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Biomedical subjects

H Melsom

Publications and source records attributed to H Melsom.

At least 55 records · Page 3Linked to original sources
PubMed1987

Changing aspects in the treatment of squamous cell carcinoma of the oral tongue.

Two groups of patients were compared. In group 1, consisting of 304 patients treated from 1958 to 1972 (minimum observation time of 5 years), the local and regional control rate was 35 per cent. In group 2, consisting of 126 patients treated 1978 to 1983 (median observation time of 58 months), the local and regional control rate was 60 per cent (p less than 0.0001). The local and regional control rates were improved for all stages, but the differences were significant only for stages T1N0, T2N0, T3N0 and TXN2,3. The actuarial survival rates also showed improvement in group 2 patients. The incidence of treatment failure, with regard to the neck alone or tongue and neck combined, decreased from 51 per cent to 27 per cent with the newer techniques. The greatest improvement was observed in patients with T1N0 and T2N0 tumors. There was also a decrease in the failure rates in patients with the more advanced tumors.

Adult↗
PubMed1984

The great majority of childhood lymphoblastic leukaemias are identified by monoclonal antibodies as neoplasias of the B-cell progenitor compartment.

36 acute leukaemias in children, 24 lymphoblastic and 14 myelogenous, have been examined with a set of 10 monoclonal antibodies by indirect fluorescent staining. In the lymphoblastic group the leukaemic cells of 4 children were found to have T-cell phenotype, while 19 of the other 20 T-cell phenotype negative cases were found to be positive for the c-ALL antigen. All 20 were negative for surface immunoglobulin as well as cytoplasmic mu-heavy chains. However, 17 (85%) reacted positively with the monoclonal antibody AB-1 which we have developed against a B-cell lymphoma, thus revealing B-lineage specificity. Another B-lineage-associated antibody (AB-2) reacted with 8/20 (40%) of the cases with distribution similar to B-1. These findings suggest that the great majority of non-T-non-B acute lymphoblastic leukaemias are neoplasms derived from the B-cell progenitor compartment. Moreover, monoclonal antibody testing allows further sub-categorization in this group. Similarly the acute-myelogenous leukaemia group could be subdivided into phenotypic subsets. The importance of using panels of monoclonal antibodies in the diagnosis of acute leukaemias is discussed.

Adolescent↗