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Biomedical subjects

H Mau

Publications and source records attributed to H Mau.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Production of human monoclonal antibodies by heterohybridization of human B lymphocytes of the spleen with mouse myeloma cells].

Human lymphocytes were derived from the spleen of a 15-year-old female patient after partial splenectomy. High cell yield and percentage of human B-lymphocytes (over 30%) gave useful conditions for their fusion to mouse myeloma cells (P3 X63/Ag8/653). Fusion efficiency (cultures with growth) was 96%. From 288 initially seeded cultures 176 showed IgM and only one IgG production as determined by enzyme immunoassays. Twenty primary cell lines were cloned with differing results and 17 heterohybridoma cell clones with high IgM production rates could be established for more than 6 months in vitro. The present results show the possibility to produce human monoclonal antibodies in heterohybrids derived from human spleen lymphocytes.

Adolescent↗
PubMed1986

[Surgical correction of atypical aortic coarctation with hypertension].

Atypically localised coarctation of the aorta is one of the very rare pathological findings. Hypertension of unknown aetiology, atypical vascular sounds, and symptoms of collateral circulation are indicative for diagnosis. Vascular surgery is justified in any case by the juvenile age of the patients concerned and by poor quoad vitam prognosis. Generally, surgical intervention should be undertaken with patients between eight and 14 years of age. Surgical methods and results are reported.

Adolescent↗
PubMed1985

Scoliosis screening in West Germany and its pitfalls with Scheuermann's disease.

The problems of scoliosis screening in the Federal Republic of Germany are outlined. The main pitfall with regard to the high numbers of very mild scolioses seems to be the disregard of mild forms in connection with Scheuermann's disease, in spite of their good prognosis. This group should be clearly separated, by means of a lateral X-ray, from beginning idiopathic adolescent scoliosis, with its doubtful prognosis. Moreover, it is necessary to exclude all curves below 10 degrees shown on the a.p. standing X-ray, not forgetting the fact that a seemingly mild scoliosis might be due in part to misleading projections and positions. The use of an electronic balance scale may be helpful in this respect.

Adolescent↗
PubMed1985

[Therapy of portal hypertension in childhood].

From 1980 to 1984 fortyeight children with portal hypertension were treated, 37 out of these had a prehepatic bloc. In 19 children a sclerotherapy was performed. Seven times a bleeding recurrency occurred and an esophageal stenosis was seen in 2 cases. The distal splenorenal shunt (Warren) was performed 16 times. All children survived, one pneumonia and one slight pancreatitis were observed post-operatively. Four times a shunt obstruction was found at follow-up examinations. Bleeding recurrencies did not appear.

Child↗
PubMed1985

[Long-term prognosis of portal hypertension in childhood].

In Europe more than 70 per cent of children with portal hypertension suffer from a prehepatic block. Most of them underwent an umbilical vein catheter treatment in postnatal anamnesis. Constructing a selective distal splenorenal shunt (Warren-shunt) is a definitive therapy. This operation is possible for children having a patent splenic vein with a diameter of at least 7 mm measured by splenoportoseriography. Sclerosing of the oesophageal wall is a good palliative treatment for small children with a diameter of the splenic vein of less than 7 mm. Children with prehepatic block and patent Warren-shunt have a good prognosis.

Amino Acids↗
PubMed1985

[Diagnosis and surgical therapy of organic hyperinsulinism].

The diagnosis of an insulin producing tumour can be confirmed by a minimum of biochemical investigations. Its preoperative localisation is more difficult. Sonogram, Computertomogram, selective angiography and percutaneous transhepatic collecting of blood samples for insulin analysis from the portal system were preoperative measured to localize the tumours in 32 of 37 patients of our series. In 2 patients intraoperative tumour localisation by measurement of incorporated p32 proved to be effective. In B-cell-carinomas pancreas resection is the adequate therapy. With regard to the therapeutic effects a high risk is involved in the 'blind' left or right sited resection of non-localized tumours.

Adenoma, Islet Cell↗
PubMed1984

The significance of proprioception on postural stabilization as assessed by ischemia.

In order to further investigate the role of proprioceptive input from the legs for the maintenance of upright human posture ischemia was bilaterally applied at the level of the ankle or the thigh. Preservation of efferent innervation was ascertained by measurements of the maximal force of voluntary dorsi- and plantarflexion. Visual stabilization was excluded by eye closure. To test different frequency domains of postural stabilization, subjects were exposed to sudden ramp tilts or to sinusoidal low frequency (0.3 Hz) anteriorposterior displacements of the supporting platform. The results indicate that proprioceptive input from skin, pressure and joint receptors of the foot (ischemia at the ankle) is of minor importance for the compensation of rapid displacements, but plays a significant role when the platform moves at low frequencies. M1 and M2 responses in the stretched triceps surae and the late antagonistic response of the anterior tibial muscle (M3) are preserved with ischemia of the foot. Reversible ischemic paralysis or other (yet unidentified) mechanisms of destabilization must be responsible for the severe decrease of postural stability observed with ischemia at the level of the thigh and sinusoidal platform movements. Complete loss of the proprioceptive input from the legs leads to a pathognomonic 1Hz body tremor both under static and dynamic conditions.

Electromyography↗
PubMed1983

[Arteriosclerotic aneurysm as an unexpected intraoperative finding].

Unexpected arteriosclerotic aneurysms were found in 11 patients during operation performed for other reasons. They were located in the abdominal part of the aorta (8 cases), in the popliteal artery (2 cases) and in the cranial mesenterial artery (1 case). Complications of these aneurysms such as rupture or peripheral embolization, led to surgical intervention in 5 patients.

Aged↗
PubMed1982

[Differential diagnosis of early scoliosis in Scheuermann's disease and idiopathic scoliosis (author's transl)].

In order to avoid overtreatment or undertreatment of a beginning scoliosis early differentiation of the clinically unimportant concomitant scoliosis of Scheuermann's disease is essential as against early idiopathic scoliosis, spondyloepiphyseal dysplasia and the fixed round back deformity of adolescents. Scheuermann's scoliosis as opposed to idiopathic scoliosis is characterised by the almost complete lack of vertebral rotation (as with spondyloepiphyseal dysplasia), by a localized unilateral narrowing of the intervertebral space in the a.p. x-ray, as well as by a slight Z- or E-pattern, and a relative shortness of the curves. Simultaneous dorsal kyphosis may be absent. Indispensable is furthermore, the familiarity with the early x-ray signs of Scheuermann's disease in the lateral view as compared with the X-ray of the fixed roundback.

Adolescent↗
PubMed1982

[Compartment syndromes of the lower extremities (author's transl)].

A reduction of the arterial blood pressure of the muscles of the 4 tight fascial compartments of the shank may be initiated by: Trauma and operation of the lower extremities, spontaneous bleeding, occlusion of the arteries, general and local hypotonia due to elevation of the leg, as well as by drug abuse and increased stress of the muscles of the lower extremities. This is followed by an increased swelling and tension of the tissue with ischemia and consecutive paralyses of the nerves and muscles in the presence of almost simultaneous muscle contractures. We may encounter a double insult, a "rebound" effect, if f.i. following removal of a two thigh bandage of the shank the compartment again becomes too narrow due to a postischemic swelling. The anterior tibial syndrome is frequently caused by an increased exertion in sports and in the military service. The dorsal syndromes are often accompanied by Sudeck's dystrophy in the late stages. In treatment the early and extensive longitudinal incision of the respective fasciae is imperative in order to prevent the typical equino-varus deformity and hallux flexus.

Adult↗
PubMed1982

[Animal experimental studies of the bladder effectiveness of the anticholinergic agent Mictonorm].

Pressing need of selectively vesically or spinally acting neuropharmacons exists for patients with neurogenic disturbances of the function of the urinary bladder especially for children with myelomeningocele. The medicament MICTONORM a peripherally effective anticholinergic drug was tested in healthy young pigs with reference to the effect on the storage volume of the bladder. Cystometrograms were recorded in the narcotised experimental animal before and after intravenous application of 0.5 mg MICTONORM per kg body mass. The average increase of the vesical capacity after the drug application amounted to 39.2% (dispersion 6.3 - 95.3%). The values of the vesical pressure showed a nonuniform behaviour. An effect in the afferent part of the vesical reflex arc comes into question for the pharmacon because of the type of action.

Animals↗
PubMed1981

The changing concept of infantile scoliosis.

A description of infantile scoliosis is presented. It is thought to be provoked by persistent nursing of the infant during the first months of life in an oblique supine position. In addition deformities of the head, thorax, pelvis and contractures of the neck, hip and feet are often observed: the so-called "Seven-point syndrome". Following introduction of the prone-lying position as a prophylactic measure the incidence of infantile scoliosis has decreased considerably in Germany. The oblique positional scoliosis ("resolving") is probably a separate entity. It is not clear, however, whether it may occasionally become progressive or whether the progressive forms represent the lower end of the spectrum idiopathic adolescent, juvenile and infantile scoliosis.

Humans↗