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H M Spiro

Publications and source records attributed to H M Spiro.

At least 37 records · Page 2Linked to original sources
PubMed1988

The rise and fall of the psychosomatic hypothesis in ulcerative colitis.

We review the rise, in the 1930s, and the decline, in the 1960s, of medicine's attention to psychosomatic considerations in ulcerative colitis. Both the rise and decline of interest in psychosomatics resulted from trends outside of the published work which directly contested the issue. In particular, the "rise" period coincided with the heyday of the psychosomatic movement and the "fall" with the autoimmune theory, the introduction of steroids, and other trends. Finally, we offer a general critique of the way the debate over the psychosomatic hypothesis was conducted.

Colitis, Ulcerative↗
PubMed1987

Bubble-mania.

Explore the source record for details and available documents.

Dilatation↗
PubMed1986

Duodenal ulcer. Incidence, risk factors, and predictive value of plasma pepsinogen.

In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). We report a long-term follow-up of this cohort. A self-administered questionnaire designed to ascertain information about the development of peptic ulcers, and the presence of risk factors was mailed to 861 subjects with "active" addresses. A second questionnaire was mailed to each respondent's physician(s) to verify the diagnosis of DU. Completed questionnaires were returned, after three mailings, by 604 (70%) of the subjects. They reported 18 documented DUs, 15 since 1958, for an incidence of 1.1/1000 person years. Only smoking (P less than 0.05) and undergraduate physical inactivity (P less than 0.01) were identified as risk factors for DU. Family history; blood type; blood antigen secretor status; ingestion of coffee, alcohol, milk, salicylates, soda, or tea; and COPD were not identified as risk factors for DU. Patients with DU had higher mean PP values than those who did not (391.6 +/- 99.6 vs 346.6 +/- 106.7, mean +/- SD) but this was not statistically significant (P greater than 0.05). The predictive value of an elevated PP (greater than 450) for the development of DU was 7.9%, but a low or normal PP predicted the absence of a DU in 97.5% of subjects over a 22-year span.(ABSTRACT TRUNCATED AT 250 WORDS)

Duodenal Ulcer↗