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Biomedical subjects

H M Goodman

Publications and source records attributed to H M Goodman.

At least 289 records · Page 16Linked to original sources
PubMed1969

Relationship between growth hormone and muscular work in determining muscle size.

1. Growth hormone reduced the loss of weight or induced net growth of denervated soleus and plantaris muscles in hypophysectomized rats.2. Growth hormone did not alter the weight of the denervated muscle relative to its contralateral control, i.e. the hormone increased the sizes of denervated and control muscles proportionately.3. Similarly treatment with the hormone appeared to cause proportional growth in muscles undergoing work-induced hypertrophy and their contralateral controls.4. It is suggested that muscle size is determined by at least two independent factors, growth hormone and muscular work. Growth hormone appears to act as a biochemical ;amplifying system' for the cell's anabolic machinery and determines the absolute changes in muscle size which result from changes in muscular work.

Animals↗
PubMed1969

Relationship between cortisone and muscle work in determining muscle size.

1. Large doses of cortisone caused marked atrophy of the plantaris muscle and other pale muscles of hind limbs of hypophysectomized rats, but hormone treatment had little effect on the size of the red soleus muscle.2. Denervation increased the sensitivity of the soleus and plantaris to the catabolic effects of cortisone.3. Increased work induced by tenotomy of the synergistic gastrocnemius made the plantaris muscle less sensitive to cortisone-induced atrophy.4. Since the catabolic effects of cortisone are more pronounced in the less active muscles, it is suggested that in mobilizing body protein for gluconeogenesis the hormone spares those muscles physiologically most active.5. The rapidity with which muscles lose weight in response to cortisone indicates that the hormone must decrease protein half-lives as well as decrease protein synthesis.

Animals↗