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Biomedical subjects

H Loo

Publications and source records attributed to H Loo.

At least 91 records · Page 5Linked to original sources
PubMed1978

Thyroid autoantibody levels during lithium therapy.

The study of the levels of thyroid antibodies was conducted in 58 patients treated with lithium and in 40 subjects who received other psychotropic drugs and who were used as controls. The measure of the antithyroglobulin antibodies were made by passive hemagglutination and that of the antimicrosomal antibodies by indirect immunofluorescence. For the whole control group, the research of the antithyroglobulin antibodies was positive in 3 cases, i.e. 7.5%. For the 58 patients treated with lithium, this research was positive in 11 subjects, i.e. 19%: thus, lithium seems to cause immunological reactions in the thyroid. 5 lithium-treated patients developed a goiter. The antibody determination was positive in only 2 subjects and was negative in the others. The measure of antithyroid antibodies before lithium did not enable us to predict the emergence of thyroid complications. On the contrary, subjects treated with lithium presented signficantly high antibody levels without developing clinical thyroid manifestations.

Autoantibodies↗
PubMed1978

[Cannabis].

Cannabis produces a resin, the psychotropic effects of which are known since the High Antiquity. It induces euphoria, a feeling of pleasant dreaminess. Nevertheless, psychiatric disturbances such as psychomotor deficiency states or acute oniroïd states were described in heavy users countries. These psychiatric disorders put the accent on the starting or catalysing role of cannabis on the premorbid personality. The experimental studies of cannabis on the premorbid personality. The experimental studies of cannabis and its active substance (delta-g-tetrahydrocanabinol) bring information on this problem.

Animals↗
PubMed1975

[A French experience with methadone].

Methadone chlorhydrate has been administred to opiate addicts either for a short period with a decreasing dosage as a withdrawal cure, or for longterm treatments as a basis of a maintenance program. The analysis of precise clinical criteria regarding the socio-professional states, the family-life, the general health and the psychopathological diagnosis, allows an evaluation of the success of the cure and of its elective indications. The study of the personnality of the drug-addicts shows the importance of this factor in the potential success of a methadone cure. Urinary biological controls are regularly performed. This limitations and promises of this treatment discussed form a basis of a year's experience.

Administration, Oral↗
PubMed1975

[Pharmacoclinical value of the study of lithium cycles during 24 hours].

One cannot base a posology only upon morning lithiemy which turns out to be an unreliable criterion. It is useful to appreciate therapy equilibration through lithiemic cycle i.e. and every two hours dosage among patients on lithium carbonate or gluconate. Certain patients with quite an insufficient lithiemic morning level may be well equilibrated during day time. Lithiemy variations during the day are constantly reliable with the same patient. The study of nycthemeral variations among lithium salts treated patients allows us to understand some pathological subphenomena : intermittent tremor, subconfusional transitory onsets. Lastly lithiemic cycles allow comparison between lithiemy variations in manic or depressive relapses.

Carbonates↗
PubMed1975

[Trial of verification of the thymoanaleptic action of hypothalamic thyrostimulin (thyrotropin releasing factor of TRF) in melancholic states].

After the studies conducted by PRANGE and KASTIN in 1972, we tried to verify whether T.R.F. had a real thymo-analeptic effect and if a repeated administration could cure a depressive state. We used T.R.F. either intra-venously -- in slow perfusion or directly -- (1 mg per day) or p.o. (30 mg per day) on 18 mono or bipolar melancolic patients. The treatment lasted from 8 to 21 days. We have observed 4 good results obtained between the second and the sixth day, all among bipolar melancolic patients. In the other cases the results were negative. In all cases the tolerance was very good. These results, though very limited, present very interesting perspectives about a physiological substance whose site and actions are known with a relative precision.

Administration, Oral↗