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Biomedical subjects

H Matthys

Publications and source records attributed to H Matthys.

At least 307 records · Page 17Linked to original sources
PubMedDate not supplied

The bronchosparing effect of celiprolol, a new beta 1- alpha 2-receptor antagonist on pulmonary function of propranolol-sensitive asthmatics.

Twelve normotensive asthmatics who demonstrated bronchoconstriction after a single oral dose of 80 mg of propranolol received (according to a double-blind, randomized, crossover design) placebo, celiprolol 200 mg, and celiprolol 400 mg at intervals of at least three days. Pulmonary function parameters were measured by whole body plethysmography just before treatment and hourly for three hours. Thereafter, terbutaline (0.5 mg), a beta2 agonist, was administered in aerosol form at 15-minute intervals for a total of five doses. This design permitted a safety assessment of the effect of placebo and celiprolol on resting pulmonary function and the evaluation of any interaction between this beta blocker and terbutaline. Propranolol 80 mg produced a statistically significant decrease in a forced one second expiratory volume and forced vital capacity, and a pronounced rise in airways resistance as compared with either dose of celiprolol or with placebo (P less than .001). The effect of celiprolol was not statistically distinguishable from placebo. Terbutaline caused further net bronchodilation after administration of celiprolol and placebo but, even at supratherapeutic doses, failed to restore pulmonary function parameters to baseline levels after treatment with propranolol. The bronchosparing effect of celiprolol may be due to its unique pharmacologic profile, which includes cardioselectivity, modest beta 2-agonist activity, and alpha 2-receptor blockade.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

[Inhalation bronchial provocation tests in children: comparative measurements of oscillation, occlusion pressure and plethysmographic resistance].

Examination of the lung function and bronchial provocation tests are useful for confirmation of an airway obstruction. There is a need for measurements independent of child cooperation. The standard method is body plethysmography. Forced oscillation method and interrupted occlusion method were recently introduced. Measurements of airway resistance by body plethysmography (Raw), by forced oscillation (Ros) and by interrupted occlusion method (Rvd) were compared during 78 inhalative bronchial provocation tests. The correlation index between Raw and Ros total was 0,84 and between Raw and Rvd 0,89. There is a good sensitivity and specifity in allergen bronchial provocation testing in all three methods. A bronchial sensitivity is confirmed in body plethysmography by 100% increase of Raw. In the interrupted method a 50% increase of Rvd in children smaller than 165 cm and in forced oscillation method a relative increase of 25% (0,15 kPa/l/s) is sufficient to assess a bronchial sensitivity to tested allergen.

Adolescent↗
PubMedDate not supplied

The pathophysiological role and therapeutic implications of platelet activating factor in diseases of aging.

Platelet activating factor (PAF) is a unique phosphoglyceride which possesses many potent biological activities relevant for the pathogenesis of diseases of the elderly. PAF is generated and released by numerous cell types and tissues and is rapidly metabolised through a well defined metabolic cycle. Its biological actions are mediated via direct and indirect stimulatory effects on target cells and tissues. The current knowledge of PAF and its role in cardiovascular disease, thromboembolism, cerebral ischaemia and neurodegenerative disorders are discussed in detail. It is likely, that in future, a better understanding of the pathophysiological and physiological roles of PAF will provide new strategies for the treatment of human diseases of aging.

Aged↗
PubMedDate not supplied

The immunoperoxidase slide assay. A new method for the demonstration of surface antigens on bronchoalveolar lavage cells.

The immunoperoxidase slide assay (ISA) is described as a new method for the demonstration of surface markers on bronchoalveolar lavage (BAL) cells. This technique makes the unlabelled antibody enzyme method using the peroxidase-antiperoxidase (PAP) immune complex for labelling suitable for the evaluation of single cells. By this method, viable cells are firmly attached to poly-L-lysine coated reaction areas of siliconized glass slides. The ISA technique was found to be very useful for testing a battery of monoclonal antibodies against surface antigens on BAL cells from one specimen in parallel. This is due to the low amount of cells needed for this method. Other advantages compared to immunofluorescence techniques are the reduced costs, the possibility of a permanent documentation of the staining on the glass slide preparations, the higher sensitivity and the well preserved morphology of cells. Normal values for lymphocyte markers (OKT3/Leu-1, OKT4/Leu-3a, OKT8/Leu-2a, Leu-7, B1) and monocyte/macrophage markers (OKIa, anti-Mono, anti-IgG) are reported.

Adolescent↗