Biomedical subjects

H M Hittner

Publications and source records attributed to H M Hittner.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Examination of the anterior vascular capsule of the lens: II. Assessment of gestational age in infants small for gestational age.

Between the twenty-seventh and thirty-fourth weeks of gestation, the appearance of the anterior vascular capsule of the lens (tunica vasculosa lentis) has been established to be useful in accurately estimating gestational age. Thirty-three infants assessed by maternal dates and Dubowitz scoring were studied with the direct ophthalmoscope following dilatation of the pupil in the first 24 hours of life. Five discordant twins, eight concordant twins, and twenty singletons were determined to be markedly small for gestational age on the basis of birth weight (less than tenth percentile). As in infants who are appropriately sized for dates, the disappearance of the anterior vascular capsule of the lens in infants who are small for dates correlates well with their gestational age and is reliable for gestational age assessment (p less than 0.0005).

Female↗

PubMedDate not supplied

Examination of the anterior vascular capsule of the lens: III. Abnormalities in infants with congenital infection.

The disappearance of the anterior vascular capsule of the lens (tunica vasculosa lentis) in the preterm infant has been established to be useful in accurately estimating gestational age between the twenty-seventh and thirty-fourth weeks in infants appropriate or small for gestational age. Six infants have been studied with abnormalities of the anterior vascular capsule of the lens in which congenital TORCH infection has been documented (1 toxoplasmosis, 2 rubella, 2 cytomegalovirus, and 1 herpes simplex virus). Since the anterior vascular capsule generally atrophies symmetrically and completely after the thirty-fourth week of gestation, the findings of marked asymmetry and/or persistence and hypertrophy of the anterior vascular capsule of the lens warrants initiation of TORCH studies in the newborn infant.

Cytomegalovirus Infections↗

PubMedDate not supplied

Autosomal dominant ophthalmologic disorders and linkage.

A consideration of the currently established autosomal dominant linkage relationships to ophthalmologic disorders was utilized to review the principles of linkage. If cross-over does not occur, as few as 6 informative matings can be utilized to identify probable linkage, and as few as 11 informative matings can be utilized to establish linkage. The potential implications of linkage in diagnosis, prevention, and treatment of heritable disorders was discussed.

Acid Phosphatase↗

PubMedDate not supplied

Congenital retinal disinsertion syndrome.

The congenital retinal disinsertion (CRD) syndrome refers to cases of retinal detachment with disinsertion and may be divided into two groups. Group 1 reported by Hovland and co-workers includes healthy children with bilateral detachments and giant tears nasally, lens coloboma, and center anterior and posterior cortical lens opacities. Group 2 includes healthy children with a unilateral detachment often associated with microphthalmos and catatract. The opposite eye may show a combination of changes including small central anterior and posterior cortical lens opacities, lens colobomas, and paving-stone degeneration. The patients may have an increased risk of developing a detachment in the second eye, and some of these eyes have been treated with cryopexy. Seven patients belonging to group 2 have been described and four of these had unilateral cataract and microphthalmos. Two other patients had some degree of unilateral microphthalmos. Small central anterior or posterior cortical lens opacities were found in five eyes, and lens colobomas were found in two eyes. Six out of seven patients had varying degrees of paving-stone degeneration temporally in the nondetached eye. The CRD syndrome was familial in two patients who were sisters. Pathologic studies were done in the eyes of three patients.

Child↗