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H Loosli

Publications and source records attributed to H Loosli.

17 recordsLinked to original sources
PubMed1984

Immunohistological study of malignant diffuse mesotheliomas of the pleura.

Paraffin sections from fifteen cases of malignant diffuse mesothelioma of the pleura and five cases of bronchial adenocarcinoma infiltrating the pleura were examined with an antiserum specific for factor VIII related antigen and with antisera against various epithelial markers: keratin, carcinoembryonic antigen (CEA), fat globule membrane antigen and secretory component. In all adenocarcinomas all the epithelial markers were present whereas the factor VIII related antigen was absent. The distribution of the fat globule membrane antigens, keratin, secretory component and factor VIII related antigen varied from one mesothelioma to another. The mesotheliomas were generally negative for CEA. The three mesotheliomas which were positive for CEA were also positive for alcian blue after hyaluronidase treatment. Amongst the markers used, CEA seems the most useful for the differential diagnosis between carcinoma and mesothelioma. However, the simultaneous detection of several markers allows the characterization of various phenotypes. Some of them are close to the phenotypes of true adenocarcinoma. A relation between a given phenotype and the biological behaviour of the tumour has still to be demonstrated.

Adenocarcinoma↗
PubMed1983

[Medullary cancer of the thyroid gland].

Thirty-one cases of medullary carcinoma of the thyroid have been studied over the past fifteen years at the University Hospital of the Canton of Vaud, Switzerland (CHUV). Twenty cases were of sporadic nature and eleven presented as part of the familial MEN II syndrome (multiple endocrine neoplasia), one of which showed the classical features of the rare MEN IIb type. It is important to distinguish between the familial and sporadic cases, because membership of the former group implies the investigation of associated endocrinopathies (pheochromocytoma, hyperparathyreoidism) and study of the family tree as the syndrome is autosomal dominant. Medullary carcinoma of the thyroid is a constant feature of the MEN II syndrome and is the cause of premature death in these patients. The familial type should be suspected if the carcinoma appears early in life, is located in the superior pole of the thyroid or is bilateral or multicentric, if the histology shows hyperplasia of the C cells and, of course, if there is a history of surgery for pheochromocytoma or hyperparathyroidism. Although total thyroidecomy is the rule for these familial cases, its role is debatable in sporadic medullary carcinoma of the thyroid. Postoperative follow-up of these patients is based on serum calcitonin determination, as this is an extremely sensitive marker. The ten year survival rate is 50%, with the worst prognosis in MEN IIb type.

Adenoma↗
PubMed1981

[Oral contraceptives and liver tumors].

That oral contraceptives have repercussions on the liver and bile ducts can no longer be denied. The role of oral contraceptives in inducing malignant or benign hepatic tumours is not universally admitted. From 1968 to 1979 the authors enumerated 29 hepatic tumours (18 benign, 11 malignant). In 13 cases the benign tumour was associated with the use of oral contraceptives and the tumour was diagnosed during or after the course of contraceptives. The signs and symptoms leading to the discovery of the benign hepatic tumour were an abdominal mass or enlarged liver in 3 cases and intraabdominal hemorrhage in one. In 9 cases the tumour was discovered at surgery. The contraceptive used was a preparation containing ethinyl-oestradiol, mestranol and a progesterone. The number of benign hepatic tumours has increased relatively in recent years, and this would seem to coincide with the utilization of oral contraceptives. For the moment definite proof is lacking, as the period during which the authors have studied this problem is still too short.

Contraceptives, Oral↗
PubMed1981

[Ischemic hepatitis. Clinico-pathological presentation of 2 cases].

Just before death, two female patients with congestive heart failure exhibited marked elevation of cytolytic hepatic enzymes, suggesting the diagnosis of viral hepatitis. Histologic examination of autopsy material led us to conclude in both cases on the presence of extensive and confluent ischemic centrizonal necrosis (shock liver). This picture probably reflected the consequences of liver perfusion failure. Ischemic hepatitis is the association of shock liver with marked elevation of transaminases.

Aged↗
PubMed1981

Normal rat liver cytochemistry: search for reactions adapted to the study of experimental cholestasis.

Experimentally induced intrahepatic cholestasis is characterized by a profound change in biliary secretion. Although there is general agreement that the biliary pole of the hepatocyte undergoes a singular alteration, it is know to which extent the microfilament network of the pericanalicular ectoplasm, the actual hepatocytic membrane at the biliary pole, and the intracanalicular glycocalix covering the membrane are implicated in this change. In order to establish whether ultrastructural cytochemistry is a suitable approach to a selective analysis of these three constituents, we decided to study the liver of normal rats with three different types of reactions (based on tannic acid, ruthenium hexamine, and digitonin, respectively). Moreover, we used different variants of each reaction and tried to determine which of them produced the most selective results; at the same time we kept in mind that these procedures are to be compatible with certain requirements of biological experimentation, like continuous bile flow measurement. Our findings show that, for a more detailed analysis of each of the above mentioned three cell constituents, these methods may provide more precise information.

Animals↗
PubMed1981

[Papillary mesothelioma of the left spermatic cord and tunica vaginalis].

The primary mesothelioma of the spermatic cord is a very rate tumor, histologically benign. Its evolution, because of the possibility of recurrence, is uncertain. We have found only six cases in the literature. Our observation relate the very quick apparition by a young Italian, 19 years old, of a left hydrocele under tension ascending into the inguinal fold. At operation, we discovered a mesothelioma in the spermatic cord and in the tunica vaginalis, covering both testicle and epididymis. Ten months after a left enlarged hemicastration, without scrotectomy, no recurrence has been reported.

Adult↗
PubMed1980

[Pleuro-pulmonary actinomycosis. Report of 4 cases].

Four cases of pulmonary actinomycosis are reported. Two cases (1978, 1979) were diagnosed on microscopic examination of lung parenchyma excised on suspicion of bronchogenic carcinoma. The third case was diagnosed retrospectively by reexamining the slides of a patient operated on in 1965, who presented with a similar history and chest X-ray. The fourth was diagnosed at autopsy in a patient who committed suicide. Actinomycosis is a rare disease which affects the lung in 15--20% of cases. Despite its name, actinomycosis is not due to a fungus but to an anaerobic gram-positive bacillus. The germ is a saprophyte of the human digestive tract and is very sensitive to penicillins. It may become pathogenic in a compromised host and usually produces cervico-facial lesions which develop by continuity from mouth mucosa. Abdominal or, more rarely, pulmonary lesions are due to ingestion or inhalation of infected material. Chest X-ray appearance of pulmonary actinomycosis mimics that of bronchogenic carcinoma. Actinomyces culture is difficult, and diagnosis is often based on microscopic examination of the surgical specimen only. Antibiotic therapy is a mandatory complement to surgical treatment.

Actinomyces↗
PubMed1979

[Blood flow disorders of the colon and rectum and their therapy].

Ischemic colitis or proctitis shows three evolutionary stages. a. complete recovery, b. fibrous stenosis, and c. acute ischemia leading to gangrene. The two first stages result more frequently from hemodynamic disorders than from vascular occlusions because, in the presence of the latter, collateral circulation develops. In addition, the colonic ischemia occurs in a septic medium in the presence of an abundant microbial flora which may be highly pathogenic.

Aged↗
PubMedDate not supplied

Ischemic diseases of the large intestine.

The blood flow within the walls of the digestive tract must be sufficient to maintain its structural and functional integrity. All episodes of vascular insufficiency cause ischemic damage to the organ and carry the threat of diffuse or focal necrosis. Certain forms of ischemic colitis or proctitis arise from episodes of reduced peripheric or splanchnic blood flow; indeed, those which do not culminate in necrosis of the colonic wall are more frequently caused by hemodynamic disorders than by vascular occlusions. The crisis is often mitigated by the development of collateral circulation; this is, however, of rather poor quality so patients become very vulnerable to subsequent slight changes in cardiac output. Necrotic, gangrenous ischemic colitis arises from a combination of occlusive damage to the arteries and general hemodynamic disturbances. The vascular insufficiency may be slight or severe, temporary or long-lasting, localized or diffuse. In addition, the attack occurs in a septic medium in the presence of abundant microbial flora which may be highly pathologic. Thus infection complicates and aggravates the ischemic damage, resulting in the gangrenous aspect of the lesion tending to hide its ischemic origin. Indeed, the variability of the manifestations of the disease in one of its primary characteristics, and is a function of the different causative factors. A knowledge of the anatomy and pathophysiology of the splanchnic circulation and its hemodynamics is essential for a full appreciation of the diagnosis and treatment of the disorders, and for the adoption of the aggressive approach necessary to improve the poor prognosis of ischemic diseases of the colon and rectum. All treatment should be based on 1) constant, prolonged intensive care; 2) precise monitoring of any change in status; 3) rapid excision of any necrotic (often gangrenous) tissue. Ischemic colitis is most likely to occur in elderly patients with a history of cardiovascular disease, but can also affect younger individuals. It is a frequent, potentially lethal, entity. Although it can be classified as a separate disease on the basis of its clinical, radiological and anatomical characteristics, it is often confused with other disorders of the colon. Although the abdominal surgeon is most likely to be concerned with this disease, the vascular surgeon incising the lower aorta should always be on the look-out for segmentary ischemia of the distal colon which may occur following operation.

Aged↗