Biomedical subjects
Publications and source records attributed to H Linker.
In Germany, nearly 8,000 patients are living with a functioning renal transplantation. The average age of those undergoing transplantation is 43.5 years. Without mismatch 70% of transplanted kidneys show normal function after five years. Other risk factors are important for the long term prognosis. The most important causes of death are cardiovascular diseases. The risk estimation factors are enumerated.
Being overweight is now accepted as one of the big health problems of our society. A major extent of overweight is associated with numerous disease and has to be considered as a disease itself. Considerable and intensive efforts are necessary to terminate the increasing trend or to turn it into the opposite direction. The OPTIFAST-program is an extensive therapy program with nearly guaranteed success. As compared to other programs, the longterm results are good, though they still need considerable improvement. A common strategy should be developed for a longterm and permanent program.
The insurance of one's life and one's capacity to work is only exceptionally possible for patients suffering from haematological diseases. Most of these diseases are still fatal after a predictable and thus a short period, in spite of certain therapeutical results. Exceptions such as the healing of, for instance, a lymphatic leucocythaemia are mentioned. It will be dealt with the approximate frequency of the disease, its characteristics and its prognosis.
About 50% of the circulating platelets can be taken from healthy donors by means of the cell separation technique. In order to investigate the effect of cell separation on thrombopoesis bone marrow samples were taken from 12 voluntary donors up to 5 times. The megacaryocytes were analyzed before and after cell separation by morphometric measures and determinations of platelet count and platelet function (adhesion, aggregation, spreading, retraction) were carried out. Removing of large amounts of platelets form the circulation by stimulation of thrombopoesis resulted in an increase of the peripherical platelet count already 48 h after cell separation. Of the platelet functions tested only aggregation induced by collagen was found to be increased after cell separation as compared to that before the procedure.
In two siblings, brother and sister, with a history of bleeding Bernard-Soulier syndrome was diagnosed: The stronger affected sister showed a high percentage of giant blood platelets, an abnormal platelet spreading test and a defect in ristocetin and bovine fibrinogen-induced platelet aggregation. In addition, the content of platelet ATP, ADP and AMP was increased. As leucocyte counts were consistently decreased in the more seriously affected anaemic sister, repeated cytochemical examinations of the haemopoietic cells were carried out, revealing maturational defects in the whole haemopoietic system. Therapy with tranexamic acid reduced bleeding in the sister and she has not been anaemic since.
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In cells of an acute, predominantly promyelocytic differentiated leukemia ring-shaped inclusions could be demonstrated by light- and electron-microscopic examinations. The patient showed good response to aggressive chemotherapy with complete remission. It is discussed, how far the presence of these morphological characteristics will have any bearing on the classification of this variety of leukemia.
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