Biomedical subjects

H Maruoka

Publications and source records attributed to H Maruoka.

At least 37 records · Page 2Linked to original sources

PubMed1995

Plasma concentrations of atrial natriuretic peptide in cardioembolic stroke with atrial fibrillation.

The aim of the present study was to determine whether the level of plasma atrial natriuretic peptide (ANP), an indicator of atrial stretching, correlates with the formation of a thrombus in the left atrium during cardioembolic stroke with atrial fibrillation. Plasma concentrations of immunoreactive ANP and thrombin-antithrombin III complex (TAT) were measured in five age-matched groups including: 16 patients with acute cardioembolic stroke and atrial fibrillation (group 1), 26 patients with chronic cardioembolic stroke and atrial fibrillation (group 2), 27 patients with atrial fibrillation without previous stroke (group 3), 21 patients with acute lacunar stroke (group 4), and 27 healthy controls. The plasma ANP levels were higher in group 1, regardless of the stage, than those estimated at chronic stage in group 4 and in healthy controls. There were no stage-related differences between groups 1, 2 and 3. Plasma levels of ANP in group 2, a high risk group of cardioembolic stroke, were higher than in group 3, a low risk group. There was no correlation between plasma levels of ANP and mean blood pressure, pulse rate or plasma levels of TAT in any group. These results indicate that the determination of plasma ANP concentration is useful to distinguish a high risk patient from a low risk patient and also a cardioembolic stroke patient from a lacunar stroke patient. They also underscore the difficulties in recognizing left atrial thrombus formation by determining the plasma ANP concentration in cardioembolic stroke.

Aged↗

PubMed1995

[Clinical study of photodynamic therapy for laryngeal cancer].

Photodynamic therapy (PDT) is an innovative treatment involving the use of a photosensitizer and low powered laser to selectively destroy tumor cells. In the head and neck, its application to laryngeal papilloma, metastatic tumor and oral cancer have been reported but our report on PDT for laryngeal cancer is the only clinical report in Japan. At present, we treat laryngeal cancer by PDT using argon and excimer dye lasers such as the HpD. In the present study, we assessed the utility and safety of PDT and investigated long-term prognosis after this therapy. The subjects were 12 patients with laryngeal cancer who underwent PDT between February 1988 and October 1993. Among them, ten with cancer of the vocal cords underwent PDT as the primary treatment and two underwent PDT because of recurrence after radiotherapy. Under local anesthesia, PDT was performed using a video endoscope (Pentax EB2000). The optimal dose from an argon dye laser was set at 200-500 mW/cm2 of continuous waves for 20 minutes and that from the excimer dye laser was set at 200 J/cm2 of pulse waves (3-4 mJ/pulse, 30-40 Hz). The argon dye laser used was the Fujinon PDT developed by Fuji Photo Optical Co., Ltd. The excimer dye laser used was a product of Hamamatsu Photonics Co., Ltd. 1) Effect of PDT The effect of PDT as a primary treatment for ten patients was classified as CR in eight and PR in two cases, the CR rate being 80.0%. When evaluated only for T1 patients, the results were classified as CR in eight and PR in one. The patient whose response was classified as PR had refused repeated PDT. CR was maintained for five and 13 months in the two patients who underwent PDT as a secondary treatment after radiotherapy. CR was obtained in 83.3% of all patients studied. 2) Duration of the effect of PDT and long-term prognosis The patients were followed up for 14 to 71 months. The longest duration of CR achieved by PDT monotherapy was 65 months. Among the patients who underwent PDT as a primary treatment, one developed local recurrence and underwent radiotherapy. However, the prognosis was uneventful in all other patients. CR after PDT monotherapy was maintained for 42 months in one T3 patient. Two patients with a history of previous treatment thereafter relapsed and underwent total laryngectomy. The larynx could be conserved in 83.3% of all patients. However, it could be conserved in 100% of patients who underwent PDT as a primary treatment.(ABSTRACT TRUNCATED AT 400 WORDS)

Aged↗

PubMed1995

[Changes of type IV collagen 7S and fibronectine in a patient with isolated ACTH deficiency].

A 60-year-old man presented with waste, muscle weakness and pain of knees and shoulders. Endocrinological investigations revealed low plasma cortisol and ACTH levels, delayed response of plasma cortisol to ACTH, no response of plasma ACTH to CRF and normal response to other pituitary hormone to corresponding stimulate test. He was diagnosed as isolated ACTH deficiency. Then we examined plasma type IV collagen 7S and fibronectin, because experimentally, corticosteroid regulates the extracellular matrix structure composed of type IV collagen, fibronectin and so on. These parameters were elevated and rapidly decreased to the normal range with the replacement of hydrocortisone, simultaneously his arthralgia was improved. These parameters can reflect the biochemistric change in cortisol deficiency state.

Adrenocorticotropic Hormone↗

PubMed1995

[Catamenial pneumothorax with diaphragmatic and visceral plural endometriosis].

A 47-year-old woman was admitted to our hospital because of two episodes of right pneumothorax. After continuous suction through a thoracic drain, a computerized tomographic scan showed that air was still trapped between lung lobes. Video-assisted thoracic surgery revealed a bulla on the visceral pleural of the upper lobe (S2) and several dark-red spots and white-coated lesions surrounding a defect of the diaphragm. The involved portions of the diaphragm and of the lung were excised. Microscopic examination of the excised specimens showed endometriosis. Catamenial pneumothorax may be caused by intrathoracic endometriosis, but very few cases in which pulmonary or visceral pleural endometriosis was demonstrated histologically have been reported.

Blister↗

PubMed1994

Phagocytic ability of polymorphonuclear cells and macrophage is not decreased in aged bed ridden patients.

The phagocytic ability of polymorphonuclear cells and macrophages from aged, bed ridden patients was investigated. Phagocytosis of carbon in aged bed ridden patients did not differ from that of young controls, and extent of upregulation of granulocytes phagocytosis in response to elevation of incubation temperature was also similar between the two groups. Morphological changes of macrophages in response to ingestion of colloidal carbon was more prominent in young controls. These data suggest that a depressed phagocytosis is not an important factor in the increased susceptibility to infections of aged bed ridden patients, although the reactivity of macrophages may be more closely related to the infection defence.

Aging↗

PubMed1994

A seroepidemiological study of hepatitis C virus (HCV) in an area with a high prevalence of chronic liver disease in the Kyushu district of Japan.

The incidence of hepatitis virus type C (HCV) in an area, Futase, of Iizuka city in Chikuho province in the northeastern part of Fukuoka prefecture in Kyushu, Japan, was estimated by screening sera for anti-HCV antibodies. Titers of anti human T-lymphotropic virus type I (HTLV-I) antibodies and hepatitis virus type B surface antigens (HBs) were also determined. The area of the present study is known to have a particularly high prevalence of chronic liver diseases, because coal mining was the key industry until a few decades ago. Also, in the old days it was rather isolated from the neighboring vicinities by surrounding mountains. The subjects of the present survey were 310 patients (117 males and 193 females) with various chronic diseases who visited Futase Social Insurance Hospital during a two year period from 1991 to 1992. Anti-HCV antibodies were detected in the sera of 55 patients, which is an overall positive rate of 18% (26% in male and 14% in female patients). This is extremely high compared to an estimated nationwide average positive rate of 1.6%. Even in 270 patients with normal liver function, the incidence was as high as 10%. The incidences were particularly high in groups of patients aged 40 through 49, 50 through 59 and 60 through 69, ranging from 20 to 23%, while they were as low as 13 and 17% in those aged 70 through 79 and 80 through 89 years, respectively. A high incidence, 57% was estimated for the patients with impaired liver function due to chronic liver diseases, especially in those concomitantly having diabetes mellitus (DM), 91%. The incidence of anti-HCV antibodies was the highest, 100%, in patients having both liver cirrhosis (LC) and DM. This was followed by those having chronic hepatitis (CH) and DM concomitantly and by those with LC alone, 86% each, and by those with CH alone 44%. Furthermore, the genotypes of the HCV in the sera of nine randomly selected carrier patients who had anti-HCV antibodies, even though they had diseases other than hepatic diseases and their liver functions were normal, were examined by the polymerase chain reaction method employing type-specific primers for DNA amplification. As a result, all the HCV strains were type II. On the other hand, there were no apparent differences in the incidences of HTLV-I in the area of the present study and in neighboring provinces of the same prefecture, Fukuoka.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

PubMed1992

[Compression of the graft during the corrective surgery for scoliosis in a patient who has undergone a Rastelli's operation: a case study].

A 14 year-old male who had undergone Rastelli's operation for the tetralogy of Fallot had general anesthesia for the corrective spinal instrumentation and posterior fusion. The patient also suffered from the complication of Klippel-Feil syndrome. During the operation, right ventricular pressure gradually increased from 34 mmHg to 60 mmHg and systolic blood pressure decreased from 110 mg to 80 mmHg when the maneuver to correct spinal deformity was done. The hemodynamics returned to its former level after the maneuver was resumed. This change was presumably attributed to the fact that the external conduit was compressed by the sternum and vertebral bodies. In order to prevent this hazardous incidence, it is crucial to understand both the three-dimensional configuration of the thoracic structure and the influence of spinal correction on it. In the prone positioned patients with scoliosis, especially lordoscoliosis, compression or dysfunction of the artificial valve might occur and we have to be aware of the possibility of the compression during general anesthesia and after corrective surgery.

Adolescent↗

PubMed1982