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Biomedical subjects

H M Pollack

Publications and source records attributed to H M Pollack.

At least 55 records · Page 3Linked to original sources

Imaging of renal trauma.

Because of complex variables and unsettled treatment issues, a standardized prescription for imaging the acutely traumatized kidney cannot be written. Imaging considerations are based on treatment considerations and will vary from place to place, from patient to patient, from physician to physician, and even from time to time in the same institution. The condition of the patient, the availability of resources and personnel, and (especially) whether existing treatment policy is conservative or aggressive will govern the selection of studies. Above all, since the kidney may be only one of several organs requiring immediate investigation, it is always the totality of the situation that sets the tone for the imaging process. A synthesis of prevailing thought is depicted diagrammatically in Figure 2 and is summarized as follows: CT is the most informative radiologic study in renal trauma and is the examination of choice in patients suspected of having serious renal injuries or associated injuries amenable to CT evaluation. CT is wasteful, however, in the stable, asymptomatic patient who is perceived to have only a minor, exclusively renal injury. Here, excretory urography is an acceptable alternative. Most of these patients will have normal findings at urography, all but ruling out significant renal damage. The vast majority of patients will fall into this category but for those whose urograms do not provide adequate information for management, CT is performed next. Sonography and radionuclide imaging, while advocated in some quarters, do not enjoy wide acceptance in the United States as first-line triage studies. They are usually reserved for selected situations, mainly for follow-up. Arteriography still has a place, primarily in preoperative road mapping, and for therapeutic interventions such as embolization of bleeding vessels and arteriovenous fistulas. The role of MR imaging has yet to be defined. The choice of imaging in renal trauma requires discretion, judgement, and common sense. Standard protocols are useful, but there is a place for flexibility and the customizing of individual approaches.

Diagnostic Imaging↗

Prostate: MR imaging with an endorectal surface coil.

An endorectal surface coil has been developed to obtain high-resolution magnetic resonance images of the prostate. The probe consists of a surface coil mounted on the inner surface of a balloon. The balloon is concave to ensure tight seating against the prostate. The coil has been used in 15 patients with biopsy-proved prostatic carcinoma and in two healthy volunteers. The axial images were obtained with a 12-16-cm field of view and a 3-mm section thickness. Compared with images obtained with a body coil, the surface coil images better demonstrate prostatic anatomy and pathologic conditions.

Humans↗

Rectal involvement by prostatic carcinoma: barium enema findings.

A retrospective study was performed to determine the radiographic features of prostatic carcinoma invading the rectum on double-contrast barium enemas. In 11 such patients, these examinations revealed localized narrowing and/or speculation of the rectum (four cases); a smooth, extrinsic mass impression on the rectosigmoid colon (two cases); an umbilicated submucosal mass in the rectosigmoid colon (one case); and rectosigmoid narrowing with spiculated, pleated mucosal folds in the narrowed segment of bowel (four cases). Thus, most patients (64%) had localized involvement of the rectosigmoid colon with sparing of the distal rectum. The anatomic-pathologic basis for the localized spread of prostatic carcinoma to the rectosigmoid colon is illustrated on MR scans. Thus, prostatic carcinoma invading the rectum may be manifested on double-contrast barium enema by a spectrum of radiographic findings, and most patients have localized rectosigmoid involvement with sparing of the distal rectum.

Adenocarcinoma↗

Age-related changes of the prostate: evaluation by MR imaging.

The pelvic MR examinations of 40 men without known prostatic disease were reviewed retrospectively. Axial long TR/long TE images were evaluated with respect to prostatic zonal size and signal intensity. Findings were correlated with each patient's age (17-74 years). The central region of the prostate and the peripheral zone enlarged with age; the central gland increased in size by an average of 175% between the second and eighth decades and the peripheral zone increased by an average of 67%. The anterior fibromuscular stroma decreased with increasing age (from an average anteroposterior thickness of 1.2 cm in the second decade to 0.4 cm in the eighth decade) and also became thinner as a function of increasing gland size. The periprostatic venous plexus became less prominent as a function of increasing age, decreasing from 2.5 to 1.5 mm in average maximal diameter, but this venous caliber was not significantly correlated with gland size. The conspicuity of the peripheral zone with respect to the central gland was improved, both as a function of increasing age and increasing gland size, and conspicuity was greatest on long TR/long TE images because of excellent contrast resolution. We conclude that in older age groups, the zonal anatomy of the prostate is more clearly defined than in young patients, both because of morphologic changes in prostate structure and because of physiologic changes resulting in differing zonal MR signal intensities.

Adolescent↗

Fluoroscopically guided pyeloureteral interventions by using a perurethral transvesical approach.

Using a perurethral transvesical approach, we attempted a total of 180 varied pyeloureteral uroradiologic interventional procedures during a 20-month period; 168 were successfully accomplished (93% success rate). We used standard interventional equipment, fluoroscopy, and (for access to the upper urinary tract) ureteral catheters that had been partially or completely inserted at cystoscopy by urologists. The successful procedures included insertion of double-pigtail ureteral stents (42 procedures), insertion of single-pigtail ureteral stents (47), advancement of arrested or incompletely inserted retrograde ureteral catheters (42), urothelial biopsy (30), balloon dilatation of ureteral strictures (three), retrograde cannulation of ureteropelvic junction obstructions that could not be negotiated in a percutaneous antegrade fashion (three), and ureteral stone extraction (one). The method was unsuccessful in 12 patients. Failures were due to caudal migration of a ureteral catheter into the bladder in eight patients and to an inability to advance a guidewire beyond an area of ureteral obstruction or perforation in four. Although most commonly used as an adjunct to extracorporeal shock-wave lithotripsy of renal and proximal ureteral calculi, the perurethral approach was extremely valuable for a wide variety of other indications. Significant complications, encountered in 5% of the procedures, included urosepsis (two), ureteral perforations (five), and cannulation of a false ureteral lumen (two). These problems resolved without sequelae with conservative management. The perurethral transvesical approach represents a relatively simple, safe, and expeditious interventional uroradiologic method. It frequently obviated other more invasive interventions such as percutaneous nephrostomy, ureteroscopy, or surgery.

Adolescent↗

Fluoroscopically guided retrograde brush biopsy in the diagnosis of transitional cell carcinoma of the upper urinary tract: results in 45 patients.

This is a retrospective review of 45 patients suspected of having transitional cell carcinoma of the upper urinary tract who underwent fluoroscopically guided retrograde brush biopsy at our institution during a recent 3-year period. All patients evaluated had an abnormal IV urogram or retrograde pyelogram in which the diagnosis of transitional cell carcinoma of the kidney or ureter was suspected or could not be excluded. The results of the brush biopsy were compared with the final diagnosis established at surgery or through clinical and surgical follow-up. Results of the biopsies were classified into five categories: (I) normal transitional epithelium (16 patients), (II) atypical cells (eight patients), (III) dysplastic cells (two patients), (IV) suspicious for malignancy (four patients), and (V) conclusive evidence of malignancy (eight patients). In four additional patients, other miscellaneous diagnoses were made, and in three others the procedure was nondiagnostic. Brush biopsies interpreted as Categories III, IV, and V had a positive predictive value of 100% (14/14) for the diagnosis of transitional cell carcinoma, and biopsies showing atypical cells (Category II) had a positive predictive value of 75% (6/8). Tabulating all diagnostic categories except for normal as a positive diagnosis, the procedure had a sensitivity of 91%, a specificity of 88%, and an accuracy of 89%. No significant complications were encountered. This experience suggests that brush biopsy is a valuable technique in patients suspected of having transitional cell carcinoma.

Adult↗

Small renal cell carcinomas: resolving a diagnostic dilemma.

Thirty-nine patients with pathologically proved renal cell carcinomas 3 cm or les in diameter were examined. Results of intravenous urography (n = 30) were true positive in 20 patients and false negative in ten (sensitivity, 67%). Renal ultrasound (US) (n = 29) had true-positive results in 23 patients and false-negative results in six (sensitivity, 79%); computed tomography (CT) (n = 36) had true-positive results in 34 and false-negative results in two (sensitivity, 94%). For selective renal angiography (n = 35%), the results were true positive in 26 and false negative in nine (sensitivity, 74%), with typical hypervascular renal cell carcinomas demonstrated in 17. Finally, the findings of percutaneous fine-needle aspiration biopsy were true positive in one of five patients when US guidance was used (sensitivity, 20%) and in five of eight when CT guidance was used (sensitivity, 62%). Small renal cell carcinomas are more frequently encountered in clinical practice than heretofore realized, and they are best imaged by CT.

Adult↗

Pseudoureteroceles following extracorporeal shock wave lithotripsy.

Routine follow-up urography demonstrated pseudoureteroceles caused by impacted calculus fragments in the distal portion of the ureter in five patients who had undergone extracorporeal shock wave lithotripsy of renal calculi 4-6 weeks before. Although all five patients showed some degree of obstruction at the time of follow-up urography, four were asymptomatic. Either small isolated fragments (two patients) or a column (steinstrasse) of fragments (three patients) was responsible for the abnormality. Two patients required further intervention to relieve the obstruction.

Adult↗

Calcified transitional cell carcinoma of the renal pelvis.

Six patients with calcified transitional cell carcinoma of the renal pelvis were encountered over a 10-year period, and the radiographic features in these cases are presented. Radiographically discernible calcification is one of the less common manifestations of this lesion, and the pattern of calcification may be variable. However, the combination of a coarse, punctate pattern with a mucosal lesion on excretory or retrograde urography should suggest the diagnosis and prompt further investigation.

Aged↗

Balloon catheter dilation of ureteroenteric strictures: long-term results.

Balloon catheter dilation of benign ureteroenteric anastomotic strictures has been proposed as an alternative to either surgical revision or chronic ureteral stenting, with moderately successful short-term results reported by several groups in a limited number of patients. However, the authors' experience with 29 patients exhibiting 37 benign ureteroenteric strictures treated over the past 7 years revealed that in the majority of cases (23 patients, 26 strictures [70%]), strictures recurred within 6 months of balloon catheter dilation/ureteral stent therapy. Furthermore, of the 11 strictures that appeared to have been successfully dilated at a follow-up interval of 6 months, five restenosed within 1 year. Therefore, only six of 37 (16%) ureteroenteric stricture dilations could be considered successful when viewed at least 1 year after interventional therapy. Furthermore, repeat dilations have often been required to maintain ureteral patency in these patients.

Adult↗

Urachal carcinoma: CT findings.

The computed tomographic (CT) appearance of urachal carcinoma in ten patients was studied and compared with the pathologic findings. Magnetic resonance images were available in one case. All tumors were mucinous adenocarcinomas; four were solid, three were cystic, and three were mixed. The tumor had a characteristic location along the expected midline course of the urachus directly behind the anterior abdominal wall. The main tumor mass was supravesical in eight patients. Seven tumors contained calcification. CT correctly depicted bladder wall involvement and supravesical extent of tumor in all cases. CT provided incorrect information about invasion of the perivesical fat in three patients and about bladder mucosal invasion in two patients.

Adenocarcinoma, Mucinous↗

Prostatic carcinoma: staging with MR imaging at 1.5 T.

Magnetic resonance (MR) imaging was used to stage prostatic carcinoma in 81 patients with a proved diagnosis. MR imaging findings were correlated with histologic findings regarding the local extent of disease (37 patieNts) and the presence of nodal metastases (51 patients). Tumor nodules were detected in the peripheral zone (PZ) in 34 of 37 patients and were of low signal intensity compared with the signal of the PZ. Hemorrhage in the PZ represented a problem in tumor detection and in tumor volume measurement. When multiple criteria for local tumor spread were combined, MR imaging had a sensitivity of 72%, a specificity of 84%, and an accuracy of 78% in the differentiation of stage A or B from Stage C or D disease. Assessment of seminal vesicle invasion was more accurate than assessment of direct extracapsular spread. In five patients, microscopic invasion of the capsule (stage C) was classified as stage B with MR imaging; from a clinical standpoint, this should not affect patient treatment and prognosis. The MR imaging sensitivity in the detection of lymph node metastases was 69%, with a specificity of 95% and an accuracy of 88%. In this study MR imaging proved reliable in the comprehensive evaluation and staging of prostatic carcinoma.

Aged↗

The development of steinstrassen after ESWL: frequency, natural history, and radiologic management.

Stone fragments that develop after extracorporeal shock-wave lithotripsy (ESWL) may lodge within the ureter. This column of fragments is referred to as a "steinstrasse" (plural, steinstrassen). We evaluated the first 1000 patients treated with ESWL at our institution to determine the frequency of steinstrasse formation, the clinical course of patients with steinstrassen, and the types of intervention, if any, required. Steinstrassen were seen in 20% of 1000 patients treated with ESWL. In 65% of the patients studied, the steinstrassen passed spontaneously. Of the remaining patients, all but 3% required treatment for ureteral obstruction. Seventy-five percent were treated urologically (ureteroscopy, ureteral catheterization), but 25% required radiologically directed intervention, either percutaneous nephrostomy or fluoroscopically monitored retrograde ureteral catheter/stent placement. Twenty-seven percent of our patients with persistent steinstrassen had silent obstruction. In view of the insidious manner in which kidney function may be jeopardized by steinstrassen, they should be managed with great circumspection. Radiologists dealing with steinstrassen should be skillful in both antegrade and retrograde methods of urinary tract intervention.

Humans↗

The role of MRI in diseases of the kidney.

The role of MRI in evaluating renal diseases has not yet been fully defined. Despite some inherent limitations due to motion and failure to confidently define calcifications, MRI can display normal and pathologic anatomy with great clarity. MRI is useful in the staging of renal carcinoma, especially in the evaluation of vascular invasion. Bulky tumors are best depicted with MRI, especially when the organ or origin is in question. Contrast agents, fast scan techniques, and spectroscopy hold great promise for the future.

Aneurysm↗