flurbiprofen (150 mg to 200 mg daily) was compared with indomethacin (75 mg to 100 mg daily) in the management of 26 patients with active ankylosing spondylitis. None of the patients in either group withdrew from the study because of lack of efficacy of the drugs. Both drugs were equally effective in the relief of pain and tenderness of the affected joints. Overall subjective improvement, assessed by the patient and the investigator at the end of the trial, was present in 90% of the patients in the flurbiprofen group and in 75% of those in the indomethacin group. The mean values of all the spinal motion tests improved in the flurbiprofen group but not in the indomethacin group. Statistically significant improvement in the Schober test was achieved in the flurbiprofen group and in chest expansion in the indomethacin group. Characteristic untoward effects related to the central nervous system and gastro-intestinal tract were present in a few patients in both groups.

Clinical Trials as Topic↗
PubMedDate not supplied

Pineal parenchymal tumors: CT and MR features.

OBJECTIVE: Our goal was to characterize the CT, MR, and pathologic features of pineal parenchymal tumors (PPTs). MATERIALS AND METHODS: We retrospectively reviewed 19 cases of resected PPTs with pathologic confirmation [10 pineocytomas (PCs), 1 mixed pineocytoma-pineoblastoma (PC-PB), and 8 pineoblastomas (PBs)], noting clinical, CT, and MRI features. RESULTS: Six male and four female patients presented with PC, one female patient with mixed PC-PB, and seven female and one male patient with PB. The CT imaging revealed 6 of 10 round and 6 of 10 small- to medium-sized masses; 7 of 9 were homogeneous, 1 of which appeared cystic. The mixed PC-PB was round and homogeneous. Eight precontrast CT scans of PCs and the PC-PB demonstrated calcifications, either peripheral (four of eight) or central (four of eight, including the mixed tumor). Pineocytomas were hypodense (five of seven) tumors, with heterogeneous postcontrast enhancement (five of seven). Most PBs (six of eight) were lobulated, and five of eight were homogeneous. Four of eight PBs imaged with CT were noncalcified hyperdense masses, which enhanced homogeneously. Pineocytomas and the PC-PB had variable signal intensity on MRI. Most PBs were hypo- to isointense on T1-weighted images, and six of six enhanced heterogeneously postgadolinium. CONCLUSION: Pineocytomas are predominantly smaller, round, hypodense, homogeneous masses with calcifications, particularly peripheral. They enhance heterogeneously on CT and present with a lesser degree of hydrocephalus in older patients. Pineoblastomas, on the other hand, are larger, lobulated, homogeneous tumors, are infrequently calcified, and present with a greater degree of hydrocephalus, often in young females. They tend to be hyperdense on CT and hypo- to isointense on T1-weighted images and enhance homogeneously on CT and heterogeneously on MRI.

Adult↗
PubMedDate not supplied

Alpha-internexin expression in medulloblastomas and atypical teratoid-rhabdoid tumors.

OBJECTIVE: To determine whether medulloblastomas and atypical teratoid/rhabdoid tumors express alpha-internexin, an intermediate filament protein that is expressed in normal neurons undergoing maturation and differentiation. MATERIALS AND METHODS: 28 medulloblastomas and 5 atypical teratoid/rhabdoid tumors were examined for the immunohistochemical expression of alpha-internexin, as well as the neuronal markers peripherin and synaptophysin, and glial fibrillary acidic protein. RESULTS: Overall, 21 of 28 medulloblastomas (75%) expressed alpha-internexin. More specifically, alpha-internexin expression was observed in 6 of 10 (60%) classic medulloblastomas, 12 of 14 (86%) desmoplastic medulloblastomas, 2 of 3 (67%) nodular medulloblastomas, and in one medullomyoblastoma. Similarly, 4 of 5 (80%) atypical teratoid/rhabdoid tumors expressed alpha-internexin. The extent of staining for alpha-internexin tended to be less than that of synaptophysin for both medulloblastomas (75% vs 93%) and atypical teratoid/rhabdoid tumors (80% vs 100%). In contrast to alpha-internexin, peripherin was expressed in only 4 medulloblastomas and one atypical teratoid/rhabdoid tumor. CONCLUSIONS: Alpha-internexin is expressed in the majority of medulloblastomas and atypical teratoid/rhabdoid tumors, indicating that these primitive tumors usually exhibit neuronal differentiation.

Adolescent↗
PubMedDate not supplied

Relationship between radiation injury and Alzheimer-related neurodegenerative changes.

The relationship between radiation injury and other neurodegenerative changes such as the formation of neuritic or diffuse plaques and tangles have received little attention in the literature. In the current study, archival tissue was examined from 485 patients with the diagnosis of either a primary or metastatic brain tumor, who had received radiation therapy between the initial and subsequent pathological study (either surgical or autopsy). Of those cases, 20 were identified that also contained cerebral cortex in both specimens. Sections were stained with the modified Bielschowsky technique and immunohistochemical preparations for beta-amyloid. Contrary to previous reports, the present study did not identify neurodegenerative changes typical of Alzheimer's disease as a consequence of radiation therapy.

Adult↗
PubMedDate not supplied

Cytologic findings in primary malignant carcinoid tumor of the cervix. Including immunohistochemistry and electron microscopy performed on cervical smears.

The cytologic findings in a primary malignant carcinoid tumor of the cervix are presented. In addition to the presence in the smears of cells suggestive of squamous carcinoma and adenocarcinoma, which led to an initial diagnosis of adenosquamous carcinoma, there were multinucleated giant cells with prominent, reddish nucleoli, finely granular chromatin and grayish-blue to eosinophilic cytoplasm, as well as smaller pleomorphic cells, against a tumor-diathesis type of background. Immunocytochemistry performed on the cervical smears showed the presence of serotonin, and ultrastructural analysis revealed abundant intracytoplasmic, membrane-bound granules in malignant cells, thus confirming the diagnosis of a carcinoid tumor.

Carcinoid Tumor↗
PubMedDate not supplied

Mesenchymal chondrosarcoma of the cauda equina.

Primary central nervous system mesenchymal chondrosarcomas are extremely rare tumors composed of primitive mesenchymal cells punctuated by islands of cartilage in various stages of differentiation. Although there are isolated reports of tumors arising in the spinal dura, to our knowledge extraskeletal mesenchymal chondrosarcoma localized to the cauda equina has not been reported in the literature. We present an unusual case of a mesenchymal chondrosarcoma involving the nerve roots of the cauda equina. The clinical, pathological and neuroimaging features are reviewed and discussed.

Adult↗