Search PubMed⌕ Search

Biomedical subjects

H Meier

Publications and source records attributed to H Meier.

At least 91 records · Page 5Linked to original sources
PubMed1979

[Continuously measuring procedures for the determination of alpha-amylase in serum. Comparison with amyloklastic and chromolytic methods (author's transl)].

Alpha-amylase has been measured in 57 patients' sera with normal to highly elevated amylase activities. The results obtained with four enzymatic-kinetic test-kits have been compared with those from five conventional marketed procedures. The results are evaluated by regression analysis. The specificity of the methods was analysed with amylase samples from human pancreas, human saliva and pig pancreas. The susceptibility of the kinetic procedures to interferences is smaller. The problems of conversion of activity units and reference ranges are discussed. The UltraZyme and the Monamyl neu-methods have been found superior to the other procedures because of their good practicability, precision and broad linear range; their specificity for diagnostic purposes in pancreatic diseases is less favourable compared with that of conventional procedures.

Amylases↗
PubMed1978

Relationship between Moloney MSV tumor resistance and endogenous virogene expression in AKR mouse strain and its hybrids.

We have examined the induction of Moloney-MSV tumors in AKR and other mouse strains in relation to endogenous virus expression. All virus-free strains so far tested were tumor-susceptible, while AKR was resistant. The selectivity of MSV tumor resistance, characteristic of AKR mice, was associated with AKR virogens segregation in first backcross to MuLV-negative/MSV-susceptible mice, and in a few second backcross families. Stronger evidence that AKR ecotropic virogene expression is the major, but not the sole, determinant of M-MSV tumor resistance in AKR mice was obtained in strains partially congeneic for akv-2 viral gene and in recombinant inbred lines derived from an original cross between AKR and C57L mice. These mice or lines, in which inheritance of endogenous viral genes had occurred, at the same time inherited the ability to show strong resistance to tumor induction by an exogenous oncogenic virus. This finding suggests that ecotropic endogenous viruses can exert a beneficial effect in their hosts providing some protective functions. Although the association between AKR-MuLV and M-MSV resistance is definite, the mechanisms by which MuLV+ mice are refractory to M-MSV tumors have still to be elucidated.

Animals↗
PubMed1978

Intraoperative endoscopy in oesophageal atresia and anorectal anomalies.

In four children with oesophageal atresia and two children with high anorectal anomalies a magnetic bougienage respectively a magnetic pull-through procedure have been performed. In all cases the cylinders have been placed under endoscopic control. The endoscopic intraoperative procedure has proved to be very useful in these 6 cases. Having performed a successful bougienage the cylinder of the upper segment can pass distal to the thread in the stomach and can then be grasped with a flexible endoscope via gastrostomy. Endoscopy after magnetic pull-through procedure in anorectal anomalies is necessary in order to control the newly created pathway together with manometry and x-ray studies.

Anal Canal↗
PubMed1978

Induction of type C RNA virus from cultured rabbit lymphosarcoma cells.

Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies with other mammalian type C oncornaviruses but appear to also possess unique antigenic determinants. Normal rabbit liver contained DNA homologous to a 3H-labeled complementary DNA transcript of the rabbit viral genome, indicating that type C viral genetic information is present in at least the WH/J strain of rabbits.

Animals↗
PubMed1978

[Social class and mental disorders (an empirical study in Zurich canton)].

The correlation of social class and diagnosis, therapy, mode of admission, frequency of hospitalization was tested in a population of 2103 inpatients of the two governmental and of two private mental hospitals of the Canton Zurich. The results fit to the correlations expected from the literature. The therapeutic procedures as far as reported in the case histories are mainly determined by the hospital type, not so clearly by the subject's social class. High educational status and psychotherapy are correlated. The correlation between social class and therapy is resulting of the class specific admission to one of the two hospital types. There was no sign that within one hospital patients of lower social class were placed at a disadvantage in regard to therapeutic procedures.

Educational Status↗
PubMed1977

[Traffic accidents in childhood--an analysis of 4100 cases (author's transl)].

Every hour a child dies as a result of an accident. Most accidents to children occur between 10.00 and 12.00 in the morning and between 15.00 and 17.00 in the afternoon. 2-6 year-old children are particularly liable to accidents. They make up 50% of all accidents to children. 20% of all accidents occur in traffic; in this group especially, the most deaths and multiple injuries are to be seen. An inquiry among 1000 children revealed that their knowledge of traffic behavior is particularly poor; according to the school standards of assessment, one third of all children would not reach the level of the class in this special field. 52% of all children in cars and 36% of all children on bicycles are in danger of their lives.

Accidents, Traffic↗
PubMed1977

[Funnel chest deformities: operative treatment (author's transl)].

The frequency of chest deformities is 1:100; operative treatment, however, is necessary in only 1:1000 patients with such a deformity. The most frequent deformity--in 91%--is the funnel chest. Chicken breast, combined types, and fissures of the sternum are seldom seen. Indications for operative treatment are: deformity of more than 25% of the normal sagittal diameter of the chest; heart failure and the degree of pathologic signs on the EKG; alterations of the vertebral column; psychologic aspects. Our operative procedure consists of double cartilage incision and stabilization of the chest with a metal strut.

Adolescent↗
PubMed1977

[Some methodical problems in the determination of the true amino acid digestibility in swine].

Five castrated males bridge-fistulated at the end of the small intestine and fed a wheat-casein ration were used to study the influence of the microflora in the determination of the true amino acid digestibility applying the fecal analysis method. The experimental results allow to conclude that the influence of the microflora may be regarded as a very small one if certain parameters are taken into account in applying the fecal analysis methods.

Amino Acids↗
PubMed1977

Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.

Animals↗
PubMed1977

Antitumor effects of RNA isolated from murine tumors and embryos.

We describe the antitumor effects of a certain RNA(s) isolated from murine tumors and embryos. A single i.v. injected of 10 to 30 microgram of this RNA(s) induces necrosis, hemorrhages, and regression of solid tumors in the strain of origin; in pregnant mice it is embryotoxic, causing resorption of the embryos, but has no toxic effect upon the tumor-bearing or pregnant host. Its action is highly specific, and its presence in both tumors and embryos suggests that it may result from reexpression of embryonic genes in tumor cells.

Adenocarcinoma↗
PubMed1977

Cause of funnel chest recurrences---operative treatment and long-term results.

We found that 2-3 years after operation the result is final. If a partial or total recurrence develops, this will take place within the first 2 to 3 years after operation. Local deformities of the cut ribs or the cartilages will enlarge and bulge the skin during the first 24 months. There is no overgrowth after that time. There is no reason to leave the metal strut in place longer than 1 year. All the cut and resutured ribs have grown together after that time, and there is no interference with the growth of the ribs or the further development of the chest wall. Our recurrences are due to local infections, removing the metal strut too early, i.e. within the first 4 to 5 months after operation, using a metal strut too small, and not resuturing the cut ribs themselves.

Child↗
PubMed1977

[Current status in the diagnosis and therapy of meconium ileus].

Meconium ileus is in most cases difficult to diagnose preoperatively; however, aganglionosis should be excluded in every case (rectal double-suction biopsy, manometry). In cases of uncomplicated meconium ileus (no perforation, no further intestinal obstructions) lysis of the meconium by a Gastrografin enema is tried first. In case of no relief, an intraoperative puncture of the bowel and Gastrografin instillation is performed. If there is no relief a small bowel resection is performed and a Bishop-Koop anastomosis or a chimney anastomosis established. A distinction must be made between meconium ileus, meconium disease, meconium plug syndrome, and curd obstruction. Results show a survival rate of 80%.

Humans↗
PubMed1976

Genotype dependence of monoamine oxidase in inbred strains of mice.

MAO activity was found to be influenced by the genotype or strain of mouse up to 20 days of age. The strain differences observed may derive from different rates of brain development. A number of neurological mutations comprizing three pathological classes had no effect on MAO.

Age Factors↗