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Biomedical subjects

H Maibach

Publications and source records attributed to H Maibach.

At least 91 records · Page 5Linked to original sources
PubMed1978

Triclocarban: evaluation of contact dermatitis potential in man.

Triclocarban was subjected to a profiling of its dermatitis producing potential including irritancy (21-day cumulative irritancy potential and application to 213 normal controls), phototoxicity (method of Marzulli), predictive contact sensitization (modified Draize method), predictive phototesting and battery screening in 2200 dermatitis patients, in an effort to define its relative dermatitis potential. The allergic contact dermatitis potential of triclocarban following bar soap use appears minimal.

Carbanilides↗
PubMed1978

Animal models of percutaneous penetration: comparison between Mexican hairless dogs and man.

In an attempt to find better animal models for percutaneous penetration studies relevant to man, urinary excretion of 14C-labeled compounds was studied in the Mexican hairless dog and in man. With benzoic acid, progesterone and testosterone, the total absorption and maximum absorption rate were greater in man than in the hairless dog. As urinary excretion lasted days longer in the dog than in man, it is possible that the thin dog skin held the chemicals longer than man. Surface-counting experiments with a Geiger counter with a thin mica window protected by a special screen of fine stainless steel wires showed that benzoic acid and progesterone did persist on the dog skin far longer than on human skin. We conclude that the Mexican hairless dog has permeability characteristics significantly different from those of human skin.

Administration, Topical↗
PubMed1977

Influence of human skin surface lipids on protection time of topical mosquito repellent.

Skin surface lipids were extracted from volunteers who had been ranked according to the duration of protection from mosquitoes by diethyltoluamide. These lipids were analyzed by GLC-mass spectrometry for their fatty acid contents. Correlations were found between total skin lipid content and protection time of diethyltoluamide and between certain fatty acid concentrations in the skin lipids and the protection time of diethyltoluamide.

Administration, Topical↗
PubMed1977

Allergic contact dermatitis from sunscreen preparations complicating photodermatitis.

Two men with known histories of photosensitivity had apparent exacerbations of their dermatoses. Patch-testing showed the presence of allergic contact sensitivity to the sunscreens that they were using. The clinical distribution patterns of adverse reactions to sunscreens naturally simulate sun-induced reactions, thus providing clinical problems that require evaluation by both patch and photo-patch tests. These findings emphasize that allergic contact or photo-contact dermatitis from sunscreens that are used for prophylaxis of photodermatitis can actually complicate or aggravate the preexisting state of photodermatitis for which the sunscreens are prescribed.

Aminobenzoates↗
PubMed1976

Method of preparation and application of small quantities of semi-solid topicals.

Quantifying with accuracy small amounts of semi-solid viscus materials is critical in some situations. A sample dish and loading device for a micropipette is described which permits efficient and accurate loading and dispensing of microliter quantities. This is especially valuable for dealing with small quantities of radiolabelled viscus materials.

Administration, Topical↗
PubMed1976

Transepidermal water loss in adhesive tape induced dermatitis.

As an index of skin barrier function, transepidermal water loss (TEW) was investigated in subjects reactive to adhesive tapes. Tape reactive subjects showed no difference in TEW in untreated skin when compared to non-reactive subjects. Plastic tape and transparent tape produced varying degrees of dermatitis in reactive subjects; the TEW was increased up to 40-fold of the baseline values correlating with the degree of dermatitis. Paper tape and plastic film without adhesive did not produce dermatitis and increased water loss. Regeneration of skin damage was accompanied by a decrease of TEW values. The general problem of tape reactors and tape irritation is discussed.

Dermatitis, Contact↗
PubMed1976

Immediate hypersensitivity in hand dermatitis. Role of food-contact dermatitis.

A patient had a chronic hand eczema, presumably as a manifestation of atopy. Treatment resistance appeared due to handling certain foods that produced burning and stinging in the chronically eczematous skin and not in otherwise normal skin. Selected tests for delayed hypersensitivity and for immediate hyper sensitivity on intact skin of the back produced negative results, but on chronically inflamed skin of the arm and back, application of the pertinent foods produced a wheal and flare response. On intact skin, scratch tests with the foods produced positive results. Intradermal tests with commercial antigens were negative. Avoidance of these foods, as contactants, led to resolution of the dermatitis. Reappraisal of the role of immediate-type hypersensitivity in chronic hand eczema is important.

Eczema↗
PubMed1975

Acute laryngeal obstruction presumed secondary to thiomersal (merthiolate) delayed hypersensitivity.

A patient treated his slight score-throat with a thiomersal first aid spray. The next day, because of continued discomfort, he repeated its use. Laryngeal obstruction followed within hours. Emergency tracheostomy produced prompt improvement. Patch testing revealed an extreme spreading reaction to thiomersal. It is our interpretation that the acute laryngeal obstruction was delayed hypersensitivity to this first aid spray.

Acute Disease↗