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H Llewellyn

Publications and source records attributed to H Llewellyn.

7 recordsLinked to original sources
PubMed2000

Observer variation, dysplasia grading, and HPV typing: a review.

Squamous dysplasia of the cervix is a morphologic continuum that is divided into a number of categories. When the severity of a morphologic abnormality is assessed, whether in a biopsy sample or in an exfoliative smear, there can be significant observer variation. The statistical quantification of this variation, with particular reference to the kappa statistic and the influence of the number of categories utilized on the kappa statistic, is discussed. The contribution of information theory to the understanding of the reasons for observer variation is explored. The use of a binary (Bethesda) system of classification of squamous dysplasia and its validation by comparing consensus diagnoses with human papilloma virus type both in biopsy samples and in smears is reviewed.

Bacteriophage Typing↗
PubMedDate not supplied

Subcutaneous T-cell lymphoma presenting as panniculitis in children: report of two cases.

Two cases of peripheral T-cell lymphoma with primarily subcutaneous involvement and clinically presenting as panniculitis were reported in two children. One child developed florid hemophagocytic syndrome and was treated by combination chemotherapy but died 14 months later of disseminated fungal infection. The other child had mild systemic symptoms but no histological evidence of hemophagocytosis. Despite a more florid lymphomatous infiltrate, he attained a complete remission after a short course of prednisone and remains symptom-free at 3 years. Our report confirms that subcutaneous T-cell lymphoma is a distinct clinicopathological entity and highlights the two modes of clinical presentation. The development of florid hemophagocytic syndrome indicates a bad prognosis. This entity must be distinguished from other causes of panniculitis and immunophenotypic analysis of the atypical cells is essential in the diagnosis. Combination chemotherapy is the treatment of choice, but in patients who pursue an indolent course the administration of aggressive chemotherapy may be deferred.

Antineoplastic Combined Chemotherapy Protocols↗