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Biomedical subjects

H Lunt

Publications and source records attributed to H Lunt.

31 records · Page 2Linked to original sources
PubMed1994

The prognostic significance of urinary albumin in Polynesians with non-insulin-dependent diabetes.

Polynesian (59 Maori and 30 Pacific Island) patients were identified from two diabetes clinic registers and followed for a mean of 4.8 years, in order to determine the prognostic significance of urinary albumin excretion. Events were defined as death or entry onto a renal replacement programme. Fourteen events occurred during the period of follow-up. Urinary albumin/creatinine ratio was treated as a continuous variable in a proportional hazards analysis. A 10-fold increase in albumin/creatinine ratio was associated with a 5-fold increase in the risk of an event (95% C.I. = 2.05-12.09). In conclusion, elevated urinary albumin/creatinine predicted mortality and renal morbidity in Maori and Pacific Island patients with non-insulin-dependent diabetes.

Albuminuria↗
PubMed1993

Prevalence of insulin self manipulation in young women with insulin dependent diabetes.

AIMS: 1. To determine the prevalence of insulin self manipulation for the purposes of weight control, in a population based study of young women with insulin dependent diabetes. 2. To compare the North Canterbury prevalence of insulin self manipulation with figures reported in overseas studies. METHOD: All women with insulin dependent diabetes aged 18 to 30 years inclusive and resident in North Canterbury, were invited to an interview to document their diabetes self-care behaviour. A blood sample was taken at the time of interview for measurement of glycated haemoglobin. RESULTS: Ninety three percent of eligible women agreed to participate in the study. Twelve of the 69 participating women (17%) admitted to reducing their insulin dose at some time in the past, for the purposes of weight loss. This figure is significantly lower than the 37% (p = 0.047), reported from a British study, and the figure of 39% (p = 0.006), reported from the United States. The median glycated haemoglobin of the twelve subjects who reported manipulating their insulin was slightly higher than that of the remaining 57 subjects, but this difference did not reach statistical significance (79 mmol/mol haem versus 71 mmol/mol haem, p = 0.07). CONCLUSIONS: The self reported prevalence of insulin manipulation for the purposes of weight loss appears to be lower in North Canterbury, compared to overseas studies. The reason for this difference is unexplained. Health care professionals should nevertheless be aware of this method of weight reduction, as it has been associated with poor diabetes control, clinical eating disorders and possible long term detrimental effects on health.

Adolescent↗
PubMed1993

Comparison of Maori and European access to the Christchurch specialist diabetes complication screening clinic.

AIMS: To compare Maori and European utilisation of a specialist diabetes complication screening clinic. METHOD: All subjects attending the Christchurch specialist diabetes complication screening clinic over a 16 month period were asked to complete a questionnaire, which included data on age, ethnicity and diabetes treatment. The frequency of clinic attendance by age and ethnic group was then compared to the number of people in the general population, in the clinic catchment area. RESULTS: Of the 1356 subjects attending the complications screening clinic over the study period, 1347 completed the questionnaire. 1228 of the 1347 subjects (91.2%) were European and 84 (6.2%) were Maori. In the age range 45-64 years, Maori clinic attendance per 1000 general population was 25.6, compared to 7.57 per 1000 for Europeans. On a population basis, there were thus 3.4 times more Maori than Europeans attending the clinic. This figure is comparable with results from recent studies, which indicate that the prevalence of diabetes in this age range is about 3 to 5 times higher in Maori, compared to Europeans. CONCLUSIONS: Although this study failed to demonstrate evidence of inequality of health care utilisation, quantitative measures of utilisation are but one dimension of access to health care. Another dimension of health care access discussed in this paper, is the differing health care needs of different ethnic groups.

Adolescent↗
PubMed1993

Maori attitudes to diabetes and diabetes health care delivery in north Canterbury.

AIMS: The study aims were as follows: (1) To obtain information regarding Maori attitudes to diabetes and to the services provided by a specialist diabetes clinic in Christchurch; (2) to initiate discussion about local diabetes health care delivery for Maori. METHODS: A questionnaire was designed following advice from professional Maori health researchers, with the aim of assessing Maori attitudes to diabetes and specialist diabetes services, available in Christchurch. RESULTS: The questionnaire was delivered to 51 (77%) of the 66 Maori with noninsulin dependent diabetes (NIDDM), attending a specialist diabetes clinic in Christchurch. Although 47 of the 51 subjects were able to name one or more diabetes complications, only five subjects named heart disease as a complication, despite the fact that heart disease is a major cause of mortality in NIDDM: Subjects were selected on the basis of being hospital specialist clinic attenders and the majority were satisfied with currently available services, yet 10 of the 51 subjects indicated that they would prefer marae-based to hospital-based diabetes health care, if they had a choice. CONCLUSIONS: The process of questionnaire interview and dissemination of results proved to be a cost-effective means of initiating local discussion about future directions for Maori diabetes health care delivery.

Adult↗
PubMed1993

Use of insulin for 50 years or more in North Canterbury, New Zealand.

Previous reviews of diabetic subjects using insulin for 50 years or more have been based on clinic populations or on individuals receiving medals to mark this achievement. We interviewed all 11 subjects who had been on insulin for 50 years or more, identified from a population-based register of insulin users in North Canterbury, New Zealand. Seven of the 11 subjects had required treatment for micro- or macrovascular disease, but the functional level of the majority of survivors was nevertheless high. Diabetes had a major social impact on only one of the subjects interviewed.

Age Factors↗
PubMed1990

Clinical and ethnic characteristics associated with urinary albumin excretion in noninsulin dependent diabetic subjects attending the Wellington Hospital diabetes clinic.

In noninsulin dependent diabetes, elevation of urinary albumin excretion above the normal range is thought to predict increased mortality. A random urinary albumin/creatinine ratio and the following clinical characteristics were recorded on 405 patients with noninsulin dependent diabetes attending the Wellington Hospital diabetes clinic; (1) ethnic origin, (2) age, (3) sex, (4) age at diagnosis, (5) duration since diagnosis of diabetes, (6) body mass index, (7) systolic blood pressure, (8) diastolic blood pressure, (9) retinopathy, (10) insulin therapy, (11) antihypertensive therapy, and (12) the presence or absence of treated cardiovascular disease. The overall prevalence of elevated urinary albumin/creatinine ratio (greater than 2.2 mg/mmol) was 45%. Stepwise regression analysis showed that 12% of the variability of urinary albumin/creatinine ratio in our clinic population could be accounted for by ethnic origin of patients, with noncaucasians (the Maori, Pacific Islanders and Asians) having a higher urinary albumin excretion than caucasians (p less than 0.001). Systolic blood pressure, retinopathy and cardiovascular disease predicted a further 8% of this variability. The cause of this ethnic difference in urinary albumin excretion and its possible relationship to excess mortality in noncaucasians is not yet known.

Adolescent↗
PubMed1990

Comparison of urinary albumin excretion between Maoris, Pacific Island Polynesians and Europeans with non-insulin-dependent diabetes.

Elevated urinary albumin excretion is a marker for increased mortality and morbidity in European subjects with non-insulin-dependent diabetes. Urinary albumin excretion was compared in 32 Maoris, 34 Pacific Island Polynesians and 66 subjects of European origin with non-insulin-dependent diabetes attending a diabetes clinic in Wellington, New Zealand. The random urinary albumin to creatinine ratio was used as an estimation of urinary albumin excretion rate. The random urinary albumin to creatinine ratio was significantly higher in Maori and Pacific Island Polynesian subjects, compared to diabetic Europeans (geometric mean urinary albumin to creatinine ratios were 13.13, 12.00 and 2.79 mg/mmol respectively, P less than 0.05). These findings would be consistent with the high mortality and morbidity seen in the Maori and Pacific Island Polynesian diabetic populations. The correlation between hypertension and increased urinary albumin excretion was stronger in the Europeans than in the Maoris and Pacific Island Polynesians studied, suggesting that differences in blood pressure alone are unlikely to account for the observed differences in albumin excretion. Follow-up studies are required to determine whether diabetic Maoris and Pacific Island Polynesians with increased urinary albumin excretion have a similar prognosis to their European counterparts.

Albuminuria↗
PubMed1990

Overnight urinary growth hormone measurement in the diagnosis of acromegaly.

Several studies report higher urinary GH excretion in acromegalic patients compared to control subjects. We investigated the diagnostic potential of overnight urinary GH excretion in acromegaly, using a recently developed enzyme-linked immunosorbent assay. Overnight urine samples were obtained from 117 control subjects and nine patients with untreated acromegaly. GH excretion was higher in acromegalic patients compared to control subjects, with geometric mean total overnight values of 46.35 and 5.73 microU respectively. The range for total overnight urinary GH in control subjects was 0.75-21.75 microU and two of the nine patients with untreated acromegaly had GH measurements within this range. Urinary GH measurements were corrected using predictive clinical variables but this resulted in minimal improvement in discrimination between control subjects and acromegalic patients. Lack of complete discrimination between control subjects and acromegalic patients limits the usefulness of a single overnight urinary GH measurement as a screening test for acromegaly.

Acromegaly↗
PubMed1989

The Wessex Growth Study: first report.

The Wessex Growth Study is a community-based longitudinal survey of short children recruited from two Health Districts in Wessex during 1985-86 (cohort I) and 1986-87 (cohort II). Screening of new school entrants during 1985-86 identified only 1.3% who were at or below the 3rd centile for height as defined by Tanner and Whitehouse, suggesting a strong secular trend and an urgent need for updated height charts. After exclusion of the small number of children with underlying organic pathology and those from ethnic minorities, there were 84 children in cohort I on whom this report is based. These apparently normal, short children were sex- and age-matched with normal controls (10th-90th centile) from the same school class. Forty-two per cent of cohort I had a delayed bone age, and 34% lay above the 3rd centile after correction for parental height. Forty-four per cent were of low birth weight. The correlation between two successive height velocities measured at 6 and 12 months was only -0.14 for cohort I and -0.15 for their controls. Twelve-month mean height velocity SD scores (SDS) were -0.45 and +0.25, respectively, corresponding to the 33rd and 60th centiles, and rather higher than the 25th and 50th centiles expected in view of the heights of these children. Thirty-eight per cent of cohort I had a 12-month height velocity below the 25th centile, and in 16% height velocity was below the 10th centile. As a group, the children in cohort I grew more slowly than their controls, but the height velocity in 88% of cases lay within the control range.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Determination by Skeleton↗
PubMed1986

Cisplatin neuropathy with Lhermitte's sign.

Following chemotherapy with cis-diamminedichloroplatinum II (cisplatin) three patients developed Lhermitte's sign and peripheral neuropathy. The toxic side effects did not become apparent until after treatment had ceased. Because of increasing use of cisplatin to achieve lasting remission in patients with malignant disease proprioceptive and myelopathic side effects may become increasingly common.

Adult↗