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Biomedical subjects

H Martin

Publications and source records attributed to H Martin.

At least 343 records · Page 19Linked to original sources
PubMed1979

[The molecular biology of aging -- 15: Structure and function of the genetic apparatus in aging. II. Synthesis and metabolism of RNA].

With aging in different organs there are similar or tissue specific changes of the ribonucleic acids in respect of the quantity, the spectrum of different RNA species and the metabolism of RNA. Among these processes the template function of the chromatin and the behaviour of the RNA polymerases are important influencing factors. In aging the sensitivity of the RNA synthesis against hormonal stimulation is decreased in the most cases. A survey about the results of many in vivo and in vitro experiments of the literature is given. The opinion is advocated that the problems of the gene regulation and gene expression are a important field of work in the experimental gerontology.

Adrenal Cortex Hormones↗
PubMed1979

[The molecular biology of aging -- 14: Structure and function of the genetic apparatus in aging. I. Changes in the genome].

In the last years there is agreement over the fact that genetic properties have an essential influence on the ageing process. Therefore many scientists choose the genom and its properties as object of the gerontological investigation. This review shows that changes are possible on all of structure levels of the genom down to the lowest molecular stage with increasing age. This concerns as well postmitotic as intermitotic, proliferating cells and tissues, too. Actually repair processes of defective DNA find an increasing consideration. Until now it is not possible to establish if the observed changes are the cause or the result of ageing processes.

Aging↗
PubMed1979

[Cerebromeningeal fibroxanthoma. A case report].

This is a report on an almost seven-year-old girl with a histologically evident fibroxanthoma of the leptomeninx and dura mater cerebri. To the authors' knowledge, this is the fifth case of an intracranial fibroxanthoma reported in the literature. Histologically, the tumor consists of close-lying pleomorphic cells and giant multinuclear cells with vacuolate or homogeneous eosinophilic cytoplasm and fusiform cells occasionally arranged in meningeoma-like whorls. The experience gathered thus far shows that, so far as intracranial fibroxanthomata are concerned, predictions or conclusions regarding the course of disease and the probability of recovery should be made with reservation only.

Age Factors↗
PubMed1979

[Tuberous sclerosis with unusual retroperitoneal massive bleeding caused by monstrous hamartoblastoma in both kidneys. A case report].

This paper reports the case of a 22-year-old woman with tuberous cerebral sclerosis and monstrous angioleiomyolipomata in the two kidneys, who died of spontaneous retroperitoneal mass bleeding from the hamartoblastomata in both kidneys. The disease had not been diagnosed during life despite imbecility since early childhood and the presence of guiding peripheral symptoms in the form of Pringle's disease.

Adult↗
PubMed1979

[The human utilization of orally administered 15N-glycine].

In 7 convalescent patients we studied utilisation of a single dose of 15N-labelled glycine. In intervals we estimated total-N, urea-N, NH3-N and their 15N-abundances (urine). The following results were obtained. The peak of ammonium-15N appeared 25 minutes earlier than the peak of urea-15 N. The cumulative elimination of total-15N amounted to 25% of uptake after 24 hours and to 34.4% after 6 days. 12 hours after application 53% of the total amount, excreted within 6 days, were already eliminated. 24 hours after administration 80% of total-15N was urea-15N and 2.8% NH3-15N. Further we found correlations between N-balance (N-application minus excretion) and elimination of 15N-urea: If N-balance got more negative, the amount of cumulative elimination, the portion of urea-15N to total-15N and the percentage of elimination after 12 hours related to 6 days were elevated. That means that in stress condition utilisation of glycine to urea is higher and accelerated. The model seems acceptable, to get information concerning metabolic situation in a simple way.

Administration, Oral↗
PubMed1978

Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow.

Clinical and morphologic findings in the conversion of treated polycythemia vera to pancytopenia with hyperplastic bone marrow (refractory anemia or pancytopenia with hyperplastic bone marrow) are described in light of our own observation. The nomenclature associated with this condition (pancytopenia, chronic erythroleukemia, preleukemia) is not uniform, whereas the morphologic findings are virtually identical. Some patients subsequently develop acute leukemia. The prognosis in cases of refractory anemia with hyperplastic bone marrow following polycythemia vera is, independent of the subsequent acute leukemia, invariably terminal.

Anemia, Aplastic↗
PubMed1978

Connective tissue reactions to acid glutaraldehyde.

Acid glutaraldehyde, 2 per cent and 1 per cent, along with sodium hypochlorite, 5.5 per cent, was tested on the connective tissue of rabbits and rats. Two per cent acid glutaraldehyde was very destructive, whereas the NaCIO and 1 per cent acid glutaraldehyde were moderately irritating.

Aldehydes↗