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Biomedical subjects

H Malchow

Publications and source records attributed to H Malchow.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Carbohydrate infusion in internal diseases. A comparative study in metabolically health, liver diseased and diabetic patients. VII. Infusions of a glucose-fructose-xylitol mixture (relationship 1:2:1) over 48 hours].

3 groups (6 control persons, 6 patients with liver cirrhosis, 6 patients with diabetes mellitus) were infused with 20% (w/v) carbohydrate mixture (glucose/fructose/xylitol, 1:2:1) for 48 hours. The metabolical status was controlled in defined intervals by means of 39 different laboratory parameters. The infusion rate was supposed to be 0.25 g carbohydrates/kg B. W. and hour. There were no significant changes in blood glucose levels in any of the 3 groups. However we could observe a slight but constant increase in lactate and triglyceride concentrations. Free fatty acids and keton bodies were suppressed on a low level. Only the diabetics showed a significant renal carbohydrate loss with up to 15% of the amount administered. No clinically relevant side effects were observed.

Adult↗
PubMed1982

[Carbohydrate infusions in internal diseases. A comparative study in metabolically normal subjects, patients with liver diseases and diabetics. V. Infusion of a glucose-sorbitol mixture (ratio 1:1) for 48 hours].

Three groups (6 patients with liver cirrhosis, 6 patients with diabetes mellitus, 6 controls) have been infused for 48 h with a 20% (w/v) glucose/sorbitol-solution (1:1). The only group where the infusion rate of 0,25 g carbohydrates/kg/h could not be reached was the control group with 0,232 g carbohydrates/kg/h. We could not see any significant changes in blood glucose levels during the total infusion period. Sorbitol levels dropped very slowly after the end of the infusion, a time when sorbitol was still excreted in the urine. The concentration of triglycerides was steadily increasing. Besides there were no further changes compared to equicaloric glucose or glucose/fructose infusions.

Diabetes Mellitus↗
PubMed1981

Adrenaline sensitive adenylate cyclase in human gastric mucosa.

Basal and adrenaline-stimulated adenylate cyclase (AC) was studied in biopsy specimens of the gastric and duodenal mucosa from 112 individuals. AC activities were log normally distributed. AC of fundic and antral gastric mucosa responded to adrenaline in a concentration-dependent manner, that of the duodenal mucosa did not respond to adrenaline. The degree of activation in biopsies of normal gastric mucosa was similar to that of patients with chronic atrophic gastritis or patients antrectomized according to the Billroth method. AC in biopsies from cimetidine-treated peptic ulcer patients was less sensitive to adrenaline than AC in biopsies from untreated patients. The threshold concentration of cimetidine to inhibit adrenaline-stimulated AC in vitro was 10(-6) mol/l. The data provide evidence of an adrenaline-sensitive AC in cells other than parietal cells and show an inhibitory action of cimetidine on the catecholamine-sensitive AC in the human gastric mucosa.

Adenylyl Cyclases↗
PubMed1981

Comparative study with ranitidine and cimetidine on gastric secretion.

The inihibitory effect of various doses of ranitidine and cimetidine on pentagastrin stimulated volume, acid, and pepsin secretion was studied in 8 healthy volunteers. Both compounds inhibited all three variables in a dose dependent manner with an average ID50 of approximately 5 mg for ranitidine and of approximately 41 mg for cimetidine. On a molar basis ranitidine is about 11 times more potent than cimetidine. The duration of action of both compounds appears to be equally long.

Adult↗
PubMed1981

[Carbohydrate infusion in internal diseases. A comparative study of metabolically healthy persons and liver disease and diabetic patients. III. Glucose infusion over a 48-hour period].

6 metabolically healthy control persons, 6 patients with liver cirrhosis, and 6 patients with diabetes were infused for 48 hours with a 20 % (w/v) glucose solution. The infusion rate was 0,25 g glucose/kg body weight and hour. A constant surveillance of the metabolical status was performed by control of 39 different laboratory values. In all 3 groups, glucose infusion alone was sufficient for basal metabolic rate. This was shown by the inhibition of lipolysis as well as in the decreased catabolism. Only the diabetic group exhibited high blood-sugar values and an energy loss up to 10 % of the administered glucose. We could not observe any side effects.

Blood Glucose↗
PubMed1981

[Carbohydrate infusion in internal diseases. A comparative study of metabolically healthy persons and liver disease and diabetic patients. IV. Infusion of a glucose-fructose mixture (1:1 ratio) over a 48-hour period].

6 patients with liver cirrhosis, 6 patients with diabetes and 6 control persons were infused for 48 h with a mixed carbohydrate solution (glucose/fructose, 1:1). The infusion rate was supposed to be 0,25 g carbohydrates/kg and hour. The metabolical status was surveilled by 39 different laboratory values. The results showed that compared to a pure glucose solution blood glucose levels where decreased. Basic blood glucose levels were passed only in patients with diabetes mellitus. However, the glucose values were not as much elevated that permanent insulin administration would have been necessary. The antilipolytic, antiketogenic and anticatabolic efficacy was comparable to an equicaloric glucose infusion.

Blood Glucose↗
PubMed1981

[Carbohydrate infusions in internal diseases. A comparative study on metabolically normal patients, patients with liver diseases and diabetics. Aims, execution and statistics of the studies in long-term infusion of carbohydrates].

We present the problems, methodology and statistics of a large scale clinical trial concerning biochemical events and compatibility of carbohydrate infusions. The presented work serves as introduction to understand the following publications from this study. More specifically we show the results of 48-hour infusion of the following solutions: 1. Glucose, 2. Glucose/Fructose, 3. Glucose/Sorbitol, 4. Glucose/Xylitol, 5. Glucose/Fructose/Xylitol. Each of the infusion series was applicated to patients with liver cirrhosis; diabetes mellitus, and a metabolically healthy control group.

Carbohydrates↗
PubMed1980

Comparative study with ranitidine and cimetidine on gastric secretion in normal volunteers.

The inhibitory effect of ranitidine and cimetidine on pentagastrin stimulated volume, acid and pepsin secretion has been studied in eight healthy volunteers. Both compounds inhibit all measured components of gastric secretion in a dose dependent manner. On a molar basis ranitidine is on average 11.14 times for volume, 13.04 times for acid, and 9.74 times for pepsin secretion more potent than cimetidine as measured by the ID50-values.

Cimetidine↗
PubMed1980

[Ultrasonography--diagnosis of fistulas and abscesses in Crohn's disease (author's transl)].

An essential complication of Crohn's disease was diagnosed at an early time by ultrasonography in three young women suffering from a highly active form of this disease: intraabdominal fistulas could be demonstrated and documented. In two cases these fistulas were connected to an abscess. Early limited surgery was indicated in this particular situation; such surgery was performed and lead to fast improvement. The diagnostic value of ultrasonography in Crohn's disease with palpable abdominal tumor is demonstrated by these case reports.

Abscess↗