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Biomedical subjects

H Lindberg

Publications and source records attributed to H Lindberg.

106 records · Page 6Linked to original sources

The relation between labor and coxarthrosis.

Three hundred thirty-two laborers in a shipyard, all of whom had been working for decades in heavy industry, were compared with regard to the occurrence of coxarthrosis with a similar sized group of white-collar workers and with a random population sample. All three sets of men were of the same age. About one-fourth (the same in all three groups) had been referred for a hip roentgenographic examination at some time over the previous decades. In the group of laborers and their white-collar controls, coxarthrosis occurred in about 3%, with no difference between the two samples. The occurrence was less, but not significantly less, in those men who had been randomly selected from the population.

Aged↗

Changes in bone mineral content in the femur following total hip arthroplasty.

Bone mineral content (BMC) in the distal end of the femoral shaft was monitored with single-photon gamma-absorptiometry for 72 weeks after surgery in 46 patients with coxarthrosis treated by total hip arthroplasty (THA). After an initial increase, which was greater in men than in women, BMC decreased during the first postoperative year to approximately the initial value in men, whereas in women the final outcome was a 10% net loss. No influence of the type of operation or of the preoperative or postoperative capacity of the patients could be demonstrated. The loss of bone mineral was surprisingly low compared with that noted after other injuries of similar or even less magnitude.

Aged↗

Ibuprofen and compression bandage in the treatment of ankle sprains.

One hundred patients with sprained ankles were randomly allocated to treatment with Ibuprofen 800 mg X 3 daily and placebo and to treatment with two qualities of compression bandaging. Neither Ibuprofen nor high quality bandaging had a significant effect on the swelling, pain or tenderness.

Adult↗

Haemodynamic changes with the administration of nitrous oxide during coronary artery surgery.

Haemodynamic responses to 50% nitrous oxide in oxygen during coronary artery surgery were investigated in 10 patients. Morphine, diazepam and pancuronium were given intravenously as both induction and maintenance anaesthesia. A significant decrease was seen in heart rate, arterial pressure, pulmonary artery pressure, heart rate-systolic arterial pressure product, peripheral vascular resistance, left ventricular end-diastolic pressure, dP/dT of the left ventricle and resistance as measured in the graft to the left anterior descending coronary artery (LAD). No variations occurred in cardiac output, stroke volume, flow in the LAD-graft, pulmonary artery pressure or heart rate-systolic pulmonary artery pressure product or in dP/dT of the right ventricle. Pulmonary vascular resistance increased. It was concluded that left ventricular performance did not decrease and that no deterioration of the oxygenation to the myocardium seemed to occur.

Adult↗

Surgical treatment of aneurysms of the aortic arch.

A new approach to the challenge of surgical treatment of aneurysms of the aortic arch is described. Former techniques have been dependent on separate cannulation of the cerebral arteries, but induction of deep total body hypothermia to 15 degrees C and circulatory arrest is considered to give sufficient time for resection of the aneurysms and completion of the anastomoses. This is made possible by excising the aneurysms in such a way that the orifices of the three arch vessels are trimmed to leave a small cuff of tissue around the vessels, thereby reducing the number of anastomoses to three. The successful treatment of three patients with this method, is reported.

Adult↗

Umbilical vein grafts and PTFE grafts for femoro-popliteal bypass. Preliminary results.

This retrospective, multiple-center study includes 172 PTFE (Gore-Tex) and 35 umbilical vein grafts (Bio-graft) used for femoro-popliteal bypass grafting. The one-year patency rate was approximately 63% in both groups. Until further experience is accumulated, autogenous saphenous vein should probably be the first choice for femoro-popliteal bypass grafting. Prosthetic grafts should preferably be used when the saphenous vein is absent or insufficient.

Aged↗

The increase of body iron stores estimated by the increase of serum ferritin concentration during ferrous sulphate treatment after gastrointestinal surgery.

A 6-wk period of iron therapy with ferrous sulphate (80 mg Fe++ three times daily) was given to 16 males and 16 females on whom previously various common gastrointestinal surgery had been performed and who had empty iron stores estimated from low serum ferritin concentration. The results were compared with a control group corresponding to the study group in respect to sex, number of patients, primary disease, previous operation, and the empty iron stores. The iron therapy replenished the empty body iron stores, because the serum ferritin concentrations increased from 11 +/- 7 to 35 +/ 13 micrograms/liter (p less than 0.001) in the males and from 9 +/- 6 to 30 +/- 10 micrograms/liter (p less than 0.001) in the females, whereas the corresponding changes in the control group were from 10 +/- 9 to 11 +/- 8 micrograms/liter and from 11 +/- 8 to 13 +/- 11 micrograms/liter in the males and females, respectively. Also the blood hemoglobin concentration increased in the group receiving iron from 136 +/- 11 to 150 +/- 11 g/liter (p less than 0.01) and from 130 +/- 12 to 142 +/- 11 g/liter (p less than 0.01) and the serum iron from 14 +/- 6 to 18 +/- 5 mmol/liter (p less than 0.01) and from 13 +/- 6 to 17 +/- 6 mmol/liter (p less than 0.01) in males and females, respectively, whereas corresponding changes in the control group for hemoglobin were from 135 +/- 10 to 137 +/- 11 g/liter and from 129 +/- 11 to 131 +/- 10 g/liter and for serum iron from 14 +/- 6 to 14 +/- 5 mmol/liter and from 14 +/- 6 to 14 +/- 5 mmol/liter, in the males and females, respectively. The response to iron treatment varied considerably between different patients, because in some few patients serum ferritin decreased during the study and in some the increase was several-fold the initial value. The study shows that ferrous sulphate treatment is an effective and practical way to replenish the empty iron stores, estimated from serum ferritin concentrations, in patients after various gastrointestinal surgery and that concomitantly the blood hemoglobin and serum iron concentrations will increase.

Adult↗

The prevalence of gonarthrosis and its relation to meniscectomy in former soccer players.

The prevalence of radiographic signs of gonarthrosis and its relation to knee injuries were studied in 286 former soccer players--215 nonelite and 71 elite players--and were compared with 572 age-matched controls with a mean age of 55 years. The prevalence of gonarthrosis among the nonelite players was 4.2%, among the elite players 15.5%, and among the controls 1.6%. Seven of the soccer players had known anterior cruciate ligament injuries, and 40 had had meniscectomies. Of the 32 nonelite players with knee injuries, 4 (13%) had gonarthrosis, and of the 183 without known knee injuries 5 (3%) had gonarthrosis. Among the elite players, the prevalence of gonarthrosis in knees without diagnosed injuries was 11%. We conclude that soccer, especially at an advanced level, is associated with an increased risk for gonarthrosis. After excluding subjects with known knee injuries, there was no difference between nonelite players and controls, but we found a higher rate of gonarthrosis among the elite players.

Adult↗

High serum lactic acid concentration after laparotomy and peritonitis in iron stores depletion. An experimental study on the rat.

Total depletion of iron stores with a moderately decreased blood hemoglobin concentration (114 x 10 vs. 155 x 12 g/l in controls, n = 28) was produced in rats (n = 28) by rearing them for six weeks on an iron free diet, in iron free cages, starting at two weeks of age. The controls were treated at the same time in same conditions, except that they were given a normal supply of dietary iron. In all rats laparotomy and peritonitis by ligation and puncture of the caecum were carried out with ether anesthesia. Postoperative mortality and blood lactic acid concentration were followed for 120 minutes after the procedure. Postoperative mortality (8 of 28, 29% vs. 1 of 28, 4%) and blood lactic acid concentration (3.3 x 0.3 to 3.6 x 0.5 vs. 1.4 x 0.1 to 1.8 x 0.2 mmol/l) were higher (p less than 0.001) in the experimental group than in the control animals. The surviving rats (2.0 x 0.1 to 2.1 x 0.2 mmol/l) had a lower (p less than 0.001) blood lactic acid concentration than those who died (5.6 x 0.5 to 6.1 x 1.1). The results suggest that total lack of iron producing a moderate decrease of blood hemoglobin concentration creates a significant risk in abdominal surgery and focus the activation of the anaerobic energy yielding process.

Animals↗

Intra-aortic balloon pumping support in surgically treated valvular heart disease: prognostic factors and survival.

Prognostic factors of Low Output Syndrome (LOS) requiring operative circulatory support by intra-aortic balloon-pumping (IABP) counterpulsation, were analysed in a population of 841 patients who underwent heart valve replacement surgery between June 1977 and May 1985. The incidence of IABP circulatory support was 6.8%. Mean survival time of patients who needed IABP was 2.35 years +/- 0.425 vs 6.30 years +/- 0.103 for patients who didn't have this complication. A multivariate analysis using the logistic model was done to pinpoint factors predictive of IABP support. The prognostic factors were pre-operative functional class, presence of prior valve replacement, presence of concomitant surgery and presence of endocarditic etiology. The subgroup of 58 patients undergoing balloon counterpulsation was analysed for factors predictive of survival using a multivariate analysis of the Cox' model. Presence of aortic or mitral regurgitation was found to be the independent risk factor of mortality. Using a combination of prognostic factors, we pinpointed groups of patients at high risk of needing post-operative balloon pump counterpulsation support. The necessity of an alternative procedure for the mechanical support of the failing circulation is underlined.

Aortic Valve↗

The coronary prone.

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Adult↗