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Biomedical subjects

H Meffert

Publications and source records attributed to H Meffert.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Effect of a single mild infrared A hyperthermia on body temperature, heart rate, blood pressure and blood viscosity in healthy probands and patients with stage I and II arterial hypertension].

Report on mild and single whole body-irradiations with near infrared (IRA). The central body temperature went up to 38.5 degrees C in 9 healthy subjects and 9 patients known as having essential arterial hypertension of the stages I or II. In case of hypertensive patients a single exposure decreased significantly both arterial and venous blood pressure as well as the resulting mean arterial blood pressure. This beneficial effect lasted for at least 24 hours. Besides that, improvement of peripheral hemodynamics and plasma viscosity also was proven. Obviously, improved peripheral hemodynamics is linked to that blood pressure lowering effect which happens due to dilatation of peripheral blood vessels.

Adult↗
PubMed1989

[Hemodynamics of patients with essential hypertension in mild infrared hyperthermia].

Hyperthermia therapy in hypertensive patients is been discussed as an effective treatment. The aim of this study was to control the behaviour of circulation in conditions of hyperthermia. A group of 6 males, 32-53 years old, suffering from essential hypertension stage I-II underwent a single whole body-irradiation with near infrared (IRA), lasting over one hour. The body temperature rises up to maximal 38.5 degrees C. Before, during and after treatment the blood pressure (BP), the heart rate (HR), the stroke volume (SV), the cardiac output (CO) and the ejection fraction - measured by radionuclide ventriculography - where estimated and the peripheral arterial mean pressure (Pm), the ejection resistance (AW) and the Total peripheral resistance (TpW) were calculated. During irradiations there was a significant decrease of BP, AW and TpW. HR, SV, CO and EF increased significantly. Due to IRA irradiations there was a change in microcirculation with the consequence of lowering the blood pressure. The concomitant stimulation of the heart was well compensated as shown by CO, SV and EF.

Adult↗
PubMed1989

[Photodynamic therapy of psoriasis palmaris et plantaris using a topically applied hematoporphyrin derivative and visible light].

Two different hematoporphyrin derivative (HpD) containing ointments were checked for their photodynamic efficacy in 17 patients suffering from palmoplantar psoriasis. Following topical application and subsequent irradiation with visible light, in all the patients psoriatic plaques resolved either to some substantial degree or totally. That method of treatment so far is recommendable for treating psoriasis of markedly hornifyed skin regions. However, further efforts are needed to perfect therapeutical circumstances like preparation time, spectral distribution of light and galenics of HpD-containing ointment.

Adult↗
PubMed1989

[Systemic effects of ultraviolet, visible and infrared radiation in serial whole body irradiation. I. Oxygen utilization, flow properties of blood, hemodynamics, blood components and phagocytosis].

31 healthy volunteers at the age of 19 to 29 years underwent whole-body irradiations by either ultraviolet radiation (NARVA UVS 65-2; continuous sunshine-like emission, predominantly UVA plus 8% UVB; cumulative doses after 4 and 20 irradiations 8.8 J/cm2 and 51.0 J/cm2, respectively), or visible light (emission of a 3,500 Watt lamp HGMI 3500 DL, Tungsram CSSR, filtered through 6 mm window glass; cumulative dose 267.0 J/cm2 after 4 irradiations) or infrared radiation (250 Watt infrared lamps NARVA "Biotherm", emitting more than 70% infrared radiation; cumulative dose 159.0 J/cm2 after 4 irradiations). Before, during and after the irradiation series the following investigations were made: Arterial and venous oxygen pressure, oxygen utilization index; flow properties of peripheral blood (plasma viscosity, erythrocyte aggregation kinetics, apparent blood viscosity); hemodynamics (veineal plethysmography, 133Xenon clearance, functional diameter of small blood vessels, peripheral blood pressure), phagocytotic capacity of polymorphonuclear white blood cells; hematological parameters (blood sedimentation rate, polymorphonuclear and eosinophilic blood cells, red blood cells, hemoglobin, hematocrit), serum proteins (IgG, IgA, IgM, complement C3, alpha-1-glycoprotein, alpha-1-antitrypsin, haptoglobin, transferrin); calcium and phosphate in serum. As far as irradiance, dose and treatment frequencies are concerned, the experimental conditions were very similar to those in phototherapeutical practice. Under these circumstances there were no hints for unwanted early effects after application of all the three kinds of optical radiation used in that study. Considerable systemic responses exclusively were found by use of ultraviolet radiation. Under these experimental conditions according to dermatological phototherapy it has been proven the following biopositive systemic responses are due to happen: increase of serum calcium and phosphate, improvement of blood oxygen utilization, improvement of blood flow properties, and enhanced phagocytic capacity of polymorphonuclear white blood cells. Regarding the parameters taken in that study, no early unwanted side effects are to expect after therapeutical application of rather large doses of visible light or infrared radiation.

Adult↗
PubMed1989

[Willibald Gebhardt (1861-1921). His life and his achievements in photomedicine].

As far as history of sports is concerned, Dr. Willibald Gebhardt is well known as an energetic and excentric chemicist who founded and lead the first ever German Olympic Team to the games at Athens, in despite of the declared will of both Prussian government and sports functionaires. The non-physician Gebhardt achieved distinct progress in photomedicine und hygiene which was holded back or doubted by the experts during his lifetime. Gebhardt's book "Die Heilkraft des Lichtes" printed in 1898 represents a milestone of photomedicine as well as a goldmine in view of future photomedical developments.

Germany↗
PubMed1989

Influence of a transfusion of donor leukocytes treated with 8-methoxypsoralen and long-wave ultraviolet light (PUVA) on skin allograft survival in mice.

The influence of pretransplant donor spleen cell infusions on murine skin graft survival was studied. In dependence on the time interval between transplantation and transfusion an accelerated or delayed rejection of the grafts was observed. If the donor spleen cells were treated with the photosensitizer 8-methoxypsoralen and UVA light (PUVA) a graft prolongation was achieved at all time intervals. Furthermore, the survival of antigenically unrelated grafts was also prolonged. An additional immunosuppressive treatment or the recipients with antilymphocyte serum, but not cyclophosphamide, led to a further prolongation of graft survival. The survival of PUVA treated skin grafts was not longer in recipients preinfused with PUVA treated donor cells compared with untreated hosts. The results presented in this work may have implications in clinical organ transplantation to prevent sensitizing reactions by sparing protective mechanisms for the graft.

Animals↗
PubMed1989

[Anti-psoriasis and phototoxic effect of a hematoporphyrin derivative following topical administration and irradiation with visible light].

An ointment, consisting of 100 micrograms hematoporphyrin derivative +5.0 ml dimethylsulfoxide +95.0 ml Unguentum Alcoholum lanae SR, was checked for both phototoxic and antipsoriatic efficacy. After topical application and irradiation with visible light or ultraviolet radiation, healthy skin showed delayed erythemas, whereas psoriasis plaques improved markedly.

Adolescent↗
PubMed1988

[Therapeutic use of ultraviolet irradiation in medicine--scientific principles and clinical results].

Sunshine is one of mankind's oldest remedies. Merely forgotten, UV light treatment came back recently due to (1) technological progress, providing particular UV wavelengths (2) basic research, discovering mode of action at molecular level, and (3) rising knowledge about skin as the primary target. Human skin is a rather difficult organ, possessing a considerable part of the immune system, the so-called skin associated lymphoid tissue. Different biological effects are caused by UV irradiation at different wavelengths. UV radiation alone as well as together with a photosensitizer also can cause systemic effects. Dealing with these, results of basic research and their application on modern treatment of some skin diseases, transplantation medicine, non-specific resistance system, and treatment of cardiovascular diseases are discussed.

Animals↗
PubMed1986

PUVA therapy damages psoriatic and normal lymphoid cells within milliseconds.

Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or psoriatics were taken, within 1 ms mixed with 8-methoxy-psoralen (8-MOP) at concentrations of 1.0, 0.1, and 0.5 microgram/ml, and then irradiated by a 337-nm laser pulse (0.5 mJ/cm2) lasting some picoseconds. Approximately 1 ms after administration of 8-MOP to the cell surface at least 10% of the cells were damaged, as could be judged using the standard trypan blue exclusion test. This happened at 8-MOP concentrations of 1.0 or 0.1 microgram/ml plus laser irradiation, but a concentration of 0.05 microgram/ml 8-MOP plus laser exposure did not cause any effect within 8 ms after mixing. There was no difference between using lymphoid cells from healthy persons or from psoriatics. The fact that only a very short time is necessary before cell damage occurs means that, as far as the fast PUVA effect is concerned, a photochemical reaction involving nuclear DNA can be discounted.

Cell Membrane↗
PubMed1986

Inhibition of HLA-DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment.

Treatment of human peripheral blood mononuclear cells with UVB light, the photosensitizing system 8-methoxypsoralen plus UVA light (PUVA), or hematoporphyrin derivative plus visible light leads to an inhibition of their stimulatory capacity in an allogeneic mixed leukocyte reaction despite unaltered expression of HLA-DR antigens when tested immediately after irradiation. However, HLA-DR positive cells disappear among mononuclear cells in the interval between 4 and 8 h after treatment with either UVB, PUVA, hematoporphyrin derivative and light, or heating to 45 degrees C. The expression of HLA-DQ, but not HLA-A,B,C, antigens, was similarly affected by these treatments. The significance of these results is discussed.

Antibodies, Monoclonal↗