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Biomedical subjects

H M Ali

Publications and source records attributed to H M Ali.

At least 37 records · Page 2Linked to original sources
PubMed1988

Problems in assessing rationality of drug utilization in less developed countries.

Less developed countries are facing various difficulties in assessing rationality of drug utilization. The problems are essentially related to four major areas; (a) Policies, administration and management, (b) Practice and services, (c) Education and training, (d) Monitoring and research. Drug policies have often failed to recognise the importance of identifying the levels of rationality of the various components of drug utilization. Consequently, neither the need nor the mechanisms to assess rationality were considered. Drug utilization data and records have been poorly developed and maintained, e.g. mal-managed, inaccurate, and without continuity with regard to collection, monitoring and evaluation. Provision and supply of drugs were handled by an unnecessary multiplicity of departments and state offices, none of which keeping complete records and/or information in relation to needs of drugs nor other health care requirements. Deficiencies and shortcomings associated with medical/pharmaceutical practice, services, education and training have as well contributed significantly to the failure of the less developed countries to assess and promote rationality of drug utilization.

Developing Countries↗
PubMed1988

The susceptibility of breast-fed and cow's milk formula-fed infant guinea pigs to upper respiratory tract infection with influenza virus.

Breast-fed infant guinea pigs from immune mothers were partially protected against infection with influenza virus when compared to those from nonimmune mothers. Virus titres in nasal washes at 24 h post-infection were reduced and virus clearance from the upper respiratory tract accelerated. When infants of immune mothers were deprived of colostrum and hand-reared on a formula-feed their ability to reduce virus yields at 24 h post-infection was lost. Infants partially breast-fed and partially formula-fed gave total virus yields similar to their fully breast-fed peers. Infants of immune mothers possessed high titres of serum IgG antibody to the virus prior to infection. Post-infection, IgG antibodies appeared on the mucosal surface of breast-fed seropositive infants earlier than for seronegative infants of nonimmune mothers but IgM and IgA responses of seropositive infants were less vigorous than those of seronegative infants. There was little evidence that antibody present in a mother's milk was transmitted to the nasal mucosa of her offspring. Fully and partly formula-fed seropositive infants showed enhanced transudation of serum IgG antibody on to the mucosal surface and this effect was most marked in the partly formula-fed group which showed greater protection. In both formula-fed groups serum and nasal IgM and IgA responses were completely suppressed.

Animals↗
PubMed1987

Propranolol disposition in patients with hepatosplenic schistosomiasis.

Eight Sudanese patients with hepatosplenic schistosomiasis and seven Sudanese controls were administered a single oral dose of long acting (LA), propranolol 160 mg; blood propranolol levels were measured at regular intervals for 12 h using g.l.c. In patients with hepatosplenic schistosomiasis, propranolol blood concentrations were greater (P less than 0.05) at all time intervals, Cmax 63.5 (29-143) ng ml-1 (median and range) than controls Cmax 23 (12-37) ng ml-1. Median AUC0-12 was also greater (P less than 0.05) (533 and 218 ng ml-1 h respectively), tmax were not significantly different. In patients and controls prior to treatment, standing heart rate (77.5 (60-110), 72 (68-74) beats min-1) systolic (120 (105-150), 110 (100-120) mm Hg) and diastolic blood pressure (75 (60-90), 70 (60-80) mm Hg) were not significantly different. However following propranolol administration a reduction (P less than 0.05) occurred in both systolic (median 20 mm Hg) and diastolic (median 12.5 mm Hg) blood pressure in the patients compared with controls. Heart rate was reduced by a median of 10 beats min-1 in both groups. These observations indicate that propranolol bioavailability in patients with hepatosplenic schistosomiasis is increased possibly due to reduced presystemic extraction.

Adolescent↗
PubMed1986

Oltipraz: administration with food increases its anti-schistosomal activity.

In a previous study it was demonstrated that the concentration of oltipraz in the plasma of human volunteers was significantly elevated when administered with food. In this study we attempted to determine if this food-induced increase was associated with an increase in the drug's anti-schistosomal activity. The drug was administered with and without food to two groups of patients infected with Schistosoma mansoni. The concentration of oltipraz in the plasma of these patients was measured at varying intervals after dosing. Results indicate that the food-induced increase in the bioavailability of oltipraz in patients with S. mansoni produces a significant increase in the drug's anti-schistosomal activity.

Administration, Oral↗
PubMed1986

Metronidazole metabolism following oral benzoylmetronidazole suspension in children with giardiasis.

A suspension of benzoylmetronidazole (6.4% w/v) was given orally at a dose of 15-25 ml, equivalent to 0.6-1 g metronidazole, once a day for three days to 11 children with giardiasis. Blood samples were collected after the first and third doses for analysis of plasma metronidazole and its main oxidative metabolite by high performance liquid chromatography. Peak metronidazole concentrations were 22.60 +/- 8.52 mg/l (mean +/- S.D.) after the first dose, and 30.22 +/- 10.06 mg/l after the third dose, occurring at 3.6 +/- 1.4 and 4.4 +/- 2.9 hours post-dose, respectively. Peak concentrations of the metabolite were 4.26 +/- 1.94 mg/l after the first dose and 7.96 +/- 3.63 mg/l after the third dose, occurring 7.2 +/- 1.6 and 9.1 +/- 3.3 h post-dose, respectively. Calculation of plasma metronidazole half-life and clearance values was not possible. This study shows that oral administration of metronidazole as its benzoyl ester slows the rate of metronidazole absorption, followed by sustained plasma concentrations and a prolonged elimination phase. Giardiasis does not appear to prevent metronidazole absorption. Concurrent giardiasis is unlikely to influence metronidazole therapy for systemic anaerobic infections.

Administration, Oral↗
PubMed1985

Chloroquine and premature evacuation of uterine conceptus in rats.

Bilateral spaying on day 18 of pregnancy in rats made the refractory uteri highly reactive to a single injection of chloroquine (25 mg/kg). Complete evaluation of the uterine conceptus resulted by 24-48 hours following chloroquine administration. It was moreover observed that the amount of luteal progesterone which was found to be sufficient to maintain pregnancy until term, failed to reverse the abortifacient efficacy of chloroquine.

Animals↗
PubMed1985

Investigations on the influence of liver diseases on ampicillin body levels in man.

Ampicillin bioavailability was examined using the urinary excretion method, in healthy subjects and patients with: viral hepatitis, primary hepatocellular carcinoma and hepatosplenic schistosomiasis. A single dose of 500 mg ampicillin was administered intravenously in each case. Viral hepatitis patients gave similar results to healthy subjects. Primary hepatocellular carcinoma and hepatosplenic schistosomiasis patients had reduced drug bioavailability compared to healthy subjects (P less than 0.001).

Adult↗
PubMed1985

Reduced ampicillin bioavailability following oral coadministration with chloroquine.

Ampicillin bioavailability was examined in seven healthy adult male volunteers after oral coadministration with chloroquine using the urinary excretion method. Ampicillin (500 mg, capsules) and chloroquine phosphate (250 mg, tablets) were administered in single doses of 1.0 g each. Each subject received, on two different occasions, ampicillin alone and ampicillin together chloroquine. Urine was collected hourly for 8.0 h. Ampicillin urinary levels were measured chemically. The mean % dose excreted, maximum peak of excretion and the time of that peak after the administration of ampicillin alone were: 29 +/- 4.1%, 1.73 +/- 0.27 mg/min and 1.75 +/- 0.164 h, respectively. The corresponding values after coadministration of ampicillin with chloroquine were: 19 +/- 2.9%, 1.25 +/- 0.17 mg/min and 1.82 +/- 0.210 h. The results indicate a significant reduction (P less than 0.005) in ampicillin bioavailability following oral coadministration with chloroquine. The reduction of ampicillin bioavailability produced by chloroquine might be attributed to slowing of gastric emptying and enhancement of gut motility induced by the chloroquine.

Administration, Oral↗
PubMed1985

Clindamycin for the treatment of falciparum malaria in Sudan.

Clindamycin, 5 mg/kg twice a day for 5 days, was used to treat falciparum malaria after clinical and parasitological diagnosis at a health station in Faki Hashim, a suburb of Khartoum, Sudan. Twenty out of twenty-six patients enrolled completed the study. Giemsa-stained thick blood films were negative for asexual parasites by day 7 in 17 patients and by day 8 in the remaining 3. All were examined on days 14 or 28; 2 who had initially been cleared by day 6 had asymptomatic low density asexual parasitemia on day 14, which disappeared without treatment by day 28, and 2 others initially cleared by day 5 were similarly positive at day 28. Reinfection in these patients cannot be ruled out. Of the 6 patients withdrawn from the study, 2 took chloroquine independently, 1 developed vomiting, 1 developed diarrhea, 1 acquired a circumoral maculopapular rash, and 1 had an increasing parasitemia on day 3 and was switched to chloroquine. Generally, the treatment was without toxicity and was well received. Clindamycin proved satisfactory for the treatment of simple cases of falciparum malaria in the field in Africa.

Adolescent↗
PubMed1984

Diet-controlled blood levels of oltipraz in healthy male subjects.

The bioavailability of the new antischistosomal agent, oltipraz, was examined under three different dietary conditions in seven healthy males. Oltipraz tablets (500 mg) were administered in single doses (25 mg/kg) under fasting conditions, with a low fat meal (less than 5% fat) and a high fat meal (24% fat). The extent and rate of oltipraz bioavailability were significantly increased by concurrent administration of the drug with food, as demonstrated by the increase in the plasma peak concentration, the area under the plasma concentration vs. time curve and the absorption rate constant. The plasma peak concentration was also reached earlier. Oltipraz plasma concentrations, following its administration under fasting conditions, were almost negligible. The likely mechanisms underlining oltipraz-food interaction are discussed.

Adult↗
PubMed1984

Effect of cysteine on oltipraz blood levels in green monkeys (Cercopithecus aethiops).

Oral coadministration of oltipraz, an antischistosomal compound, with cysteine to green monkeys (Cercopithecus aethiops) led to a marked increase in both the extent and rate of oltipraz bioavailability. The drug blood levels were monitored using a single extraction gas-liquid chromatographic assay. When 6 healthy adult animals were given oltipraz together with cysteine in a crossover study, peak serum concentrations, areas under the curve and absorption rate constants of oltipraz were on average 7 times greater than when the drug was administered alone. Oltipraz peak serum concentrations were reached 1 h earlier as a result of cysteine administration (2 h after dosing). At present, the mechanisms responsible for the effect(s) of cysteine on oltipraz bioavailability have not been identified. The marked increase in oltipraz bioavailability produced by coadministration of cysteine, irrespective of the exact mechanisms involved, may have significant clinical implications with regard to the treatment of schistosomiasis. Our results also indicate that oltipraz blood levels seem to be influenced by some sex-related factors. Male monkeys had higher oltipraz blood levels than females. These sex-induced differences were more evident in oltipraz-cysteine-treated monkeys.

Animals↗
PubMed1979

Artifacts produced by using dichloromethane in the extraction and storage of some antihistaminic drugs.

The use of dichloromethane for the extraction of amines may lead to the formation of artifacts. Dichloromethane reacts rapidly (37.5 degrees) with brompheniramine, diphenylpyraline, cyclizine, cyproheptadine but not with antazoline and lignocaine. This difference in reactivity as well as the thin-layer chromatographic, gas-liquid chromatographic, nuclear magnetic resonance, and mass spectrometric characteristics of cyclizine and diphenylpyraline chloromethochlorides are investigated.

Chromatography, Gas↗