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Biomedical subjects

H Meffert

Publications and source records attributed to H Meffert.

At least 73 records · Page 4Linked to original sources
PubMed1985

The influence of haematoporphyrin derivative and visible light on murine skin graft survival, epidermal Langerhans cells and stimulation of the allogeneic mixed leucocyte reaction.

The influence of combined photochemical treatment with a haematoporphyrin derivative and visible light on antigen-presenting cells was evaluated. Treatment of murine skin grafts with this procedure prolonged their subsequent survival on allogeneic recipients. The haematoporphyrin derivative and light decreased the ATPase activity of epidermal Langerhans cells in murine skin. When stimulator cells in a human allogeneic mixed leucocyte reaction were treated with the haematoporphyrin derivative and light, they lost their stimulatory capacity. It is proposed that the haematoporphyrin derivative and visible light interfere, on analogy with ultraviolet radiation, with the function of antigen-presenting cells.

Adenosine Triphosphatases↗
PubMed1985

Disodium cromoglycate inhibits allergic patch test reactions.

Disodium cromoglycate was applied before patch testing in patients with contact allergy to propipocaine hydrochloride, nickel and formaldehyde. The responses obtained were mitigated to a high degree when compared with similar effects due to corticoids.

Allergens↗
PubMed1984

Prolongation of the survival of skin grafts in mice by PUVA treatment.

The combined application of psoralen and UVA radiation to skin grafts induced a prolongation of the survival time of the grafts in mice. This was observed using the H-Y barrier, an allogeneic barrier without H-2 disparities, and a strong H-2 incompatible barrier. The effect is probably due to a reduction of antigen-presenting cells, or to other, unknown mechanisms.

Animals↗
PubMed1984

Prolongation of skin graft survival in mice by in vitro PUVA treatment and failure of induction of specific immunological memory by PUVA-treated grafts.

Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated with 8-methoxypsoralen and longwave ultraviolet radiation were not able to induce an immunological memory as revealed by a second transplantation of normal skin. The results show that primary and secondary skin graft rejection can be affected by the combined action of psoralen and ultraviolet radiation.

Animals↗
PubMed1984

Phototoxicity and antipsoriatic effect of a topical methoxypsoralen solution in relation to the application time.

The phototoxicity and antipsoriatic activity of a topically applied 0.075% methoxypsoralen alcohol-glycerol solution was investigated in relation to the interval between drug application and irradiation. On healthy skin, maximum UVA sensitivity for erythema development appeared 40 to 60 min after the application of the methoxypsoralen solution, but in psoriatic plaques the antipsoriatic UVA sensitization reached its maximum after 10 to 20 min. This difference between induction of antipsoriatic effect and erythema sensitivity may be explained by rapid penetration of methoxypsoralen in psoriatic lesions or by different targets at the cellular level for the erythema-producing effect and the antipsoriatic effect.

Administration, Topical↗