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Biomedical subjects

H M Dick

Publications and source records attributed to H M Dick.

115 records · Page 7Linked to original sources
PubMedDate not supplied

Massive osteoarticular allografts in the reconstruction of extremities following resection of tumors not requiring chemotherapy and radiation.

Since 1976, 70 osteoarticular allografts have been used to reconstruct extremities from which tumors not requiring chemotherapy or radiotherapy have been resected. Allografts excised from cadavers were stored in the vapor phase of liquid nitrogen in liquid nitrogen freezers (-150 degrees) after exposure to 15% glycerol. Prior to their use, the allografts were thawed rapidly in either tissue culture or balanced salt solutions. Following resection of the tumor, the excised bone was replaced with allografts that were rigidly internally fixed with plates and screws or, occasionally, with intramedullary rods. Patients were observed carefully for complications and were subjected to functional evaluations. Complications did not include alterations suggestive of a pronounced immunologic response to the graft. Five patients developed either local recurrences or distal metastasis. Of the remaining 65 patients, followed for one year or longer, osteochondral allografts performed satisfactorily in 55 (84.6%). This group included eight patients with initial complications that were successfully treated. The group of ten patients with unsatisfactory results included four patients with fractures of the grafts, one with fragmentation of the humeral head, three with infections, and two with joint instabilities. Since all patients had either hemi-joint or quarter joint replacements, the overall results achieved so far have been rewarding. However, continued long-term observations of patients with allografts are indicated, as are studies that would allow for the improvement of cartilage preservation, decrease the incidence of fractures, and improve rigidity of internal fixation. The incidence of infection can be reduced by the improvement in surgical technique, particularly with reference to the wound closure.

Adolescent↗
PubMedDate not supplied

Massive allograft implantation following radical resection of high-grade tumors requiring adjuvant chemotherapy treatment.

Since 1976, the authors have performed a total of 36 resections of malignant tumors of the limbs with reconstruction of these by implantation of allografts. All allografts have been supplied by the University of Miami Tissue Bank. Following resection of the long-bone tumor and obtaining acceptable margins, the allograft was inserted to the limb defect with three different techniques: (1) in addition to a custom prosthesis as a hemi-joint reconstruction, i.e., a custom Neer prosthesis and proximal humerus allograft; (2) an osteoarticular graft to replace an articular surface resected with the metaphyseal-diaphyseal portion of the tumor; and (3) an intercalary diaphyseal-metaphyseal graft replacing the resected tumor but preserving the recipient articular surface. Of the 36 tumors, one was in Stage III disease. The remainder were Stage II A or B by the System of Enneking. All of these patients had adjuvant chemotherapy. The follow-up time was 24 months to 96 months. The resection of tumors in 36 patients and treatment with postoperative chemotherapy resulted in a mortality of eight out of 36 and one amputation due to recurrence. Satisfactory results were obtained in 19 of 36 patients. If the tumor failures (eight deaths) and the amputation are subtracted from this number, the success rate is 70% (19/27). Intercalary grafts were more successful than osteoarticular grafts. Chemotherapy was started one to two weeks postoperation for all but four patients to whom it was also given preoperation. These patients were in a Children's Cancer Study Group (CCSG) protocol for prospective study of the effects of preoperative chemotherapy. There was no apparent difference in the allograft success in these patients as compared to patients receiving only postoperative chemotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Adjuvant arterial embolization in the treatment of benign primary bone tumors in children.

This report presents an initial clinical experience with arterial embolization as adjuvent therapy in the surgical treatment of selected benign primary bone tumors in childhood. Embolization was dramatically effective in 4 children with spinal or pelvic vascular tumors. This technique facilitated local surgical resection and/or curettage. No child had evidence of local recurrence. Three of the 4 children had spinal cord or nerve root compression resulting in various degrees of paralysis prior to surgery. All treated patients had complete recovery from their paralysis. There were no complications of embolization or surgery. The treatment of benign primary bone tumors of the spine and pelvis is immeasurably improved by the adjuvant arterial embolization procedure. The immediate surgical treatment of these difficult tumors now becomes feasible with the greatly diminished blood flow resulting from embolization.

Adolescent↗
PubMedDate not supplied

Radiological manifestations in 200 patients with ankylosing spondylitis: correlation with clinical features and HLA B27.

The radiological manifestations of 200 patients with ankylosing spondylitis were appraised, and correlated with the patient's sex, anterior uveitis, and HLA B27. Radiological findings in female patients were no different from male patients. Only syndesmophyte formation in the spine was found significantly more frequently in patients with uveitis and HLA B27. Osteoporosis of the spine correlated strongly with a later age of onset, longer duration of the disease, older age at the time of study, Romanus lesions, syndesmophytes, spinal fusion, osteitis pubis, and widespread radiological destructive peripheral joint disease. Syndesmophytes were most frequently present at the dorso-lumbar junction. Spondylodiscitis was present in 8 patients and was most commonly present in the thoracic spine.

Adolescent↗
PubMedDate not supplied

Biomechanics and comparison of two operative methods of treatment of complete acromioclavicular separation.

Sixty-three complete acromioclavicular separations were treated by 2 operative methods. Acromioclavicular wiring gave 73% acceptable results while wire or Dacron coracoclavicular loop gave 94% acceptable results. Complications, especially broken, bent, or backed-out wires were common with acromioclavicular wiring. Of 44 patients treated by acromioclavicular wiring, 5 required late distal clavicle resection and 4 of these had retained menisci. Loop fixation is mechanically superior since the loop is in the direction of the tensile forces. In acromioclavicular wiring, however, the fixation Kirschner wires are subjected to high bending moments. Loop fixation avoids violation of the acromioclavicular joint but does not restrict rotation of the clavicle. The operation is simple to perform and postoperative immobilization is minimal. Woven Dacron may be superior to surgical wire for loop fixation in that unlike wire it does not require removal by a second operation. Woven Dacron may also stimulate coracoclavicular ligament reconstitution.

Acromioclavicular Joint↗