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Biomedical subjects

H M Spiro

Publications and source records attributed to H M Spiro.

At least 91 records · Page 5Linked to original sources
PubMed1976

Serum lysozyme in inflammatory bowel disease.

Serum lysozyme activity was measured in 18 patients with ulcerative colitis and 40 patients with Crohn's disease by both the turbidimetric and lysoplate method. Only one patient with ulcerative colitis and eight patients with Crohn's disease had increased serum lysozyme activity by either or both methods. Both methods appeared equally sensitive in detecting increased serum lysozyme activity. In Crohn's disease, the percent with elevated values increased with increase in disease activity.

Colitis, Ulcerative↗
PubMed1976

Medical and surgical therapy in diverticular disease: a comparative study.

The course of 132 patients with documented acute diverticulitis was analyzed: 99 patients treated medically and 33 patients treated surgically were followed for an average of 9.2 years. Seventy-three per cent of the medical group and 79% of the surgical group had no further symptoms or hospital admissions as a result of their diverticular disease once they were recovered from the acute episode. For three-quarters of the patients, therefore, acute diverticulitis occurred as a single episode that responded to either medical or surgical management. Considering the morbidity and cost to the patient, the treatment of the patient recovered from acute diverticulitis should be medical, with operation reserved for complications.

Adult↗
PubMed1975

Medical and surgical management of reflux esophagitis. A 38-month report of a prospective clinical trial.

We compared the surgical and medical managements of reflux esophagitis in a prospective managements of reflux esophagitis in a prospective clinical trial. Patients wissigned to surgical (15 patients) and medical (16 patients) groups. A non-randomized medical group (20 patients) was also studied. Seventy three per cent of the surgical and 19 per cent of the medical group had an excellent to good response. A fair to poor response was observed in 81 per cent of medical and 27 per cent of surgical patients. Symptomatic improvement was accompanied by normal findings on acid infusion test and esophagoscopy. The histologic appearance of the squamous mucosa, however, remained abnormal in all but one patient. In patients who did well after operation there was improvement in resting lower-esophageal-sphincter pressures and absence of gastroesophageal reflux. The relative increases in pphincter pressure to graded increases in gastric pressure, however, remained abnormal in all but one patient.

Biopsy↗
PubMed1975

Influence of perfusion rate and compliance on esophageal manometry.

The accuracy of esophageal manometry using the conventional perfused three-lumen catheter depends on the proper choice of the perfusion rate. Previous investigators have used a wide range of perfusion rates without considering the compliance of the transducer-catheter assembly as a variable in the selection of the perfusion rate for the hydraulic systems. We present a relationship relating the perfusion rate and the compliance which specifies the minimum adequate perfusion rate for a given transducer-catheter assembly. This approach explains apparent discrepancies in the literature regarding the proper rate of perfusion for accurate measurement of esophageal contractions. Esophageal motility tests with 10 subjects confirmed the accuracy of manometric tests at the prescribed perfusion rate (1.25 ml/min) since they compared well with intraluminal pressures measured directly with a Honeywell intraesophageal transducer. The effect of perfusion rate on the apmlitude of esophageal contraction was also investigated and it is shown that high perfusion rates result in increased amplitudes of contraction. Furthermore, at large perfusion rates a large volume of liquid builds up in the esophagus. This fluid accumulation could possibly be responsible for the increased amplitudes of contraction.

Adult↗
PubMed1975

Glucagon secretion in acute and chronic pancreatitis.

Plasma pancreatic glucagon concentrations were determined in the basal state and after the infusion of alanine in 10 patients with acute pancreatitis (5 in an initial episode of pancreatitis), in 10 patients with chronic pancreatic insufficiency, and in 21 healthy controls. In acute pancreatitis, basal glucagon levels were nine times normal but were higher during the initial attack than with a history of previous attacks. The glucagon response to alanine was also increased threefold to fourfold in initial attacks. In contrast, after recovery from the initial attack of acute pancreatitis, during acute episodes of pancreatitis in patients with a history of previous attacks, and in patients with pancreatic insufficiency, alanine failed to elicit a consistent rise in plasma glucagon. The data suggest that hyperglucagonemia may contribute to the hyperglycemia of acute pancreatitis, particularly during the initial episode. Loss of alpha cell responsiveness to alanine provides a sensitive index of previous pancreatitis.

Acute Disease↗