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Biomedical subjects

H M Dick

Publications and source records attributed to H M Dick.

At least 73 records · Page 4Linked to original sources
PubMed1978

Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms.

HLA antigen frequencies were determined in patients who had suffered adverse reaction to the beta-adrenergic blocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include two separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe form of reaction, sclerosing peritonitis, were analysed separately from those with other lesion e.g. ocular symptoms, but did not show any significant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to selection bias.

Epitopes↗
PubMed1977

Lengthening of the ulna in radial agenesis: a preliminary report.

In two patients with bilateral radial agenesis, the ulnas were divided and lengthened in a modified Abbott-Anderson device with a gear box controlled by an electric motor to obtain from one to 2 mm. per day of gradual distraction. Three centimeters of length was achieved in 3 weeks. Bone bridged the gap in 3 months and was mature in 6 months. Repeat osteotomy and lengthening was done 12 to 18 months later. All secondary lengthening operations required bone grafts. Total length gained ranged from 5.4 to 6.4 cm.

Bone Lengthening↗
PubMed1977

Bioassay of kinship in northwestern Europe.

Kinship of Barra (Outer Hebrides) is bioassayed as 0.0096 relative to northwestern Europe, in reasonable agreement with prediction of 0.008 relative to Britain. The exponential decline of kinship with distance is similar to Scandinavia. Kinship of larger populations is consistent with predictions from isolates. Kinship is largely due to local drift rather than Norse admixture, the estimate of which is obscured by drift and appears highly unreliable. Other populations in northwest Europe, including Iceland, Lewis and Orkney, give estimates of kinship which reflect drift and geography, but also do not provide reliable estimates of admixture. Bioassay of kinship from gene frequencies gives observations to be explained in terms of migration and drift, but contributes nothing to the question of whether polymorphism in the species is maintained by neutral mutation or selection. Although the latter is on various grounds more likely, no calculations based on gene frequency distribution can provide critical evidence.

Emigration and Immigration↗
PubMed1977

Distribution of HLA antigens in patients with mycosis fungoides.

19 patients with plaque-style mycosis fungoides have undergone determination of HLA antigen distribution. Deviations from the expected distribution frequency occurred with the antigens of the W19 group comprising A29, W30, W31 and W32 and of B8 and A1. The W19 group deviation was statistically significant (chi2 = 9.7 p value less than 0.005). The significance of this observation in relation to reported immunological abnormalities in mycosis fungoides is discussed.

Adult↗
PubMed1976

Studies on the nature of autoimmunity in myasthenia gravis. Evidence for an immunodeficiency type.

Clinical and laboratory data continue to support the concept of a genetically determined breakdown of immunological tolerance in myasthenia gravis with immunological damage to the motor end plates. The demonstration of impaired function of thymus-derived lymphocytes and of IgA deficiency correlate well with the clinical data in which there is an increase incidence of autoimmune diseases associated with anergy. Whilst the exact pathogenesis of myasthenia gravis is unknown, the available data support the concept of an immune deficiency disorder.

Antibody Formation↗
PubMed1975

Transnavicular perilunate dislocations.

A complex injury of the wrist, the transnavicular perilunate dislocation, is analyzed along with a review of the literature. A method of management is proposed for this injury based on experience gained with nine such injuries. Our conclusion is that open reduction and internal fixation is a necessity unless an anatomic manipulative reduction can be accomplished. It is proposed that a navicular bone graft be employed at 6 weeks if avascular necrosis of the navicular and early signs of nonunion are evident. The rationale for these proposals is discussed.

Adolescent↗
PubMed1975

The association between HL-A antigens ankylosing spondylitis and sacro-iliitis.

The second series antigen W27 has been found to have an increased frequency in ankylosing spondylitis (82 per cent of 17 patients) and juvenile rheumatoid arthritis (Still's disease) (29 per cent of 24 patients). Three family studies are presented, including one in which the antigen W27 occurs both in the absence and the presence of ankylosing spondylitis. It is suggested that this family illustrates that the relationship between W27 and sacro-iliitis is affected by non-HL-A genes. The development of clinical disease depends upon the coincidence of several factors in one individual, some of which are genetically controlled by two or more loci which are not necessarily linked.

Adolescent↗
PubMed1975

Combined analysis of three studies of patients with Burkitt's lymphoma.

Data from the three preceding studies on the possible relationship of HL-A type with Burkitt's lymphoma were combined to see whether any trends in the data, not significant in the individal studies, would show significance when the three groups were combined. A statistical method for combining data from different studies is developed. Although in this analysis even the combined data failed to show any significant association of HL-A type with disease, it is suggested that the statistical methods used will be helpful in analysing other sets of data where it seems desirable to combine information from several studies.

Burkitt Lymphoma↗