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Biomedical subjects

H M Sandler

Publications and source records attributed to H M Sandler.

At least 73 records · Page 4Linked to original sources
PubMed1992

Spinal cord astrocytomas: results of therapy.

Spinal cord astrocytomas are rare lesions, usually of low grade, with a long natural history. Because of this, it is difficult to define the optimum approach to therapy based on available data. To provide more data, a retrospective review was performed. From 1975 through 1989, 21 patients were seen and treated (median age, 21 years), and 15 patients received radiation therapy after undergoing either biopsy or resection. The median time until death or the last follow-up examination was 41 months. The actuarial survival of all patients was 68% at 5 years. Of the five deaths, four were related to local tumor recurrence. The overall survival and recurrence-free survival of irradiated patients at 5 years was 57% and 44%, respectively. The age of the patient was a prognostic factor, with younger patients surviving substantially longer before recurrence. Of the 15 irradiated patients, 7 experienced recurrence of the tumor, which occurred within the irradiated portion of the spinal cord in all 7. Gross total resections were rarely achieved and, also, the extent of resection did not influence the risk for recurrence. In summary, we observed a long natural history for this disease, and although additional local therapy appears needed, it is unclear that either higher doses of radiation or more extensive surgery will decrease the risk of recurrence.

Actuarial Analysis↗
PubMed1991

Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy.

Hochberg and Pruitt have reported glioblastomas recurring within 2 cm of the primary site in 90% of patients after whole-brain radiation therapy. They suggested that computerized tomography (CT) scan accuracy would permit smaller radiation fields. A treatment protocol with smaller-field focal brain irradiation following surgical resection is reported. The first 4500 cGy of radiation is focused to within a 3-cm margin around the tumor, with a 1500-cGy boost within a 1.5-cm margin. Forty-two patients with grade III or IV astrocytoma, treated with focal brain radiation therapy were reviewed retrospectively to assess patterns of tumor recurrence. Thirty patients received intra-arterial bromodeoxyuridine (BUdR) radiosensitization with focal brain radiation therapy, and 12 patients underwent conventional focal brain radiation therapy. Tumor margin was defined on preoperative and recurrence CT scans as the contrast-enhanced area; these were traced on acetate templates and compared with each other and with the actual scans. In all 42 patients, the lesion recurred within a 2-cm margin of the original tumor. Four patients had two recurrent areas: the second area was within the 2-cm margin in two, and outside this margin in two. These results are similar to those of Hochberg and Pruitt. It is suggested that focal irradiation is now the optimal treatment for malignant astrocytoma. Since recurrences continue to be within the irradiated volumes, it appears that higher focal doses of radiation are appropriate for clinical treatment trials of malignant astrocytomas.

Brain Neoplasms↗
PubMed1990

The influence of tumor size and pre-treatment staging on outcome following radiation therapy alone for stage I non-small cell lung cancer.

From 1970 through 1987, 77 patients with Stage I lung cancer were treated with definitive radiation therapy (RT) alone at the Fox Chase Cancer Center or the Hospital of The University of Pennsylvania. All patients had a pathologic diagnosis of non-small cell lung cancer and were not candidates for surgical resection because of premorbid medical problems or patient refusal. The median age was 72 years, although 10 patients were over 80. The histologic cell type was squamous in 44, adenocarcinoma in 15, large cell in 3, adenosquamous in 1, non-small cell in 11, and bronchioli-alveolar in 3. Tumor size was retrievable in 75 patients and 25 were less than or equal to 3 cm, 41 from 3-6 cm, and 9 greater than 6 cm. Diagnostic staging varied during the study period. Twelve patients, evaluated with a CT scan of the chest, including the liver, and a bone scan were classified as having "excellent" staging, 24 patients with conventional tomography, liver-spleen scan and a bone scan had "good" staging, and 41 patients were staged less rigorously. The RT was of megavoltage energy in all patients. The median dose was 60 Gy. The mediastinum was treated in all but eight patients who had poor pulmonary function. Survival was measured from the date of pathologic diagnosis. The actuarial 3-year survival rate of the entire group of patients is 17% with a median survival time of 20 months. Of the 61 deaths, 51 were due to disease and 10 were due to intercurrent disease without evidence of tumor recurrence. The actuarial 3-year disease-specific survival (DSS) was 22%. The 3-year disease-specific survival for patients with tumors less than 3 cm and from 3-6 cm was 30% and 17%, respectively. All nine patients with tumors greater than 6 cm were dead of disease. Local progression occurred in 33 patients, resulting in a 44%, 3-year actuarial freedom from local progression. The median time to local failure was 28 months and there were no local failures after 3 years in the 18 patients eligible for observation beyond this point. Of the patients with "excellent" staging, only 2 of 12 were dead of disease compared with 22 of 24 with "good" staging and 30 of 41 of the remainder. In this large group of Stage I non-small cell lung cancer, thorough pre-treatment staging and smaller tumor size are associated with a more favorable outcome.

Aged↗
PubMed1989

Results of radiotherapy for thyroid ophthalmopathy.

Between October, 1978 and August, 1986, 35 patients with thyroid ophthalmopathy were treated with radiotherapy. Twenty-eight patients had treatment with corticosteroids prior to radiotherapy and either progressed on steroids or relapsed during tapering. Seven patients with contraindications to steroids were treated primarily with radiotherapy. After radiotherapy, 25 patients (71%) did not require any further steroids or orbital decompression and ten (29%) failed. Patients who required steroids or decompression for active disease after radiotherapy were considered treatment failures. A total of 14 (40%) patients required eye muscle or lid surgery for correction of stable soft tissue defects after radiotherapy, more commonly in patients treated with radiotherapy after steroids or decompression than those irradiated primarily; the median time between radiotherapy and surgery was 8 months (range 1-48). Various factors were examined for prognostic significance in predicting radiotherapy failure. Review of the interval between onset of eye disease and radiotherapy demonstrated that six of ten (60%) failures versus only five of 25 (20%) successful treatments received radiotherapy within 6 months of onset of eye disease. No relation between outcome and sex, age or hyperthyroid versus euthyroid Graves' disease was apparent. Radiotherapy has been used for patients with thyroid ophthalmopathy who failed steroids, decompression, or had steroid contraindications. Morbidity of radiotherapy was minimal and most patients were spared the morbidity of continued steroid therapy.

Adult↗
PubMed1988

Analysis of the possibility that transurethral resection promotes metastasis in prostate cancer.

The issue of transurethral resection (TURP) in patients with known prostatic adenocarcinoma is a current clinical controversy. Data have accumulated to associate this procedure with an adverse risk of distant spread and death for a defined subset of patients with moderate and poorly differentiated, T3 and T4 (Stage C) tumors. Review of available literature demonstrates that examination of this subset is incomplete in studies that do not find an adverse prognosis. The reason for the association of TURP and metastasis may be related directly to the resection via mechanical dissemination of tumor or indirectly through association with unknown adverse factors. Retrospective review may be unable to separate these two hypotheses, but hazard function analysis is presented and is consistent with surgical enhancement of metastases. Strategies for avoiding the adverse effect represent areas for possible further clinical research.

Adenocarcinoma↗
PubMed1982

Antecedents of child abuse.

The qualities of parents who batter their children have been determined by interviewing known abusers. Because most studies lack controls and because family characteristics may be changed by abuse, a prospective study was instituted. Fourteen hundred low-income mothers were interviewed in a prenatal clinic, and the characteristics of 23 reported for abuse within two years were compared to the characteristics of the remaining mothers. The predominant antecedents of child abuse were: unwanted pregnancy, aggressive tendencies, and aberrant childhood nurture in which disturbed family relationships were more important than outright abuse. Abusive mother had slightly less self-esteem. Factors which increased exposure between parents and children seemed to increase risk for abuse. In contrast to retrospective findings, abusive mothers did not differ in support available from others, age, education, isolation, family alcohol or drug problems, and expectations of child development.

Aggression↗
PubMed1982

Mother-infant interaction and child development after rooming-in: comparison of high-risk and low-risk mothers.

One hundred and seventy-two low-income women were interviewed prenatally to determine risk for later mistreatment of their children. High-risk and low-risk women were then randomly assigned at delivery to either limited or extended postpartum contact with their newborns over the first two days after birth. Mother-infant interaction observations were performed at 48 hours and at one, three, six, twelve and eighteen months postpartum. Infants were tested at nine months with the Bayley Scales of Infant Development. Results indicated that outcome following extended mother-infant postpartum contact varies with maternal risk status and measures employed for evaluation. Low-risk extended-contact mother-infant pairs differed from low-risk controls in observed interaction while high-risk extended-contact and controls did not differ from each other in interaction. High-risk extended-contact infants were more advanced in motor development than control infants at nine months, however, while low-risk extended contact and control infants did not differ in development.

Child Abuse↗
PubMed1980

Reduced incidence of parenting inadequacy following rooming-in.

Low-income mother-infant pairs were randomly assigned to rooming-in (N = 143) or to routine (N = 158) postpartum contact to determine whether rooming-in affects subsequent adequacy in parenting. At mean age 17 months, two rooming-in and ten control children had experienced inadequate parenting. One rooming-in and eight control children were hospitalized for these problems. One rooming-in and five control families were reported to Protective Services for mistreatment of the study child; five control and no rooming-in children were in the care of adults other than their parents at the time of data analysis. In this study, rooming-in correlated with fewer subsequent cases of parenting inadequacy.

Adolescent↗
PubMed1977

Maladaptive antisocial aggressive behavior and outlets for intimacy.

Psychotherapy research literature suggests that maladjustment and self-disclosure patterns are related. Male psychiatric patients (23-37 years) were selected according to a stratified random sampling procedure with conditions for Ss: (a) who actually have engaged in maladaptive antisocial aggression (N = 41); (b) who exhibited aggressive impulses, urges, or fantasies (N = 111); and (c) who served as patient (N = 105) and non-patient (N = 137) controls. Results of this study supported the prediction that those patients who actually engaged in maladaptive antisocial aggression employed fewer outlets for self-disclosure than any of the other patient or non-patient groupings. Clinical implications that concerned the actual range of an individual's outlets for intimacy as predictive of maladaptive antisocial aggression in male adults were discussed.

Adult↗
PubMed1976

Psychotherapy sabotage revisited: the better half of individual psychotherapy.

This study examined the amount of actual client self-disclosure emitted and the pattern of its occurrence within and across individual therapy sessions. An earlier finding showed that many clients avoided self-disclosure until the session's closing minutes early in therapy. These data revealed that in the middle stages of short-term therapy for a university population (N = 26) clients continue to engage in the highest proportion of self-disclosure during the latter half of the therapy hour. The position that there are ways in which psychotherapy sabotage can be reduced was discussed.

Adult↗
PubMedDate not supplied

Pelvic CT findings after radical prostatectomy.

OBJECTIVE AND METHODS: To evaluate the spectrum of pelvic CT findings in patients who have had radical prostatectomy, we retrospectively evaluated the pelvic CT of 17 patients after surgery for prostate cancer. All patients were thought to be clinically free of local recurrence of carcinoma. RESULTS: The bladder base was retropubic in 100%, the levator sling was well delineated in its entirety in only 88%, and fat was clearly demonstrated between the rectum and bladder base in only 44%. Unsuspected findings in this group included soft tissue density structures in the resected bed of the seminal vesicles (88%) and a transversely oriented, soft tissue density bar between the bladder base and rectum (53%). A variety of symmetric abnormalities are commonly seen on postprostatectomy pelvic CT. CONCLUSION: Seminal vesical-like soft tissue structures are routinely visualized, and a horizontal bar of soft tissue in the rectovesical space is commonly demonstrated. These structures should not be confused with local tumor recurrence.

Aged↗
PubMedDate not supplied

A meta-analysis of meausures of self-esteem for young children: a framework for future measures.

The objective of this study was to synthesize information from literature on measures of the self in young children to create an empirical framework for developing future methods for measuring this construct. For this meta-analysis, all available preschool and early elementary school self-esteem studies were reviewed. Reliability was used as the criterion variable and the predictor variables represented different aspects of methodology that are used in testing an instrument: study characteristics, method characteristics, subject characteristics, measure characteristics, and measure design characteristics. Using information from two analyses, the results indicate that the reliability of self-esteem measures for young children can be predicted by the setting of the study, number of items in the scale, the age of the children being studied, the method of data collection (questionnaires or pictures), and the socioeconomic status of the children. Age and number of items were found to be critical features in the development of reliable measures for young children. Future studies need to focus on the issues of age and developmental limitations on the complicated problem of how young children actually think about the self and what methods and techniques can aid in gathering this information more accurately.

Child↗
PubMedDate not supplied

Competent kids: children and adolescents with a chronic illness.

The social and personal competence of children and adolescents with a seizure disorder or an orthopaedic condition was assessed by parents and teachers. The contributions to these assessments of characteristics of the child, the intensity of the illness, and the child's temperament were explored using a hierarchical regression model. Parents and teachers rated all children as functioning fairly well. Children with a seizure disorder were perceived as significantly less competent than were their healthy peers (P less than 0.05). Across health status groups, children received higher competence scores from their parents than they did from their teachers (P less than 0.05). Competence scores did not differ according to the age of the child. The patterns of variables that predicted ratings of competence differed according to illness type and rater. Indicators of illness intensity explained a larger share of the variance in competence ratings for children with a seizure disorder (25%) than for children with an orthopaedic condition (5%). For children in this latter group, temperament explained a much larger proportion of the variance in both parents' (29%) and teachers' (42%) ratings of competence than did the illness intensity variables.

Adolescent↗