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Biomedical subjects

H Lundborg

Publications and source records attributed to H Lundborg.

13 recordsLinked to original sources
PubMed1981

On the distribution and elimination of haloperidol in cholecystectomized patients.

A single oral dose of haloperidol was given to 19 patients prior to cholecystectomy. The concentration of haloperidol was assessed in serum, urine, fatty tissue, liver tissue, choledochal bile and bile bladder contents. The biological half-life of the drug in the serum was 25.1 +/- 12.9 hours, which is comparable to that in healthy volunteers. Only minute amounts of the drug were excreted with the urine. The drug concentration was only slightly elevated in choledochal bile but in the bile bladder contents it was about 11 times higher than that in the serum. The low concentration of haloperidol in the bile indicated that there was no substantial enterohepatic recirculation of the drug in this patient material. The concentration of haloperidol in fatty tissue was about 20 times, and in liver tissue 900 times higher than that in the serum. The corresponding figures for intramuscular administration of haloperidol were 10 and 325, respectively. A possible relationship between the side-effects and the route of administration is discussed.

Adipose Tissue↗
PubMed1980

Hippocampal glutamate release after porta cava anastomosis: reduced sensitivity to ammonia inhibition.

In vitro measurements of basal efflux and evoked release of exogenous and endogenous glutamate from rat hippocampus showed that exposition of the tissue to pathophysiological concentrations of ammonium chloride (3 mM) for 40--60 min abolished the KCl-induced release of endogenous glutamate. Basal efflux of endogenous glutamate was elevated by ammonium chloride with a delay of 30--40 min. In an attempt to link these observations to the pathogenesis of hepatic coma, rats were subjected to porta-cava anastomosis, and the hippocampal tissue was tested for ammonia sensitivity 3--4 weeks after the operation. The results showed that ammonia perfusion of the tissue was without effect effect on either basal or KCl-evoked release of endogenous glutamate. In addition, the utilization of glutamine for glutamate formation was influenced in hippocampal but not cortical tissue form porta-cava anastomized rats. The results suggest that ammonia is an important factor for the disturbed metabolism of the neurotransmitter pool of glutamate in hepatic failure.

Ammonia↗
PubMed1977

Effects of portacaval anastomosis on liver and brain protein synthesis in rats.

In vivo and in vitro protein synthesis was measured in livers from rats 3 weeks after a portacaval shunt (PCS) operation. A marked reduction in protein synthesis was observed, amounting to a 66 and 47% of inhibition, respectively. Above-saturation levels of amino acids were used in both conditions. The level of free exogenous amino acid was elevated consistently in the PCS animals 1 hour after isotope injection. In support of the data on liver protein synthesis, the incorporated radioactivity in serum proteins was reduced markedly. Heart muscle protein synthesis was unchanged while brain protein synthesis was inhibited when assayed in vivo. Neuronal cells showed a more marked inhibition of protein synthesis than did glial cells.

Amino Acids↗
PubMed1976

On the occurrence of lipoprotein-x in non-hemolytic jaundice.

In cholestasis, serum lipids are altered. The alterations could at least partially be ascribed to the occurrence of an abnormal lipoprotein, LP-X. In 103 patients with jaundice, out of whom 16 had extra-hepatic cholestasis, the presence of LP-X was tested and semi-quantificated (by visual grading) utilizing an immunological technique. In extra-hepatic cholestasis, all patients showed LP-X in serum, while in intra-hepatic drug-induced cholestasis 87% revealed this phenomenon. At the initial stage of acute hepatitis, in drug-induced cholestasis, and in extra-hepatic cholestasis, the semi-quantificated LP-X correlated with alkaline phosphatase values. In extra-hepatic cholestasis, LP-X disappeared soon after the obstruction was relieved by operation.

Bilirubin↗
PubMedDate not supplied

Methanol-soluble glycoproteins in human liver and brain.

After disc electrophoresis on 15% polyacrylamid gels of water-soluble and theta 50% methanol-soluble proteins from human liver or brain we have found two protein bands which have not been described in the literature before. These two protein fractions have been eluated from a Concanavaline A-Sepharose column. In this paper we present data showing that one of the two protein fractions is found in greater amounts in human liver than in human brain.

Brain Chemistry↗